NEWS
03/02/2017
PUBLICATIONS

Evaluation of the potential of mobile phone specific electromagnetic fields (UMTS) to produce micronuclei in human glioblastoma cell lines

Halh Al-Serori, Michael Kundi, Franziska Ferk, Miroslav Mišík, Armen Nersesyan, Manuel Murbach, Tamara T. Lah, and Siegfried Knasmüller. Toxicology In Vitro, Volume 40, pp. 264–271, April 2017, online 24 January 2017, DOI: 10.1016/j.tiv.

Recent epidemiological studies indicate that exposure to mobile-phone-specific electromagnetic fields (EMF) causes development of glioblastomas in humans. In this study, the effects of the universal mobile telecommunications system radiofrequency (UMTS-RF) signal – also known as 3G – on the formation of micronuclei (MN) due to structural and numerical chromosomal aberrations and other anomalies, such as nuclear buds (NB) that reflect gene amplification were assessed. Human glioblastoma cell lines, which were cultivated for 16 h in the presence and absence of fetal calf serum, were exposed to EMF with the well-characterized sXc1950 exposure system designed by the IT’IS Foundation. No evidence for induction of MN or other anomalies was found when the cells were exposed to EMF at specific absorption rate (SAR) levels of 0.25, 0.50, and 1.00 W/kg, which suggests that the UMTS-RF signal does not cause chromosomal damage in glioblastoma cells. However, at the highest exposure dose of 1.00 W/kg, morphological features observed in U251 cells indicate the induction of programmed cell death (apoptosis). The mechanisms that may lead to apoptosis induction will be investigated in follow-up studies.

The scientific and technical impact of the study can be summarized as:

    • The double-blinded exposure protocols of the sXc1950 system were used in RF exposure experiments on human glioblastoma cells to investigate possible RF mobile-phone-specific radiation effects on chromosomal stability.
    • No evidence was found for induction of MN formation or several other nuclear anomalies.
    • Induction of apoptosis was observed in a p53-mutated cell line (U251), while, in p53-proficient cells (U87), the apoptosis rate was not increased.
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PUBLICATIONS

02/02/2017

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nk@itis.ethz.ch

 

Effects of personalised exposure on self-rated electromagnetic hypersensitivity and sensibility – A double-blind randomised controlled trial

 

Imke van Moorselaar, Pauline Slottje, Pia Heller, Rob van Strien, Hans Kromhout, Manuel Murbach, Niels Kuster, Roel Vermeulen, and Anke Huss, Environment International, Volume 99, pp. 255–262, February 2017, online 9 December 2016, doi: 10.1016/j.envint.2016.11.031.

 
Other News

01/02/2017

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nk@itis.etzh.ch

 

Zurich43 Retreat 2017 at Pilatus Kulm - Communication

Twenty-five Zurich43 associates and three IT'IS Foundation board members gathered in the historic Hotel Pilatus-Kulm high above Luzern 30 – 31 January 2016 for their annual retreat, this year on communication. The goal of the two-day retreat was to find ways to improve communication skills across various target groups, channels, and markets, both within Z43 and with the outside world.

 
Other News

24/01/2017

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nk@itis.etzh.ch

 

X-TRA, X-TRA! Inaugural Zurich43 Party: X-TRAordinary Nine = X-TRAordinary Fun!

The 2017 Z43 annual party held at Zurich’s X-TRA concert hall celebrated the emerging corporate identity and global reach of the Z43 brand.

 
VIRTUAL POPULATION

20/01/2017

 

Successful NEUROMAN Project Start and Kickoff Meeting

Partners form Switzerland and Korea join forces to create first ever computational phantom with detailed neuronal networks.

 
PUBLICATIONS

15/01/2017

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nk@itis.ethz.ch

 

Terahertz reflectarrays and nonuniform metasurfaces

Daniel Headland, Tiaoming Niu, Eduardo Carrasco, Derek Abbott, Shruti Nirantar, Sharath Sriram, Madhu Bhaskaran, Christophe Fumeaux, and Withawat Withayachumnankul, IEEE J. Sel. Topics Quantum Electron., online 20 December 2016, DOI: 10.1109/JSTQE.2016.2640452

 
Other News

31/12/2016

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nk@itis.etzh.ch

 

Important Milestone in Cancer Therapy

As of January 2017, the Swiss Federal Office of Public Health (FOPH) will include hyperthermia treatment in combination with radiation therapy as covered therapy in the Swiss basic health insurance catalog.

 
Other News

18/12/2016

 

3D Atlas of Human Embryology

A team from the Academic Medical Center (AMC) in Amsterdam NL has published a comprehensive 3D Atlas of Human Embryology. The atlas is made freely available to the scientific community to facilitate embryology education and research.

 
Other News

25/11/2016

 

A Brain–Spine Interface Alleviating Gait Deficits after Spinal Cord Injury in Primates

Marco Capogrosso, Tomislav Milekovic, David Borton, Fabien Wagner, Eduardo Martin Moraud, Jean-Baptiste Mignardot, Nicolas Buse, Jerome Gandar, Quentin Barraud, David Xing, Elodie Rey, Simone Duis, Yang Jianzhong, Wai Kin D. Ko, Qin Li, Peter Detemple, Tim Denison, Silvestro Micera, Erwan Bezard, Jocelyne Bloch, and Grégoire Courtine, in Nature, Volume 539, Issue 7628, pp. 284 – 288, 9 November 2016

 
Other News

22/11/2016

 

Noninvasive Deep Brain Stimulation via Delivery of Temporally Interfering Electric Fields

Nir Grossman, David Bono, Suhasa Kodandaramaiah, Andrii Rudenko, Antonino Cassara, Esra Neufeld, Sheeba A. Anteraper, Atsushi Takahashi, Niels Kuster, Li-Huei Tsai, Alvaro Pascual-Leone, and Edward S. Boyden at the 46th annual meeting of the Society for Neuroscience, San Diego, CA, USA, November 12 – 16, 2016

 
Other News

14/11/2016

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nk@itis.etzh.ch

 

National Future Day 2016 – Gamma-Detector

On Thursday  November 10, six enthusiastic 11 – 13 year olds visited Z43 for Swiss National Future Day 2016, where they each manfactured a working gamma detector.

 
PUBLICATIONS

31/10/2016

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nk@itis.ethz.ch

 

From Image-Based Modeling to the Modeling of Imaging with the Virtual Population

Esra Neufeld, Bryn Lloyd, and Niels Kuster, in Simulation and Synthesis in Medical Imaging, Proceedings of the First International Workshop, SASHIMI 2016, Held in Conjunction with MICCAI 2016, Athens, Greece, October 21, 2016, Volume 9968 of the series Lecture Notes in Computer Science, pp. 45–54, online October, 2016

 
PUBLICATIONS

14/10/2016

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nk@itis.ethz.ch

 

Signaling by sulfur-containing molecules. Quantitative aspects.

Willem H. Koppenol and Patricia L. Bounds, Archives of Biochemistry and Biophysics, online September 23, 2016

 
PUBLICATIONS

12/10/2016

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nk@itis.ethz.ch

 

Magnetic Nanoparticle-Induced Hyperthermia with Appropriate Payloads: Paul Ehrlich’s “Magic (Nano)bullet” for Cancer Theranostics?

Nilroy R. Datta, Sunil Krishnan, Daniel E. Speiser, Esra Neufeld, Niels Kuster, Stefan Bodis, and Heinrich Hofmann,
Cancer Treatment Reviews, Volume 50, pp. 217–227, online September 2016

 
PUBLICATIONS

10/10/2016

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nk@itis.ethz.ch

 

Approach to Validate Simulation-Based Distribution Predictions Combining the Gamma-Method and Uncertainty Assessment: Application to Focused Ultrasound

Esra Neufeld, Adamos Kyriacou, Wolfgang Kainz, and Niels Kuster, Journal of Verification, Validation and Uncertainty Quantification, Volume 1, Issue 3, 031006, online September 2016

 
PRESS

23/09/2016

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nk@itis.ethz.ch

 

 
PUBLICATIONS

23/09/2016

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nk@itis.ethz.ch

 

Virtual Population-Based Assessment of the Impact of 3 Tesla Radiofrequency Shimming and Thermoregulation on Safety and B1+ Uniformity

Manuel Murbach, Esra Neufeld, Eugenia Cabot, Earl Zastrow, Juan Córcoles, Wolfgang Kainz, and Niels Kuster, Magnetic Resonance in Medicine, Volume 76, Issue 3, pp. 986–997, September 2016; Early View, September 2015, online September 24, 2015

 
Other News

24/08/2016

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nk@itis.etzh.ch

 

NTP Study Presented and Discussed at NIEHS Scientific Board Meeting

Following the press release on the US National Toxicology Program (NTP) Study of Cell Phone Radiofrequency Radiation (RFR) and Carcinogensis in May 2016, the presentation given by prinicpal investigator Michael Wyde on the setup and main preliminary findings is now accessible on our website.

 
ANNUAL REPORTS

15/08/2016

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nk@itis.ethz.ch

 

IT'IS Annual Report 2015

The Annual Report 2015 features news about the new Zurich43 corporate identity, key figures for 2015, and overviews of selected projects:

  • Focused Ultrasound Modeling to Enable Novel Therapeutic Applications 
  • Investigating EM-Induced Nerve Activation: Low Frequency Exposure Safety 
  • Turning Down the Heat in MRI for Patients with Implants 
  • New Approach for Realistic Posing of Anatomical Models 

 
PUBLICATIONS

15/08/2016

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nk@itis.ethz.ch

 

Parallel smoothing pressure correction solver for biomedical flow problems: convergence criteria, preconditioning, scalability

Kathrin Burckhardt, Dominik Szczerba, Esra Neufeld, Krishnamurthy Muralidhar, and Niels Kuster, Progress in Computational Fluid Dynamics, Volume 16, Issue 4, pp. 201–215, online August 10, 2016

 
VIRTUAL POPULATION

13/07/2016

Contact
vip@itis.ethz.ch

 

Release of New Posable Virtual Population Models V3.1!

IT’IS proudly announces the release of the full range of ViP models, now upgraded for use with the new Poser method available in the multiphysics computational life sciences platform Sim4Life 2.2!

 

 
Other News

30/06/2016

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nk@itis.etzh.ch

 

Latsis Symposium 2016 ETH Zurich on Personalized Medicine, June 27–29, 2016

The IT'IS Foundation joined forces with the Competence Center Personalized Medicine UZH/ETH to host the Latsis Symposium 2016 on Personalized Medicine at the ETH Zurich, June 27 – 29, 2016. More than 250 attendees assembled to explore a wide range of topics on research and policy in precision medicine with leading experts from clinics, universities, regulatory agencies, and industry. The event closed with a well-attended German-language public event on Wednesday evening, June 29.

 
Other News

10/06/2016

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nk@itis.ethz.ch

 

NIEHS Press Release on NTP Study of Cell Phone RF Radiation and Carcinogensis in Rats

The National Toxicology Program (NTP) of NIEHS released a report entitled, “Report of Partial Findings From the National Toxicology Program Carcinogenesis Studies of Cell Phone Radiofrequency Radiation in Hsd: Sprague Dawley SD Rats (Whole Body Exposure).” This was a joint study with the IT'IS Foundation.

 
PUBLICATIONS

07/06/2016

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nk@itis.ethz.ch

 

Investigation of assumptions underlying current safety guidelines on EM-induced nerve stimulation

Esra Neufeld, Ioannis Vogiatzis Oikonomidis, Maria Ida Iacono, Leonardo M. Angelone, Wolfgang Kainz, and Niels Kuster, Physics in Medicine and Biology, Volume 61, Issue 12, pp. 4466–4478, online May 2016

 
PUBLICATIONS

07/06/2016

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nk@itis.ethz.ch

 

Functionalized anatomical models for EM-neuron interaction modeling

Esra Neufeld, Antonino M. Cassara, Hazael Montanaro, and Niels Kuster, Physics in Medicine and Biology, Volume 61, Issue 12, 4390–4401, online May 25, 2016

 
AWARDS

23/05/2016

Contact
nk@itis.ethz.ch

 

IT’IS Wins Award for Best Poster in Session at the 2016 Annual Meeting of the International Society for Magnetic Resonance in Medicine

The IT'IS Foundation won the best poster award in a joint session on High Field Systems & Applications and MR Safety at the 24th Annual Meeting of the International Society for Magnetic Resonance in Medicine (ISMRM) in Singapore, 7 – 13 May 2016. Earl Zastrow presented the poster entitled "Development of a Set of Generic Numerical Birdcages for Comprehensive Evaluations of Induced RF Fields for Implant Safety."

 
PUBLICATIONS

18/05/2016

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nk@itis.ethz.ch

 

Comparative dosimetry for children and rodents exposed to extremely low-frequency magnetic fields

Yijian Gong, Myles Capstick, Clemens Dasenbrock, Maren Fedrowitz, Cesar Cobaleda, Isidro Sanchez-Garcia, and Niels Kuster, Bioelectromagnetics, Volume 37, Issue 5, pp. 310–322, July 2016, online May 13, 2016

 
PUBLICATIONS

17/05/2016

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nk@itis.ethz.ch

 

Pregnant women models analyzed for RF exposure and temperature increase in 3T RF shimmed birdcages

Manuel Murbach, Esra Neufeld, Theodoros Samaras, Juan Córcoles, Fraser J. Robb, Wolfgang Kainz, and Niels Kuster, Magnetic Resonance in Medicine, Early View, May 2016, online May 17, 2016

 
PUBLICATIONS

13/05/2016

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nk@itis.ethz.ch

 

Dielectric Resonator Reflectarray as High-Efficiency Nonuniform Terahertz Metasurface

Daniel Headland, Eduardo Carrasco, Shruti Nirantar, Withawat Withayachumnankul, Philipp Gutruf, James Schwarz, Derek Abbott, Madhu Bhaskaran, Sharath Sriram, Julien Perruisseau-Carrier, and Christophe Fumeaux, ACS Photonics, online May 13, 2016, DOI: 10.1021/acsphotonics.6b00102

 
PUBLICATIONS

01/04/2016

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nk@itis.ethz.ch

 

An HF exposure system for mice with improved efficiency

Myles Capstick, Yijian Gong, Boris Pasche, and Niels Kuster, Bioelectromagnetics, Volume 37, Issue 4, pp. 223–233, May 2016, online March 31, 2016

 
PUBLICATIONS

17/03/2016

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nk@itis.ethz.ch

 

Extremely low-frequency magnetic fields and the risk of childhood leukemia: A risk assessment by the ARIMMORA consortium

Joachim Schüz, Clemens Dasenbrock, Paolo Ravazzani, Martin Röösli, Primo Schär, Patricia L. Bounds, Friederike Erdmann, Arndt Borkhardt, César Cobaleda, Maren Fedrowitz, Yngve Hamnerius, Isidro Sanchez-Garcia, Rony Seger, Kjeld Schmiegelow, Gunde Ziegelberger, Myles Capstick, Melissa Manser, Meike Müller, Christoph D. Schmid, David Schürmann, Benjamin Struchen, and Niels Kuster, Bioelectromagnetics, Volume 37, Issue 3, pp. 183–189, April 2016, online March 15, 2016

 
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