NEWS
17/07/2017
PUBLICATIONS

Effects of body habitus on internal radiation dose calculations using the 5-year-old anthropomorphic male models

Tianwu Xie, Niels Kuster, and Habib Zaidi, Physics in Medicine & Biology, Volume 62, Issue 15, pp. 6185–6206, online 13 July 2017, doi: 10.1088/1361-6560/aa75b4

Computational phantoms are commonly used in internal radiation dosimetry to assess the amount and distribution pattern of energy deposited in various parts of the human body from different internal radiation sources. Radiation dose assessments are commonly performed on predetermined reference computational phantoms, although the argument for individualized patient-specific radiation dosimetry exists. The aim of this study is to evaluate the influence of body habitus on internal dosimetry and to quantify the uncertainties in dose estimation correlated with the use of fixed reference models. The 5-year-old IT'IS male phantom was modified to match target anthropometric parameters, including body weight, body height, and sitting/height stature ratio (SSR) determined from reference databases, thus enabling the creation of 125 5-year-old habitus-dependent male phantoms with 10th, 25th, 50th, 75th, and 90th percentile body morphometries. We evaluated the absorbed fractions and the mean absorbed dose to the target region per unit cumulative activity in the source region (S-values) of F-18 in 46 source regions for the 125 anthropomorphic 5-year-old hybrid male phantoms generated by means of the Monte Carlo N-Particle eXtended (MCNPX) general purpose Monte Carlo transport code and calculated the absorbed dose and effective dose of five 18F-labelled radiotracers for children of various habitus. For most organs, the S-value of F-18 presents stronger statistical correlations with body weight, standing height, and sitting height than with BMI and SSR. The self-absorbed fraction and self-absorbed S-values of F-18 and the absorbed dose and effective dose of 18F-labelled radiotracers present with the strongest statistical correlations with body weight. For 18F-amino acids, 18F-brain receptor substances, 18F-FDG, 18F-L-DOPA, and 18F-FBPA, the mean absolute effective dose differences between phantoms of different habitus and fixed reference models are 11.4%, 11.3, 10.8, 13.3, and 11.4%, respectively. Total body weight, standing height, and sitting height have considerable effects on human internal dosimetry. Radiation dose calculations for individual subjects based on the most closely matched habitus-dependent computational phantom should be considered as an alternative to improve the accuracy of the estimates.

The scientific and technical impact of the study can be summarized as:

  • The detailed analysis of habitus-dependent dosimetric results for the 5-year-old child supports arguments for the application of individual patient dose assessment.
  • Total body weight, standing height, sitting height, BMI, and SSR influence the calculation of absorbed fractions and S-values of F-18 and absorbed dose and effective dose of 18F-labelled radiotracers.
  • For most organs, the absorbed fractions of F-18 increase as a function of total body weight and BMI, while the self-absorbed S-values of F-18 as well as absorbed and effective doses of 18F-labelled radiotracers decrease with body weight and BMI.
  • Dose comparisons between habitus-dependent phantoms and predefined phantoms corresponding to ICRP reference data reveal that the use of the most closely matched habitus-dependent phantom is superior to the use of a predefined reference phantom for estimation of internal dose in an individual patient. 
Other News

06/07/2017

Contact
nk@itis.ethz.ch

 

IT'IS and ZMT at Auden Group Seminar in Taipei, Taiwan July 6, 2017

Niels Kuster and Erdem Ofli were presenters at the Auden Group Seminar on the integration of next-generation electromagnetic technologies in biomedical applications held in Taipei, Taiwan July 6, 2017.

 
AWARDS

09/06/2017

Contact
murbach@itis.ethz.ch

 

Manuel Murbach Wins Arthur Pilla Young Scientist Award at BioEM2017

Manuel Murbach was recently named the Arthur Pilla Young Scientist at BioEM2017, the joint annual meeting of BEMS and EBEA, in Hangzhou, China June 5 – 9, 2017, for his platform presentation entitled "MRI radiofrequency exposure estimation in morphed patient anatomies".

 
PUBLICATIONS

01/06/2017

Contact
nk@itis.ethz.ch

 

Noninvasive Deep Brain Stimulation via Temporally Interfering Electric Fields

Nir Grossman, David Bono, Nina Dedic, Suhasa B. Kodandaramaiah, Andrii Rudenko, Ho-Jun Suk, Antonino M. Cassara, Esra Neufeld, Niels Kuster, Li-Huei Tsai, Alvaro Pascual-Leone, and Edward S. Boyden, Cell, Volume 169, Issue 6, pp. 1029–1041, online 1 June 2017, doi: 10.1016/j.cell.2017.05.024

 
Other News

02/05/2017

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nk@itis.ethz.ch

 

Swiss Chamber of Technical and Forensic Experts Visit Zurich43

Members of the Swiss Chamber of Technical and Forensic Experts visited the IT'IS Foundation to learn about procedures for safety certification of wireless devices.

 
Other News

28/04/2017

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nk@itis.ethz.ch

 

ETH Zurich D-ITET Masters Students and VetClinics-UZH Faculty Visit Zurich43

Master students from the Department of Information Technology and Electrical Engineering (D-ITET) of the ETH Zurich visited Zurich43 for a seminar on "Non-ionising radiation: a health risk from low doses?". The visit was part of the course "Energy, Resources, Environment: Risks and Prospects" taught by Dr. Thomas Flüeler. The students toured the IT’IS research facilities, with stops at the Yellow Chamber, ICEy and TDS probes, and the AllyPally phantoms. The seminar continued with presentations from representatives of the VetSuisse faculty and Ärztinnen und Ärzte für Umweltschutz and concluded with time for questions and discussion.

 
AWARDS

26/04/2017

Contact
nk@itis.ethz.ch

 

IT’IS Wins Award for Best Abstract in Session at the 2017 Annual Meeting of the International Society for Magnetic Resonance in Medicine

Manuel Murbach of the IT'IS Foundation won the best abstract award in a joint session on High Field Systems & Applications & MR Safety at the 25th Annual Meeting & Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM) in Honolulu, Hawaii, 22 – 27 April 2017 for his presentation entitled "Morphing and Posing of Computational Anatomical Models: Enhanced Patient-Specific MRI RF Exposure Prediction."

 
PRESS

20/04/2017

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nk@itis.ethz.ch

 

Sven Kühn cited in article about in-ground base station antennas by the Swiss newspaper “Tagesanzeiger”

Sven Kühn cited in article about in-ground base station antennas by the Swiss newspaper "Tagesanzeiger".

 
Other News

12/04/2017

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nk@itis.ethz.ch

 

Two IT'IS Papers Supporting NIEHS NTP Study of Cell Phone RF Radiation and Carcinogensis in Rats Published Online

Two papers in support of the preliminary findings of the US National Toxicology Program (NTP) Study on Cell Phone Radiofrequency Radiation (RFR) and Carcinogensis have recently been published online in IEEE Transactions on Electromagnetic Compatibility.

 
PUBLICATIONS

05/04/2017

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nk@itis.ethz.ch

 

Life-Time Dosimetric Assessment for Mice and Rats Exposed in Reverberation Chambers for the Two-Year NTP Cancer Bioassay Study on Cell Phone Radiation

Yijian Gong, Myles H. Capstick, Sven Kuehn, Perry F. Wilson, John M. Ladbury, Galen Koepke, David L. McCormick, Ronald L. Melnick, and Niels Kuster, IEEE Transactions on Electromagnetic Compatibility, online 17 March 2017, doi: 10.1109/TEMC.2017.2665039

 
PUBLICATIONS

04/04/2017

Contact
nk@itis.ethz.ch

 

A Radio Frequency Radiation Exposure System for Rodents Based on Reverberation Chambers

Myles H. Capstick, Sven Kuehn, Veronica Berdinas-Torres, Yijian Gong, Perry F. Wilson, John M. Ladbury, Galen Koepke, David L. McCormick, James Gauger, Ronald L. Melnick, and Niels Kuster, IEEE Transactions on Electromagnetic Compatibility, Volume 59, Issue 4, pp. 1041–1052. August 2017, online 17 March 2017, doi: 10.1109/TEMC.2017.2649885

 
PUBLICATIONS

28/03/2017

Contact
nk@itis.ethz.ch

 

Computational hybrid anthropometric paediatric phantom library for internal radiation dosimetry

Tianwu Xie, Niels Kuster, and Habib Zaidi, Physics in Medicine and Biology, Volume 62, Issue 8, pp. 3263–3283. 21 April, 2017, online 28 March 2017, doi: 10.1088/1361-6560/aa63d0

 
PUBLICATIONS

13/03/2017

Contact
nk@itis.ethz.ch

 

ELF‑MF exposure affects the robustness of epigenetic programming during granulopoiesis

Melissa Manser, Mohamad R. Abdul Sater, Christoph D. Schmid, Faiza Noreen, Manuel Murbach, Niels Kuster, David Schuermann, and Primo Schär, Scientific Reports 2017, Volume 7, Article number: 43345, online: 07 March 2017, DOI: 10.1038/srep43345. 

 
Other News

23/02/2017

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nk@itis.ethz.ch

 

Faculty and Masters Students from the University of Kassel Visit Zurich43

Faculty and masters students from the University of Kassel Electrical Communication Engineering (ECE) degree program visited Zurich43 on Tuesday, February 21, 2017 for an introduction to IT'IS research programs and a tour of the laboratories.

 
PUBLICATIONS

03/02/2017

Contact
nk@itis.ethz.ch

 

Evaluation of the potential of mobile phone specific electromagnetic fields (UMTS) to produce micronuclei in human glioblastoma cell lines

Halh Al-Serori, Michael Kundi, Franziska Ferk, Miroslav Mišík, Armen Nersesyan, Manuel Murbach, Tamara T. Lah, and Siegfried Knasmüller, Toxicology In Vitro, Volume 40, pp. 264–271, April 2017, online 24 January 2017, DOI: 10.1016/j.tiv.2017.01.012.

 
PUBLICATIONS

02/02/2017

Contact
nk@itis.ethz.ch

 

Effects of personalised exposure on self-rated electromagnetic hypersensitivity and sensibility – A double-blind randomised controlled trial

 

Imke van Moorselaar, Pauline Slottje, Pia Heller, Rob van Strien, Hans Kromhout, Manuel Murbach, Niels Kuster, Roel Vermeulen, and Anke Huss, Environment International, Volume 99, pp. 255–262, February 2017, online 09 December 2016, doi: 10.1016/j.envint.2016.11.031.

 
Other News

01/02/2017

Contact
nk@itis.etzh.ch

 

Zurich43 Retreat 2017 at Pilatus Kulm - Communication

Twenty-five Zurich43 associates and three IT'IS Foundation board members gathered in the historic Hotel Pilatus-Kulm high above Luzern 30 – 31 January 2016 for their annual retreat, this year on communication. The goal of the two-day retreat was to find ways to improve communication skills across various target groups, channels, and markets, both within Z43 and with the outside world.

 
Other News

24/01/2017

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nk@itis.etzh.ch

 

X-TRA, X-TRA! Inaugural Zurich43 Party: X-TRAordinary Nine = X-TRAordinary Fun!

The 2017 Z43 annual party held at Zurich’s X-TRA concert hall celebrated the emerging corporate identity and global reach of the Z43 brand.

 
VIRTUAL POPULATION

20/01/2017

 

Successful NEUROMAN Project Start and Kickoff Meeting

Partners form Switzerland and Korea join forces to create first ever computational phantom with detailed neuronal networks.

 
PUBLICATIONS

15/01/2017

Contact
nk@itis.ethz.ch

 

Terahertz reflectarrays and nonuniform metasurfaces

Daniel Headland, Tiaoming Niu, Eduardo Carrasco, Derek Abbott, Shruti Nirantar, Sharath Sriram, Madhu Bhaskaran, Christophe Fumeaux, and Withawat Withayachumnankul, IEEE J. Sel. Topics Quantum Electron., online 20 December 2016, DOI: 10.1109/JSTQE.2016.2640452

 
Other News

31/12/2016

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nk@itis.etzh.ch

 

Important Milestone in Cancer Therapy

As of January 2017, the Swiss Federal Office of Public Health (FOPH) will include hyperthermia treatment in combination with radiation therapy as covered therapy in the Swiss basic health insurance catalog.

 
Other News

18/12/2016

 

3D Atlas of Human Embryology

A team from the Academic Medical Center (AMC) in Amsterdam NL has published a comprehensive 3D Atlas of Human Embryology. The atlas is made freely available to the scientific community to facilitate embryology education and research.

 
Other News

25/11/2016

 

A Brain–Spine Interface Alleviating Gait Deficits after Spinal Cord Injury in Primates

Marco Capogrosso, Tomislav Milekovic, David Borton, Fabien Wagner, Eduardo Martin Moraud, Jean-Baptiste Mignardot, Nicolas Buse, Jerome Gandar, Quentin Barraud, David Xing, Elodie Rey, Simone Duis, Yang Jianzhong, Wai Kin D. Ko, Qin Li, Peter Detemple, Tim Denison, Silvestro Micera, Erwan Bezard, Jocelyne Bloch, and Grégoire Courtine, in Nature, Volume 539, Issue 7628, pp. 284 – 288, 9 November 2016

 
Other News

22/11/2016

 

Noninvasive Deep Brain Stimulation via Delivery of Temporally Interfering Electric Fields

Nir Grossman, David Bono, Suhasa Kodandaramaiah, Andrii Rudenko, Antonino Cassara, Esra Neufeld, Sheeba A. Anteraper, Atsushi Takahashi, Niels Kuster, Li-Huei Tsai, Alvaro Pascual-Leone, and Edward S. Boyden at the 46th annual meeting of the Society for Neuroscience, San Diego, CA, USA, November 12 – 16, 2016

 
Other News

14/11/2016

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nk@itis.etzh.ch

 

National Future Day 2016 – Gamma-Detector

On Thursday  November 10, six enthusiastic 11 – 13 year olds visited Z43 for Swiss National Future Day 2016, where they each manfactured a working gamma detector.

 
PUBLICATIONS

31/10/2016

Contact
nk@itis.ethz.ch

 

From Image-Based Modeling to the Modeling of Imaging with the Virtual Population

Esra Neufeld, Bryn Lloyd, and Niels Kuster, in Simulation and Synthesis in Medical Imaging, Proceedings of the First International Workshop, SASHIMI 2016, Held in Conjunction with MICCAI 2016, Athens, Greece, October 21, 2016, Volume 9968 of the series Lecture Notes in Computer Science, pp. 45–54, online October, 2016

 
PUBLICATIONS

14/10/2016

Contact
nk@itis.ethz.ch

 

Signaling by sulfur-containing molecules. Quantitative aspects.

Willem H. Koppenol and Patricia L. Bounds, Archives of Biochemistry and Biophysics, online September 23, 2016

 
PUBLICATIONS

12/10/2016

Contact
nk@itis.ethz.ch

 

Magnetic Nanoparticle-Induced Hyperthermia with Appropriate Payloads: Paul Ehrlich’s “Magic (Nano)bullet” for Cancer Theranostics?

Nilroy R. Datta, Sunil Krishnan, Daniel E. Speiser, Esra Neufeld, Niels Kuster, Stefan Bodis, and Heinrich Hofmann,
Cancer Treatment Reviews, Volume 50, pp. 217–227, online September 2016

 
PUBLICATIONS

10/10/2016

Contact
nk@itis.ethz.ch

 

Approach to Validate Simulation-Based Distribution Predictions Combining the Gamma-Method and Uncertainty Assessment: Application to Focused Ultrasound

Esra Neufeld, Adamos Kyriacou, Wolfgang Kainz, and Niels Kuster, Journal of Verification, Validation and Uncertainty Quantification, Volume 1, Issue 3, 031006, online September 2016

 
PRESS

23/09/2016

Contact
nk@itis.ethz.ch

 

 
PUBLICATIONS

23/09/2016

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nk@itis.ethz.ch

 

Virtual Population-Based Assessment of the Impact of 3 Tesla Radiofrequency Shimming and Thermoregulation on Safety and B1+ Uniformity

Manuel Murbach, Esra Neufeld, Eugenia Cabot, Earl Zastrow, Juan Córcoles, Wolfgang Kainz, and Niels Kuster, Magnetic Resonance in Medicine, Volume 76, Issue 3, pp. 986–997, September 2016; Early View, September 2015, online September 24, 2015

 
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