NEWS
01/06/2017
PUBLICATIONS

Noninvasive Deep Brain Stimulation via Temporally Interfering Electric Fields

Nir Grossman, David Bono, Nina Dedic, Suhasa B. Kodandaramaiah, Andrii Rudenko, Ho-Jun Suk, Antonino M. Cassara, Esra Neufeld, Niels Kuster, Li-Huei Tsai, Alvaro Pascual-Leone, and Edward S. Boyden, CellVolume 169, Issue 6, pp. 1029–1041, online 1 June 2017, doi: 10.1016/j.cell.2017.05.024

The paper reports a noninvasive strategy for electrically stimulating neurons at depth. By delivering to the brain multiple electric fields at frequencies too high to recruit neural firing, but which differ by a frequency within the dynamic range of neural firing, it is possible to electrically stimulate neurons throughout a region where interference between the multiple fields results in a prominent electric field envelope modulated at the difference frequency. This temporal interference (TI) concept was validated via modeling and physics experiments, and it was verified that neurons in the living mouse brain could follow the electric field envelope. The utility of TI stimulation is demonstrated by stimulating neurons in the hippocampus of living mice without recruiting neurons of the overlying cortex. Finally, it is shown that by altering the currents delivered to a set of immobile electrodes, different motor patterns can be steerably evoked in living mice.

The scientific and technical impact of the study can be summarized as:

  • A new, noninvasive technique to stimulate deep brain structures has been developed and tested by using computational modeling and phantom measurements, as well as electrophysiological measurements in vivo;
  • TI stimulation sends interfering, low-frequency modulated, high frequency signals from multiple pairs of electrodes placed on the scalp through the brain, avoiding stimulation of other areas;
  • The results make TI stimulation a promising alternative to surgical electrical stimulation interventions such as deep brain stimulation (DBS) for e.g., Parkinson's disease patients.
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Other News

10/11/2011

 

Our Future Researchers?

On the 2011 National Future Day, Anushka, Chimey, Jil and Liza joined our research and development teams at IT'IS and SPEAG for one day.

 
PUBLICATIONS

21/10/2011

Contact
douglas@itis.ethz.ch

 

Influence of the Hand on the Specific Absorption Rate in the Head

Chung-Huan Li, Mark Douglas, Erdem Ofli, Benoit Derat, Sami Gabriel, Nicolas Chavannes, and Niels Kuster, IEEE Transactions on Antennas and Propagation, Volume 60, Issue 2, pp. 1066–1074, February 2012, online October 21, 2011

 
Other News

02/10/2011

Contact
szankowski@itis.ethz.ch

 

ARIMMORA Project Commenced

Advanced Research on Interaction Mechanisms of electroMagnetic Exposures with Organisms for Risk Assessment. The FP7 ARIMMORA project has officially begun on October 1, 2011

 

 
VIRTUAL POPULATION

29/09/2011

Contact
vip@itis.ethz.ch

 

Tissue Properties Database Online

The IT'IS Foundation is proud to announce the launch of an online database for thermal and dielectric parameters of biological tissues as part of its ongoing effort to provide the community with a series of highly detailed anatomical models: the Virtual Population.

 

 
Other News

27/09/2011

Contact
nk@itis.ethz.ch

 

New Chinese Electromagnetics Research Program

A new five year EMF research program by Chinese Government chaired by Professor Yu Zhengping at the Third Military Medical University, China, has started in January 2011. Some of the research will be performed using exposure systems of the IT'IS Foundation.

 
PUBLICATIONS

22/09/2011

Contact
murbach@itis.ethz.ch

 

Local SAR Enhancements in Anatomically Correct Children and Adult Models as a Function of Position within 1.5T MR Body Coil

Manuel Murbach, Eugenia Cabot, Esra Neufeld, Marie-Christine Gosselin, Andreas Christ, Klaas Prüssmann, and Niels Kuster, Progress in Biophysics and Molecular Biology, Volume 107, Issue 3, pp. 428–433, December, 2011. Online September 22

 
AWARDS

07/09/2011

Contact
neufeld@itis.ethz.ch

 

British Journal of Cancer Top Ten Most Downloaded Articles

The Boris Pasche group paper, coauthored with IT'IS's Niels Kuster, has become one of the top ten most downloaded articles within two weeks of publication by the British Journal of Cancer.

 
PUBLICATIONS

31/08/2011

Contact
douglas@itis.ethz.ch

 

Application of an Induced Field Sensor for Assessment of Electromagnetic Exposure from Compact Fluorescent Lamps

Jagadish Nadakuduti, Mark Douglas, Myles Capstick, Sven Kühn, and Niels Kuster, Bioelectromagnetics, Volume 33, Issue 2, pp. 166–175, February 2012. Online August 31, 2011

 
PUBLICATIONS

15/08/2011

Contact
nk@itis.ethz.ch

 

Mechano-Chemical Simulation of a Solid Tumor Dynamics for Therapy Outcome Predictions

Sven Hirsch, Dominik Szczerba, Bryn Lloyd, Michael Bajka, Niels Kuster, and Gabor Szekely, International Journal for Multiscale Computational Engineering, Volume 9, Issue 2, pp. 231–241, 2011, online August 15

 
PUBLICATIONS

12/08/2011

Contact
nk@itis.ethz.ch

 

Head Exposure System for a Human Provocation Study to Assess the Possible Influence of UMTS-Like Electromagnetic Fields on Cerebral Blood Circulation Using Near-Infrared Imaging

Hugo Lehmann, Laurent Pollara, Sonja Spichtig, Sven Kühn, and Martin Wolf, Bioelectromagnetics, Volume 33, Issue 2, pp. 124–133, February 2012. Online August 12, 2011

 
PUBLICATIONS

09/08/2011

Contact
nk@itis.ethz.ch

 

Treatment of Advanced Hepatocellular Carcinoma with Very Low Levels of Amplitude-Modulated Electromagnetic Fields

Frederico P. Costa, André Cosme de Oliveira, Roberto Meirelles, Marcel C.C. Machado, Tatiana Zanesco, Rodrigo Surjan, Maria Cristina Chammas, Manoel de Souza Rocha, Desiree Morgan, Alan Cantor, Jacquelyn Zimmerman, Ivan Brezovich, Niels Kuster, Alexandre Barbault, and Boris Pasche, British Journal of Cancer, Volume 105, Number 5, pp. 640–648, August 23, 2011. Online August 9

 
PUBLICATIONS

15/07/2011

Contact
nk@itis.ethz.ch

 

Children and Adults Exposed to Electromagnetic Fields at the ICNIRP Reference Levels: Theoretical Assessment of the Induced Peak Temperature Increase

Jurriaan F. Bakker, Margarethus M. Paulides, Esra Neufeld, Andreas Christ, Niels Kuster, Gerard C. van Rhoon, Physics in Medicine and Biology, Volume 56, Number 15, pp. 4967–4990, August, 2011, online July 19

 
PUBLICATIONS

06/07/2011

Contact
neufeld@itis.ethz.ch

 

Analysis of the Local Worst-Case SAR Exposure Caused by an MRI Multi-Transmit Body Coil in Anatomical Models of the Human Body

Esra Neufeld, Marie-Christine Gosselin, Manuel Murbach, Andreas Christ, Eugenia Cabot and Niels Kuster, Physics in Medicine and Biology, Volume 56, Number 15, pp. 4649–4659, August, 2011, online July 6

 
PUBLICATIONS

05/07/2011

Contact
nk@itis.ethz.ch

 

Estimation Formulas for the Specific Absorption Rate in Humans Exposed to Base Station Antennas

Marie-Christine Gosselin, Günter Vermeeren, Sven Kühn, Valpré Kellerman, Stefan Benkler, Tero M. I. Uusitupa, Wout Joseph, Azeddine Gati, Joe Wiart, Frans J. C. Meyer, Luc Martens, Toshio Nojima, Takashi Hikaje, Quirino Balzano, Andreas Christ, Niels Kuster, IEEE Transactions on Electromagnetic Compatibility, Volume 53, Issue 4, pp. 909–922, November 2011, online June 9

 
AWARDS

30/06/2011

Contact
nk@itis.ethz.ch

 

IT'IS Paper Among 5 Most Cited Papers of PMB in 2010

An IT'IS paper is among the five most cited papers in 2010 of the journal Physics in Medicine and Biology (PMB)

 
Other News

22/06/2011

Contact
nk@itis.ethz.ch

 

Carcinogenicity of Radiofrequency Electromagnetic Fields

Robert Baan, Yann Grosse, Béatrice Lauby-Secretan, Fatiha El Ghissassi, Véronique Bouvard, Lamia Benbrahim-Tallaa, Neela Guha, Farhad Islami, Laurent Galichet, Kurt Straif, The Lancet Oncology (Early Online Publication), June 22, 2011

 
AWARDS

17/06/2011

Contact
gosselin@itis.ethz.ch

 

Joseph James Morrissey Memorial Award for First Place Student Platform Presentation

Marie Christine Gosselin received the first place BEMS Student Award for Best Platform Presentation, the Joseph James Morrissey Memorial Award, at the 2011 meeting of the Bioelectromagnetics Society (BEMS2011), in Halifax, Nova Scotia, Canada

 
AWARDS

15/06/2011

Contact
neufeld@itis.ethz.ch

 

Roberts Prize for Best Paper in 2010 in Physics in Medicine and Biology

Maarten Paulides and Esra Neufeld's paper was awarded the Roberts Prize for Best Paper in 2010 of the IOP journal: Physics in Medicine and Biology

 
ANNUAL REPORTS

13/06/2011

Contact
nk@itis.ethz.ch

 

IT'IS Annual Report 2010

The Annual Report 2010 features key figures for 2010 and overviews of selected projects:

  • Novel EM Instrumentation
  • Exposure of the Fetus
  • Dynamically Morphing Anatomical Models
  • Analyzing the Magneto-Hemodynamic Effect
  • Magnetic Nanoparticle Hyperthermia Applicator for Cancer Therapy

 
PRESS

31/05/2011

Contact
info@itis.ethz.ch

 

IARC Classifies RF EMF as Possibly Carcinogenic to Humans

The International Agency for Research on Cancer (IARC) of WHO has classified radiofrequency electromagnetic fields as possibly carcinogenic to humans (Group 2B), based on an increased risk for glioma, a malignant type of brain cancer, associated with wireless phone use.

 
Other News

31/05/2011

Contact
nk@itis.ethz.ch

 

IEC 62232 Base Station Standard Finalized

The International Electrotechnical Commission's international standard IEC 62232 was concluded this year with a 100% approval vote

 
PRESS

12/05/2011

Contact
nk@itis.ethz.ch

 

Press Conference: National Research Programme "Non-Ionising Radiation – Health and Environment" (NRP 57)

The Swiss National Science Foundation (SNSF) organized a national press conference on May 12, 2011, to present the results of the National Research Programme "Non-Ionising Radiation – Health and Environment" (NRP 57) to the general public.

 
PUBLICATIONS

19/04/2011

Contact
dominik@itis.ethz.ch

 

GPU-Based Simulation of 3D Blood Flow in Abdominal Aorta Using OpenFOAM

Ziemowit Malecha, Lukasz Miroslaw, Tadeusz Tomczak, Zbigniew Koza, Maciej Matyka, Wojciech Tarnawski, and Dominik Szczerba, in Archives of Mechanics, Volume 63, Issue 2, pp. 137–161, April 2011. Paper presented at 19th Polish National Fluid Dynamics Conference (KKMP), Poznan, Poland, September 5–9, 2010, online April 19, 2011

 
PUBLICATIONS

12/04/2011

Contact
nk@itis.ethz.ch

 

Sleep EEG Alterations: Effects of Different Pulse-Modulated Radio Frequency Electromagnetic Fields

Marc R. Schmid, Sarah P. Loughran, Sabine J. Regel, Manuel Murbach, Aleksandra Bratic Grunauer, Thomas Rusterholz, Alessia Bersagliere, Niels Kuster, and Peter Achermann, Journal of Sleep Research, Volume 21, Issue 1, pp. 50–58, February, 2012, online April 12, 2011

 
AWARDS

07/04/2011

Contact
nk@itis.ethz.ch

 

IT'IS Foundation Appointed as Member Organization of SATW

At the 30th General Assembly of the Swiss Academy of Engineering Sciences (SATW) in Zurich on April 7, 2011, the IT'IS Foundation was appointed as a full member organization

 
PUBLICATIONS

17/03/2011

Contact
nk@itis.ethz.ch

 

Estimation of Head Tissue-Specific Exposure from Mobile Phones Based on Measurements in the Homogeneous SAM Head

Marie-Christine Gosselin, Sven Kühn, Pedro Crespo-Valero, Emilio Cherubini, Marcel Zefferer, Andreas Christ, and Niels Kuster, Bioelectromagnetics, Volume 32, Issue 6, pages 493–505, September 2011, online March 17

 
Other News

16/03/2011

Contact
irissz@itis.ethz.ch

 

Updated Program Available for the International Workshop on RF Hotspots & Thermal Hazards

MRI+ invites to the 'Thermal Workshop on RF Hotspots' with international experts and FDA to discuss RF safety of MR scanners and develop concepts for future safety guidelines. Updated program available here.

 

 
PUBLICATIONS

02/03/2011

Contact
nk@itis.ethz.ch

 

Manycore Stencil Computations in Hyperthermia Applications

Matthias Christen, Olaf Schenk, Esra Neufeld, Maarten Paulides, and Helmar Burkhart, “Manycore Stencil Computations in Hyperthermia Applications,” in “Scientific Computing with Multicore and Accelerators,” Jakub Kurzak, David A. Bader, and Jack Dongarra, Eds., CRC Press, Taylor & Francis Group, Boca Raton, FL, USA, 2011

 
AWARDS

24/02/2011

Contact
nk@itis.ethz.ch

 

Marie-Christine Gosselin Wins Best Student Platform Presentation at EBEA 2011

The award for the best scientific platform presentation by a student at the 10th International Conference of the European Bioelectromagnetic Association (EBEA 2011) went to Marie-Christine Gosselin

 
PRESS

23/02/2011

Contact
nk@itis.ethz.ch

 

NIH Study on "Effects of Cell Phone Radiofrequency Signal Exposure on Brain Glucose Metabolism" Received World-Wide Media Coverage

Nora D. Volkow, Dardo Tomasi, Gene-Jack Wang, Paul Vaska, Joanna S. Fowler, Frank Telang, Dave Alexoff, Jean Logan, Christopher Wong, in JAMA 2011, Volume 305, Issue 8, pp. 808–813

In a preliminary communication in the February 23rd issue of the Journal of the American Medical Association (JAMA), Nora Volkow and colleagues report on the effects of mobile phone radiofrequency (RF) signal exposure on brain glucose metabolism.

 
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