NEWS
01/06/2017
PUBLICATIONS

Noninvasive Deep Brain Stimulation via Temporally Interfering Electric Fields

Nir Grossman, David Bono, Nina Dedic, Suhasa B. Kodandaramaiah, Andrii Rudenko, Ho-Jun Suk, Antonino M. Cassara, Esra Neufeld, Niels Kuster, Li-Huei Tsai, Alvaro Pascual-Leone, and Edward S. Boyden, CellVolume 169, Issue 6, pp. 1029–1041, online 1 June 2017, doi: 10.1016/j.cell.2017.05.024

The paper reports a noninvasive strategy for electrically stimulating neurons at depth. By delivering to the brain multiple electric fields at frequencies too high to recruit neural firing, but which differ by a frequency within the dynamic range of neural firing, it is possible to electrically stimulate neurons throughout a region where interference between the multiple fields results in a prominent electric field envelope modulated at the difference frequency. This temporal interference (TI) concept was validated via modeling and physics experiments, and it was verified that neurons in the living mouse brain could follow the electric field envelope. The utility of TI stimulation is demonstrated by stimulating neurons in the hippocampus of living mice without recruiting neurons of the overlying cortex. Finally, it is shown that by altering the currents delivered to a set of immobile electrodes, different motor patterns can be steerably evoked in living mice.

The scientific and technical impact of the study can be summarized as:

  • A new, noninvasive technique to stimulate deep brain structures has been developed and tested by using computational modeling and phantom measurements, as well as electrophysiological measurements in vivo;
  • TI stimulation sends interfering, low-frequency modulated, high frequency signals from multiple pairs of electrodes placed on the scalp through the brain, avoiding stimulation of other areas;
  • The results make TI stimulation a promising alternative to surgical electrical stimulation interventions such as deep brain stimulation (DBS) for e.g., Parkinson's disease patients.
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MAJOR EVENTS

22/10/2012

Contact
nk@itis.ethz.ch

 

EMF Health Risk Research: Lessons Learned and Recommendations for the Future – 7 years later

More than 120 researchers, government and health agency representatives, and industrial partners from around the world gathered on Monte Verità for four days of presentations and discussions on interactions mechanisms between EMF and living organisms, on the knowledge gaps that remain to be filled, and on the research required to successfully corroborate or refute existing hypotheses.

 
PUBLICATIONS

16/10/2012

Contact
nk@itis.ethz.ch

 

The Effect of Diode Response of Electromagnetic Field Probes for the Measurements of Complex Signals

Jagadish Nadakuduti, Sven Kuehn, Marcel Fehr, Mark Douglas, Katja Pokovic, and Niels Kuster, IEEE Transactions on Electromagnetic Compatibility, Volume 54, Issue 6, pp. 1195-1204, December 2012, online October 16

 
PUBLICATIONS

11/10/2012

Contact
nk@itis.ethz.ch

 

Evaluation of the RF Heating of a Generic Deep Brain Stimulator Exposed in 1.5 T Magnetic Resonance Scanners

Eugenia Cabot, Tom Lloyd, Andreas Christ, Wolfgang Kainz, Mark Douglas, Gregg Stenzel, Steve Wedan, and Niels Kuster, Bioelectromagnetics, Volume 34, Issue 2, pp. 104-113, February 2013, online October 11

 
PUBLICATIONS

01/10/2012

Contact
nk@itis.ethz.ch

 

Experimental Evaluation of the SAR Induced in Head Phantoms of Three- and Eight-Year-Old Children

Marie-Christine Gosselin, Sven Kühn, Andreas Christ, Marcel Zefferer, Emilio Cherubini, Jurriaan F. Bakker, Gerard C. van Rhoon, and Niels Kuster, IEICE Transactions on Communications, Volume E95-B, Number 10, pp. 3215–3224, October 2012

 
AWARDS

21/09/2012

Contact
cabot@itis.ethz.ch

 

Best Paper Award at ECM Europe 2012

Takashi Hikage, Yoshifumi Kawamura, Toshio Nojima and IT'IS Foundation's Eugenia Cabot received the Best Paper Award at the EMC Europe 2012 held in Rome, Italy

 
AWARDS

31/08/2012

 

Young Investigator Award at ICHO & JCTM 2012

IT'IS PhD student Adamos Kyriacou won the Young Investigator Award at the combined meetings of the 11th International Congress of Hyperthermic Oncology and the 29th Japanese Congress of Thermal Medicine (ICHO & JCTM 2012) held in Kyoto, Japan

 
PRESS

24/07/2012

Contact
nk@itis.ethz.ch

 

The Washington Times Dedicates a Column to the 2012 Workshop on EMF and Health Risk Research Organized by IT'IS

The Washington Times dedicates a column to the IT'IS organized workshop on "EMF Health Risk Research: Lessons Learned and Recommendations for the Future" to be held from October 21–26, 2012 in Monte Verità, Ascona, Switzerland.

 
PUBLICATIONS

22/06/2012

Contact
murbach@itis.ethz.ch

 

Sleep EEG Alterations: Effects of Pulsed Magnetic Fields Versus Pulse-Modulated Radio Frequency Electromagnetic Fields

Marc R. Schmid, Manuel Murbach, Caroline Lustenberger, Micheline Maire, Niels Kuster, Peter Achermann, and Sarah P. Loughran, Journal of Sleep Research, Volume 21, Issue 6, pp. 620-629, December 2012, online June 22

 
AWARDS

19/06/2012

Contact
nk@itis.ethz.ch

 

Niels Kuster Receives Distinguished d'Arsonval Award

Niels Kuster received the highest scientific honor of the Bioelectromagnetics Society on June 19, 2012 at the 34th Annual Meeting in Brisbane, Australia

 
PUBLICATIONS

18/06/2012

Contact
nk@itis.ethz.ch

 

Mechanisms of RF Electromagnetic Field Absorption in Human Hands and Fingers

Chung-Huan Li, Mark Douglas, Erdem Ofli, Nicolas Chavannes, Quirino Balzano, and Niels Kuster, IEEE Transactions on Microwave Theory and Techniques, Volume 60, Issue 7, pp. 2267–2276, July 2012, online June 26

 
PUBLICATIONS

02/06/2012

Contact
nk@itis.ethz.ch

 

A Novel Approach for Mobile Device Design: GA-Based Distributed Optimization to Comply with OTA, SAR, and HAC Standards

Xi Lin Chen, Erdem Ofli, Nicolas Chavannes, and Niels Kuster, IEEE Antennas and Propagation Magazine, Volume 54, Issue 1, pp. 22–31, February 2012, online June 1

 
PUBLICATIONS

01/06/2012

Contact
nk@itis.ethz.ch

 

Exposure of the Human Body to Professional and Domestic Induction Cooktops Compared to the Basic Restrictions

Andreas Christ, René Guldimann, Barbara Bühlmann, Marcel Zefferer, Jurriaan F. Bakker, Gerard C. van Rhoon, and Niels Kuster, Bioelectromagnetics, Volume 33, Issue 8, pp. 695-705, December 2012, online June 1

 
ANNUAL REPORTS

31/05/2012

Contact
sponsor@itis.ethz.ch

 

IT'IS for Health: Advanced Research for Personalized Medicine

The IT'IS for Health brochure features:

  • Information Technology for Your Health: An Interview with Niels Kuster
  • Investing in Scientific Discovery, Advanced Technology, and Human Health
  • Anatomical Models for Research and Clinical Applications
  • Conversing with Cells
  • From Molecular- to Micro- to Macro-Biology

 
ANNUAL REPORTS

30/05/2012

Contact
nk@itis.ethz.ch

 

IT'IS Annual Report 2011

The Annual Report 2011 features key figures for 2011 and overviews of selected projects:

  • Live Cell Imaging during Electromagnetic Exposure
  • Novel Time-Domain Electric and Magnetic Field Probes
  • Modeling of Focused Ultrasound Inside the Human Body
  • Modeling EM-Neuron Interactions for Neuroprosthetics and Safety Assessment
  • Exposure Evaluations of Emerging Technologies

 
AWARDS

15/05/2012

Contact
nk@itis.ethz.ch

 

Niels Kuster d'Arsonval Award Winner for 2012

The Bioelectromagnetics Society (BEMS) website has announced that Niels Kuster, Director of IT'IS Foundation and Professor of the ETH Zurich has been selected to receive the distinguished d'Arsonval Award

 

 
Other News

27/04/2012

Contact
capstick@itis.ethz.ch

 

NIEHS Systems at IITRI Updated

During the last few weeks, Dr. Myles Capstick from IT'IS has updated the NIEHS system located at IITRI in Chicago, USA for higher power, and recalibrated all sensors after the pilot and pre-chronic studies were completed last year.

 
AWARDS

25/04/2012

Contact
nk@itis.ethz.ch

 

IT'IS Paper Most Cited of PMB from the Last 2 Years (2010–2012)

IT'IS's Virtual Family paper is the most cited paper of the journal Physics in Medicine and Biology from the last 2 years

 

 
Other News

03/04/2012

Contact
kuehn@itis.ethz.ch

 

NIS-Monitoring Schweiz: Eine Konzept- und Machbarkeitsstudie

Report of the feasibility study that presents the scientific basis for monitoring approaches to assess the human exposure to non-ionizing radiation (NIR). The developed concepts aim at the assessment of typical doses of non-ionizing radiation (NIR) in the Swiss population

 
PUBLICATIONS

29/03/2012

Contact
nk@itis.ethz.ch

 

Nikoloski (2011) Thesis

Neviana Nikoloski, “EMF Risk Assessment: Exposure Assessment and Specialized Exposure Setups,” PhD Thesis, Swiss Federal Insititute of Technology, Thesis No. 19939, Zurich, 2011, online March 2012

 
VIRTUAL POPULATION

21/03/2012

Contact
vip@itis.ethz.ch

 

Virtual Family Models Presented as a Key Topic by the U.S. Chief Technology Officer

On February 6, 2012 the National Modeling and Simulation Coalition held their inaugural congress. The opening presentation by the keynote speaker Aneesh Chopra, assistant to Barack Obama and U.S. Chief Technology Officer, presented the Virtual Family as part of a key topic: the Virtual Physiological Patient.

 

 
PUBLICATIONS

13/03/2012

Contact
nk@itis.ethz.ch

 

Children and Adults Exposed to Low Frequency Magnetic Fields at the ICNIRP Reference Levels: Theoretical Assessment of the Induced Electric Fields

Jurriaan F. Bakker, Maarten M. Paulides, Esra Neufeld, Andreas Christ, Xi Lin Chen, Niels Kuster, and Gerard van Rhoon, Physics in Medicine and Biology, Volume 57, Number 7, pp. 1815–1829, April 2012, online March 13

 
Other News

01/03/2012

 

Template other news item

Brief version

 
PUBLICATIONS

13/02/2012

Contact
nk@itis.ethz.ch

 

Exposure System to Study Hypotheses of ELF and RF Electromagnetic Field Interactions of Mobile Phones With the Central Nervous System

Manuel Murbach, Maria Christopoulou, Pedro Crespo-Valero, Peter Achermann, and Niels Kuster, Bioelectromagnetics, Volume 33, Issue 6, pp. 527–533, September 2012, online February 13

 
PUBLICATIONS

20/01/2012

Contact
nik@itis.ethz.ch

 

Parallelization of the FDTD Method Based on the Open Computing Language and the Message Passing Interface

Tomasz P. Stefanski, Nicolas Chavannes, and Niels Kuster, in Microwave and Optical Technology Letters, Volume 54, Issue 3, pp. 785–789, March 2012, online January 20

 
PUBLICATIONS

10/01/2012

Contact
nk@itis.ethz.ch

 

Patient-Specific Simulations and Measurements of the Magneto-Hemodynamic Effect in Human Primary Vessels

Adamos Kyriakou, Esra Neufeld, Dominik Szczerba, Wolfgang Kainz, Roger Luechinger, Sebastien Kozerke, Robert McGregor, and Niels Kuster, Physiological Measurement, Volume 33, Issue 2, pp. 117–130, February 2012, online January 6

 
PRESS

09/01/2012

Contact
nk@itis.ethz.ch

 

The Observer Highlights Research on EMF and Cancer Treatment

The Guardian dedicated a column to the latest research on EMF and cancer treatment published in the British Journal of Cancer by Boris Pache and co-authors. This research was performed in collaboration with IT'IS. 

 
Other News

27/12/2011

Contact
payne@itis.ethz.ch

 

EMF Health Risk Research – Lessons Learned and Recommendations for the Future – Seven Years Later

The IT’IS Foundation is pleased to announce the 2012 EMF Health Risk Research – Lessons Learned and Recommendations for the Future workshop. This workshop will take place from the 21st to the 26th of October 2012 in Monte Verità, Ascona, Switzerland

 
PUBLICATIONS

02/12/2011

Contact
nk@itis.ethz.ch

 

Cancer Cell Proliferation is Inhibited by Specific Modulation Frequencies

Jacquelyn W. Zimmerman, Michael J. Pennison, Ivan Brezovich, Nengjun Yi, Celeste T. Yang, Ryne Ramaker, Devin Absher, Richard M. Myers, Niels Kuster, Frederico P. Costa, Alexandre Barbault, and Boris Pasche, British Journal of Cancer, Volume 106, Issue 2, pp. 307–313, January 17, 2012. Online December 1, 2011

 
PRESS

01/12/2011

Contact
nk@itis.ethz.ch

 

Inside View of the IARC Monograph Meeting 102

The procedures of the IARC Monograph Program are described in the article, "The Eyes of the World Were Upon Us – An Inside View of the IARC Monograph Meeting 102: Evaluation of the Carcinogenic Risks of RF-EMF to Humans" by Meike Mevissen and Christopher J. Portier

 
PUBLICATIONS

21/11/2011

Contact
nk@itis.ethz.ch

 

Local Tissue Temperature Increase of a Generic Implant Compared to the Basic Restrictions Defined in Safety Guidelines

Adamos Kyriakou, Andreas Christ, Esra Neufeld, and Niels Kuster, Bioelectromagnetics, Volume 33, Issue 5, pp. 366–374, July 2012, online November 21

 
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