NEWS
01/06/2017
PUBLICATIONS

Noninvasive Deep Brain Stimulation via Temporally Interfering Electric Fields

Nir Grossman, David Bono, Nina Dedic, Suhasa B. Kodandaramaiah, Andrii Rudenko, Ho-Jun Suk, Antonino M. Cassara, Esra Neufeld, Niels Kuster, Li-Huei Tsai, Alvaro Pascual-Leone, and Edward S. Boyden, CellVolume 169, Issue 6, pp. 1029–1041, online 1 June 2017, doi: 10.1016/j.cell.2017.05.024

The paper reports a noninvasive strategy for electrically stimulating neurons at depth. By delivering to the brain multiple electric fields at frequencies too high to recruit neural firing, but which differ by a frequency within the dynamic range of neural firing, it is possible to electrically stimulate neurons throughout a region where interference between the multiple fields results in a prominent electric field envelope modulated at the difference frequency. This temporal interference (TI) concept was validated via modeling and physics experiments, and it was verified that neurons in the living mouse brain could follow the electric field envelope. The utility of TI stimulation is demonstrated by stimulating neurons in the hippocampus of living mice without recruiting neurons of the overlying cortex. Finally, it is shown that by altering the currents delivered to a set of immobile electrodes, different motor patterns can be steerably evoked in living mice.

The scientific and technical impact of the study can be summarized as:

  • A new, noninvasive technique to stimulate deep brain structures has been developed and tested by using computational modeling and phantom measurements, as well as electrophysiological measurements in vivo;
  • TI stimulation sends interfering, low-frequency modulated, high frequency signals from multiple pairs of electrodes placed on the scalp through the brain, avoiding stimulation of other areas;
  • The results make TI stimulation a promising alternative to surgical electrical stimulation interventions such as deep brain stimulation (DBS) for e.g., Parkinson's disease patients.
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AWARDS

14/06/2013

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nk@itis.ethz.ch

 

Award for Best Scientific Paper Presented by a Student at BioEM2013

IT'IS PhD student Yijian Gong was awarded second place in the poster competition for Best Scientific Paper presented by a student at BioEM2013

 
AWARDS

22/05/2013

Contact
nk@itis.ethz.ch

 

Award for Best Presentation and Best Poster Contribution at the 4th International Workshop on Computational Phantoms for Radiation Protection, Imaging and Radiotherapy

IT’IS Young Scientists Win Three Student Awards at the 4th International Workshop on Computational Phantoms for Radiation Protection, Imaging and Radiotherapy

 
MAJOR EVENTS

22/05/2013

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nk@itis.ethz.ch

 

4th International Workshop on Computational Phantoms for Radiation Protection, Imaging and Radiotherapy

IT’IS and ETH host the 4th International Workshop on Computational Phantoms for Radiation Protection, Imaging and Radiotherapy

 
PUBLICATIONS

14/05/2013

Contact
nk@itis.ethz.ch

 

Simulation Techniques in Hyperthermia Treatment Planning

Margarethus Paulides, Paul Stauffer, Esra Neufeld, Paolo Maccarini, Adamos Kyriakou, Richard Canters, Chris Diederich, Jurriaan Bakker, and Gerard van Rhoon, International Journal of Hyperthermia, Volume 29, Issue 4, pp. 346–357, June 2013, online May 14, 2013

 

 
AWARDS

02/05/2013

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nk@itis.ethz.ch

 

Travel Award for the 2013 ISTU Symposium

Adamos Kyriakou has been awarded a travel award to attend the 2013 ISTU Symposium.

 
PUBLICATIONS

29/04/2013

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nk@itis.ethz.ch

 

Assessing Human Exposure to Electromagnetic Fields From Wireless Power Transmission Systems

Andreas Christ, Mark Douglas, Jagadish Nadakuduti, and Niels Kuster, Proceedings of the IEEE , Volume 101, Issue 6, pp. 1482-1493, June 2013, online March 13, 2013

 

 
PUBLICATIONS

29/04/2013

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nk@itis.ethz.ch

 

Li (2013) Thesis

Chung-Huan Li, “Contributions Towards Optimized Antennas for On-Body Operation”, PhD Thesis, Swiss Federal Insititute of Technology, Thesis No. 21004, Zurich, 2013

 
PUBLICATIONS

19/04/2013

Contact
nk@itis.ethz.ch

 

IARC Monographs Vol. 102

Today, the International Agency for Research on Cancer (IARC) has finally published the overdue IARC Monographs Vol. 102 on ‘Non-Ionizing Radiation, Part 2: Radiofrequency Electromagnetic Fields‘.

 
PUBLICATIONS

19/04/2013

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nk@itis.ethz.ch

 

Antenna Design and Tissue Parameters Considerations for Improved Modelling of Microwave Ablation in the Liver

Andreas Karampatzakis, Sven Kühn, George Tsanidis, Esra Neufeld, Theodoros Samaras, and Niels Kuster, Physics in Medicine and Biology, Volume 58, Issue 10, pp. 3191–3206, May 2013, online April 19, 2013 

 

 
PUBLICATIONS

17/04/2013

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nk@itis.ethz.ch

 

CEM43°C Thermal Dose Thresholds: A Potential Guide for Magnetic Resonance Radiofrequency Exposure Levels?

Gerard C. van Rhoon, Theodoros Samaras, Pavel S. Yarmolenko, Mark W. Dewhirst, Esra Neufeld, and Niels Kuster, European Radiology, Volume 23, Issue 8, pp. 2215-2227, August 2013, online April, 2013

 
Other News

12/04/2013

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nk@itis.ethz.ch

 

Successful Finalization of the SEAWIND Project

Three years after its start, the SEAWIND project was successfully finalized.

 
Other News

07/04/2013

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nk@itis.ethz.ch

 

IT'IS @ Treffpunkt City Science

IT'IS exhibits at the 2013 Treffpunk City Science event "Communication - Digital and Networked”.  

 
PUBLICATIONS

26/03/2013

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nk@itis.ethz.ch

 

Analysis of Mobile Phone Design Features Affecting Radio-frequency Power Absorbed in a Human Head Phantom

Sven Kühn, Michael Kelsh, Niels Kuster, Asher Sheppard, and Mona Shum, Bioelectromagnetics, Volume 34, Issue 6, pp. 479–488, September 2013, online March 26, 2013

 

 
PUBLICATIONS

15/03/2013

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nk@itis.ethz.ch

 

Stimulation of the Brain with Radiofrequency Electromagnetic Field Pulses Affects Sleep-Dependent Performance Improvement

Caroline Lustenberger, Manuel Murbach, Roland Dürr, Marc R. Schmid, Niels Kuster, Peter Achermann, and Reto Huber, Brain Stimulation, Volume 6, Issue 5, pp. 805-811, September 2013, online February 26, 2013

 
PUBLICATIONS

11/03/2013

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nk@itis.ethz.ch

 

Whole-Body and Local RF Absorption in Human Models as a Function of Anatomy and Position within 1.5T MR Body Coil

Manuel Murbach, Esra Neufeld, Wolfgang Kainz, Klaas P. Pruessmann, and Niels Kuster, Magnetic Resonance in Medicine, Volume 71, Issue 2, pp. 839-845, February 2014, online February 25, 2013

 
PUBLICATIONS

25/02/2013

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nk@itis.ethz.ch

 

No Increased Sensitivity in Brain Activity of Adolescents Exposed to Mobile Phone-Like Emissions

Sarah P. Loughran, Dominik Benz, Marc Schmid, Manuel Murbach, Niels Kuster, and Peter Achermann, Clinical Neurophysiology, Volume 124, Issue 7, pp. 1303-1308, July 2013, online February 20, 2013

 

 
PUBLICATIONS

19/02/2013

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nk@itis.ethz.ch

 

Thermal Tissue Damage Model Analyzed for Different Whole-Body SAR and Scan Durations for Standard MR Body Coils

Manuel Murbach, Esra Neufeld, Myles Capstick, Wolfgang Kainz, David O. Brunner, Theodoros Samaras, Klaas P. Pruessmann, and Niels Kuster, Magnetic Resonance in Medicine, Volume 71, Issue 1, pp. 421-431, January 2014, online February 14, 2013

 
PUBLICATIONS

18/02/2013

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nk@itis.ethz.ch

 

Analysis of Human Brain Exposure to Low-Frequency Magnetic Fields: A Numerical Assessment of Spatially Averaged Electric Fields and Exposure Limits

Xi Lin Chen, Stefan Benkler, Nicholas Chavannes, Valerio De Santis, Jurriaan Bakker, Gerard van Rhoon, Juan Mosig, and Niels Kuster, Bioelectromagnetics, Volume 34, Issue 5, pp. 375-384, July 2013, February 12, 2013

 
Other News

12/02/2013

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nk@itis.etzh.ch

 

Electrified into 2013

The most spectacular Annual Party in recent memory: the IT'IS - Speag - ZMT "Electrified into 2013" Party.

 
PUBLICATIONS

31/01/2013

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nk@itis.ethz.ch

 

Influence of GSM Signals on Human Peripheral Lymphocytes: Study of Genotoxicity

Petra Waldmann, Susanne Bohnenberger, Rüdiger Greinert, Beate Hermann-Then, Anja Heselich, Stefanie J. Klug, Jochem Koenig, Kathrin Kuhr, Niels Kuster, Mandy Merker, Manuel Murbach, Dieter Pollet, Walter Schadenboeck, Ulrike Scheidemann-Wesp, Britt Schwab, Beate Volkmer, Veronika Weyer, and Maria Blettner, Radiation Research, Volume 179, Issue 4, pp. 243-253, April 2013, online January 14, 2013

 
PUBLICATIONS

28/01/2013

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nk@itis.ethz.ch

 

Cell Type-Dependent Induction of DNA Damage by 1800 MHz Radiofrequency Electromagnetic Fields Does Not Result in Significant Cellular Dysfunctions

Shanshan Xu, Guangdi Chen, Chunjing Chen, Chuan Sun, Danying Zhang, Manuel Murbach, Niels Kuster, Qunli Zeng, and Zhengping Xu, PLoS ONE, Volume 8, Issue 1, online ahead of print January 23, 2013

 
Other News

30/11/2012

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nk@itis.etzh.ch

 

Innovation Retreat

The success and achievements of the Bell Labs have inspired generations of engineers, physicists, product developers, and other scientists. These accomplishments and the success stories of our greatest inventors have also inspired 21 Speag, ZMT, and IT'IS coworkers who gathered in Flüeli-Ranft on Novenber 22nd-23rd to get under the hood of our our own innovation engine.

 
PUBLICATIONS

15/11/2012

Contact
nk@itis.ethz.ch

 

Field Evaluation of the Human Exposure from Multi-Band, Multi-System Mobile Phones

Sven Kühn, and Niels Kuster, IEEE Transactions Electromagnetics Compatibility, Volume 55, Issue 2, pp. 275-287, April 2013, online November 15, 2012

 

 
Other News

08/11/2012

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nk@itis.etzh.ch

 

Parents back to school: kids take over

On the 2012 National Future Day, four outstanding girls – Anushka, Chimey, Liza, and Sia, and four exceptional boys – Jechiel, Kilian, Moritz, and Arun joined our research and development teams at IT'IS, SPEAG and ZMT for one day.

 
PUBLICATIONS

01/11/2012

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nk@itis.ethz.ch

 

ELF Exposure System for Live Cell Imaging

Myles Capstick, Primo Schär, David Schürmann, Albert Romann, and Niels Kuster, Bioelectromagnetics, online ahead of print November 01, 2012

 
PUBLICATIONS

26/10/2012

Contact
nk@itis.ethz.ch

 

Bakker (2012) Thesis

Jurriaan Bakker, "Dosimetry of Exposure to Electromagnetic Fields in Daily Life and Medical Applications", PhD Thesis, Erasmus MC - Daniel den Hoed Cancer Center, Rotterdam, 2012, online November 2012

 
PUBLICATIONS

25/10/2012

Contact
nk@itis.ethz.ch

 

Evaluation of Wireless Resonant Power Transfer Systems With Human Electromagnetic Exposure Limits

Andreas Christ, Mark G. Douglas, John Roman, Emily B. Cooper, Alanson P. Sample, Benjamin H. Waters, Joshua R. Smith and Niels Kuster, IEEE Transactions on Electromagnetic Compatibility, Volume 55, Issue 2, pp. 265-274, April 2013, online October 25, 2012

 
AWARDS

25/10/2012

Contact
nk@itis.ethz.ch

 

Award for Best Presentation at the International Workshop on EMF Health Risk Research

IT’IS collaborator Caroline Lustenberg wins the award for best presentation at the International Workshop on EMF Health Risk Research

 
AWARDS

25/10/2012

Contact
nk@itis.ethz.ch

 

Award for Best Poster Contribution at the International Workshop on EMF Health Risk Research

IT'IS/ETH PhD student Marie-Christine Gosselin wins the award for the best poster contribution at the International Workshop on EMF Health Risk Research

 
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