NEWS
Cancer Cell Proliferation is Inhibited by Specific Modulation Frequencies
02/12/2011

Cancer Cell Proliferation is Inhibited by Specific Modulation Frequencies

Jacquelyn W. Zimmerman, Michael J. Pennison, Ivan Brezovich, Nengjun Yi, Celeste T. Yang, Ryne Ramaker, Devin Absher, Richard M. Myers, Niels Kuster, Frederico P. Costa, Alexandre Barbault, and Boris Pasche, British Journal of Cancer, Volume 106, Issue 2, pp. 307–313, January 17, 2012.  Online  December 1, 2011


This paper complements the clinical evidence that low amplitude-modulated electromagnetic fields may elicit therapeutic responses in patients with cancer. Hepatocellular carcinoma (HCC) cells were exposed to the same signals used in in vitro exposure systems designed to replicate in vivo conditions. The modulation frequencies were previously identified by biofeedback methods in patients with a diagnosis of cancer. The control exposure consisted of randomly chosen modulation frequencies within the same 100 Hz–21 kHz range as cancer-specific frequencies. The growth of HCC and breast cancer cells was significantly decreased by HCC-specific and breast cancer-specific modulation frequencies, respectively. However, the same frequencies did not affect proliferation of nonmalignant hepatocytes or breast epithelial cells. Inhibition of HCC cell proliferation was associated with down-regulation of XCL2 and PLP2. The IT'IS Foundation designed and provided the exposure system.

The significances of the paper:

  • Specific cells responded to a weak 27-MHz signal that was AM-modulated with specific frequencies
  • The same cells did not show any response if exposed to the same carrier but with different modulation frequencies
  • If the effect can be independently replicated, this constitutes a major breakthrough in the field of bioelectromagnetics.

 

PUBLICATIONS

21/11/2011

Contact
nk@itis.ethz.ch

 

Local Tissue Temperature Increase of a Generic Implant Compared to the Basic Restrictions Defined in Safety Guidelines

Adamos Kyriakou, Andreas Christ, Esra Neufeld, and Niels Kuster, Bioelectromagnetics, Volume 33, Issue 5, pp. 366–374, July 2012, online November 21

 
PUBLICATIONS

21/10/2011

Contact
douglas@itis.ethz.ch

 

Influence of the Hand on the Specific Absorption Rate in the Head

Chung-Huan Li, Mark Douglas, Erdem Ofli, Benoit Derat, Sami Gabriel, Nicolas Chavannes, and Niels Kuster, IEEE Transactions on Antennas and Propagation, Volume 60, Issue 2, pp. 1066–1074, February 2012, online October 21, 2011

 
PUBLICATIONS

22/09/2011

Contact
murbach@itis.ethz.ch

 

Local SAR Enhancements in Anatomically Correct Children and Adult Models as a Function of Position within 1.5T MR Body Coil

Manuel Murbach, Eugenia Cabot, Esra Neufeld, Marie-Christine Gosselin, Andreas Christ, Klaas Prüssmann, and Niels Kuster, Progress in Biophysics and Molecular Biology, Volume 107, Issue 3, pp. 428–433, December, 2011. Online September 22

 
PUBLICATIONS

31/08/2011

Contact
douglas@itis.ethz.ch

 

Application of an Induced Field Sensor for Assessment of Electromagnetic Exposure from Compact Fluorescent Lamps

Jagadish Nadakuduti, Mark Douglas, Myles Capstick, Sven Kühn, and Niels Kuster, Bioelectromagnetics, Volume 33, Issue 2, pp. 166–175, February 2012. Online August 31, 2011

 
PUBLICATIONS

15/08/2011

Contact
nk@itis.ethz.ch

 

Mechano-Chemical Simulation of a Solid Tumor Dynamics for Therapy Outcome Predictions

Sven Hirsch, Dominik Szczerba, Bryn Lloyd, Michael Bajka, Niels Kuster, and Gabor Szekely, International Journal for Multiscale Computational Engineering, Volume 9, Issue 2, pp. 231–241, 2011, online August 15

 
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