NEWS
01/06/2017
PUBLICATIONS

Noninvasive Deep Brain Stimulation via Temporally Interfering Electric Fields

Nir Grossman, David Bono, Nina Dedic, Suhasa B. Kodandaramaiah, Andrii Rudenko, Ho-Jun Suk, Antonino M. Cassara, Esra Neufeld, Niels Kuster, Li-Huei Tsai, Alvaro Pascual-Leone, and Edward S. Boyden, CellVolume 169, Issue 6, pp. 1029–1041, online 1 June 2017, doi: 10.1016/j.cell.2017.05.024

The paper reports a noninvasive strategy for electrically stimulating neurons at depth. By delivering to the brain multiple electric fields at frequencies too high to recruit neural firing, but which differ by a frequency within the dynamic range of neural firing, it is possible to electrically stimulate neurons throughout a region where interference between the multiple fields results in a prominent electric field envelope modulated at the difference frequency. This temporal interference (TI) concept was validated via modeling and physics experiments, and it was verified that neurons in the living mouse brain could follow the electric field envelope. The utility of TI stimulation is demonstrated by stimulating neurons in the hippocampus of living mice without recruiting neurons of the overlying cortex. Finally, it is shown that by altering the currents delivered to a set of immobile electrodes, different motor patterns can be steerably evoked in living mice.

The scientific and technical impact of the study can be summarized as:

  • A new, noninvasive technique to stimulate deep brain structures has been developed and tested by using computational modeling and phantom measurements, as well as electrophysiological measurements in vivo;
  • TI stimulation sends interfering, low-frequency modulated, high frequency signals from multiple pairs of electrodes placed on the scalp through the brain, avoiding stimulation of other areas;
  • The results make TI stimulation a promising alternative to surgical electrical stimulation interventions such as deep brain stimulation (DBS) for e.g., Parkinson's disease patients.
Page 9 of 17
PUBLICATIONS

21/03/2010

Contact
nk@itis.ethz.ch

 

Swiss government commissioned study: “Assessment of EM Exposure of Energy-Saving Bulbs & Possible Mitigation Strategies”

Project BAG/08.004316/434.0001/-13 & BFE/15350
Jagadish Nadakuduti, Mark Douglas, Myles Capstick, Sven Kühn, Stefan Benkler, and Niels Kuster, March 2010

 
PUBLICATIONS

08/03/2010

Contact
oberle@itis.ethz.ch

 

Signal Transmission by Galvanic Coupling Through the Human Body

Marc Simon Wegmueller, Michael Oberle, Norbert Felber, Niels Kuster, and Wolfgang Fichtner, in IEEE Transactions on Instrumentation and Measurement, Volume 59, Issue 4, pp. 963–969, 8 March 2010, online October 6, 2009

 
PUBLICATIONS

01/03/2010

Contact
dominik@itis.ethz.ch

 

Simulation of Oscillatory Flow in an Aortic Bifurcation Using FVM and FEM: a Comparative Study of Implementation Strategies

Trushar Gohil, Robert McGregor, Dominik Szczerba, Kathrin Burckhardt, Krishnamurthy Muralidhar, and Gábor Székely, in International Journal for Numerical Methods in Fluids, Volume 66, Issue 8, pp. 1037–1067, 20 July 2011, online ahead of print, 1 March 2010

 
PUBLICATIONS

31/01/2010

Contact
dominik@itis.ethz.ch

 

Efficient Generation of Corresponding Meshes for Biomedical Flow Simulations

Robert H. P. McGregor, Bryn A. Lloyd, Dominik Szczerba, Gabor Székely, in Lecture Notes in Computer Science – International Symposium on Biomedical Simulation - ISBMS 2010, Volume 5958/2010, pp. 49–58, January 2010

 
PUBLICATIONS

05/01/2010

Contact
nk@itis.ethz.ch

 

DNA Fragmentation in Human Fibroblasts under Extremely Low Frequency Electromagnetic Field Exposure

Frauke Focke, David Schuermann, Niels Kuster, Primo Schär, in Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, Volume 683, Issues 1-2, pp. 74–83, 5 January 2010, online 6 November

 
VIRTUAL POPULATION

01/01/2010

Contact
nk@itis.ethz.ch

 

Virtual Classroom

The IT'IS Foundation releases the Virtual Classroom for scientific purposes. The models were partially funded by the BfS, Germany, and extends the Virtual Family models.

 

 
PUBLICATIONS

21/12/2009

Contact
dominik@itis.ethz.ch

 

A Computational Model of Intussusceptive Microvascular Growth and Remodeling

Dominik Szczerba, Haymo Kurz, and Gabor Szekely, in Journal of Theoretical Biology, Volume 261, Issue 4, pp. 570–583, 21 December 2009, online 17 September

 

 
Other News

01/12/2009

Contact
oberle@itis.ethz.ch

 

Techniques to Demonstrate MRI Safety of Medical Implants

Michael Oberle, in Microwave Journal, Volume 52, Issue 12, pp.60-7, December 2009

 

 
PUBLICATIONS

26/10/2009

Contact
nk@itis.ethz.ch

 

Proteomic Analysis of the Response of Human Endothelial Cell Line EA.hy926 to 1800 GSM Mobile Phone Radiation

Reetta Nylund, Hanna Tammio, Niels Kuster, and Dariusz Leszczynski, in Journal of Proteomics & Bioinformatics, Volume 2, Issue 10, pp. 455–462, October 2009, online 26 October

 

 
PRESS

12/10/2009

Contact
capstick@itis.ethz.ch

 

EU Workshop in Umeå, Sweden: Occupational Exposure to EMF: Paving the Way for a Future EU Initiative

Information link to do with the EU organized workshop regarding occupational exposure to EMF.

 
PUBLICATIONS

09/10/2009

Contact
douglas@itis.ethz.ch

 

Guidelines for the Evaluation of Exposure from Wireless Power Transmission Systems

Mark G. Douglas, Andreas Christ, and Niels Kuster, short paper, IT'IS Foundation, Zeughausstrasse 43, 8004 Zurich, Switzerland, October 2009

 

 
PUBLICATIONS

01/10/2009

Contact
dominik@itis.ethz.ch

 

A Fast Alternative to Computational Fluid Dynamics for High Quality Imaging of Blood Flow

Robert H. P. McGregor, Dominik Szczerba, Krishnamurthy Muralidhar and Gábor Székely, in Lecture Notes in Computer Science: Medical Image Computing and Computer-Assisted Intervention – MICCAI 2009, Volume 5704/200, pp. 124–131, October 1, 2009

 

 
Other News

29/09/2009

Contact
nk@itis.ethz.ch

 

IT'IS: Two New PhD Defenses

Sven Kuehn and Sven Ebert successfully defended their theses at the Swiss Federal Institute of Technology, Zurich (ETHZ)

 
PUBLICATIONS

21/09/2009

Contact
kuehn@itis.ethz.ch

 

Assessment of the Radio-Frequency Electromagnetic Fields Induced in the Human Body from Mobile Phones used with Hands-free Kits

Sven Kuhn, Eugenia Cabot, Andreas Christ, Myles Capstick and Niels Kuster, in Physics in Medicine and Biology, Volume 54, Number 18, pp. 5493–5508, 21 September 2009, online 26 August

 

 
PUBLICATIONS

15/09/2009

Contact
chavanne@itis.ethz.ch

 

Effects of Hand Phantom on Mobile Phone Antenna Performance

Chung-Huan Li, Erdem Ofli, Nicolas Chavannes, and Niels Kuster, in IEEE Transactions on Antenna and Propagation, Volume 57, Issue 9, pp. 2763–2770, September 2009

 

 
PRESS

14/09/2009

Contact
nk@itis.ethz.ch

 

US Senate Hearing on the Health Effects of Cell Phone Use

US Senate hearing on health effects of cell phone use.

 

 
PUBLICATIONS

09/09/2009

Contact
nk@itis.ethz.ch

 

Ebert (2009) Thesis

Sven Ebert, “EMF Risk Assessment: Exposure Systems for Large-Scale Laboratory and Experimental Provocation Studies,” PhD Thesis, Swiss Federal Insititute of Technology, Thesis No. 18636, Zurich, 2009

 
PUBLICATIONS

09/09/2009

Contact
nk@itis.ethz.ch

 

Kühn (2009) Thesis

Sven Kühn, “EMF Risk Assessment: Exposure Assessment and Compliance Testing in Complex Environments,” PhD Thesis, Swiss Federal Insititute of Technology, Thesis No. 18637, Zurich, 2009

 
PUBLICATIONS

22/08/2009

Contact
dominik@itis.ethz.ch

 

Fast Implicit Simulation of Oscillatory Flow in Human Abdominal Bifurcation using a Schur Complement Preconditioner

Kathrin Burckhardt, Dominik Szczerba, Jedediah Brown, Krishnamurthy Muralidhar, and Gabor Szekely, in Lecture Notes in Computer Science: Euro-Par 2009 - Parallel Processing (refereed proceedings of the 15th International Euro-Par Conference, Delft, The Netherlands, August 25-28, 2009),Volume 5704/200, pp. 747–759, August 22, 2009

 
PUBLICATIONS

10/08/2009

Contact
dominik@itis.ethz.ch

 

A Multiphysics Model of Myoma Growth

Dominik Szczerba, Bryn A. Lloyd, Michael Bajka, and Gabor Szekely, in International Journal for Multiscale Computational Engineering, Volume 7, Issue 1, pp. 17–27, August 2009

 

 
PUBLICATIONS

03/08/2009

Contact
oberle@itis.ethz.ch

 

Galvanic Coupling Enabling Wireless Implant Communications

Marc Simon Wegmueller, Sonja Huclova, Juerg Froehlich, Michael Oberle, Norbert Felber, Niels Kuster, Wolfgang Fichtner, in IEEE Transactions on Instrumentation and Measurement, Volume 58, Issue 8, pp. 2618–2625, August 2009, online July 7

 

 
Other News

01/08/2009

Contact
nk@itis.ethz.ch

 

Excerpt of FDA Activity Report to US Congress

A new IT'IS Project:

Critical Path:  Biomarker Development for Evaluation of Device Interventions After Heart Failure

 
PUBLICATIONS

07/07/2009

Contact
neufeld@itis.ethz.ch

 

Measurement, Simulation and Uncertainty Assessment of Implant Heating During MRI

Esra Neufeld, Sven Kühn, Gabor Szekely and Niels Kuster, in Physics in Medicine and Biology, Volume 54, Issue 13, pp. 4151–4169, July 2009

 

 
PUBLICATIONS

07/07/2009

Contact
neufeld@itis.ethz.ch

 

Parallel Scalable PDE-Constrained Optimization: Antenna Identification in Hyperthermia Cancer Treatment Planning

Olaf Schenk, Murat Manguoglu, Ahmed Sameh, Matthias Christen and Madan Sathe, in Computer Science - Research and Development: ISC09, Volume 23, Issue 3-4, pp. 177–183, June 2009

 

 
Other News

01/07/2009

Contact
chavanne@itis.ethz.ch

 

Effective Full 3D EMI Analysis of Complex PCBs by Utlilizing the Latest Advances in Numerical Methods Combined with Novel Time-domain Measurement Technologies

Chung-Huan Li, Peter Futter, Nicolas Chavannes, and Niels Kuster, Microwave Engineering Europe, July/August 2009

 

 
PUBLICATIONS

30/06/2009

Contact
kuehn@itis.ethz.ch

 

MMF/GSMA commissioned study: “Scientific Basis for Base Station Exposure Compliance Standards”

Project MMF/GSMA Phase 2, Workpackages 6 & 7:
Sven Kühn et al, June 2009

 
ANNUAL REPORTS

20/06/2009

Contact
nk@itis.ethz.ch

 

IT'IS Annual Report 2008

The Annual Report 2008 features key figures for 2008 and overviews of selected projects:

  • Novel Low Frequency Solvers
  • Methods & Procedures for Safety Assessments/Optimization of MRI
  • In Silico Tumor Modeling
  • Populating Computational Space

 
AWARDS

19/06/2009

 

IT'IS Wins Five Student Awards at BioEM2009 Meeting in Davos, Switzerland, June 15–19, 2009

IT'IS PhD students Manuel Murbach, Sven Kühn, and Marie-Christine Gosselin wins a total of five student awards at the 2009 Joint Meeting of The Bioelectromagnetics Society and the European BioElectromagnetics Associations (BioEM2009) in Davos, Switzerland

 
MAJOR EVENTS

14/06/2009

Contact
nk@itis.ethz.ch

 

2009 Joint Meeting of The Bioelectromagnetics Society and the European BioElectromagnetics Association

The IT'IS Foundation was the local organizer for the triennial joint meeting of the two bioelectromagnetics societies that occured in Davos, Switzerland in the summer of 2009.

 
PUBLICATIONS

28/05/2009

Contact
dominik@itis.ethz.ch

 

A Mechano-Chemical Model of a Solid Tumor for Therapy Outcome Predictions

Sven Hirsch, Dominik Szczerba, Bryn Lloyd, Michael Bajka, Niels Kuster, and Gábor Székely, in Lecture Notes in Computer Science: Computational Science – ICCS 2009 (Proceedings, Part I, of the 9th International Conference of Computational Science, Baton Rouge, LA, USA, May 25-27, 2009), Volume 5544/2009, pp. 715–724, May 20, 2009

 

 
Page 9 of 17
 
first page previous page 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 ALL next page last page
 
CONTACT INFORMATION
 
+41 44 245 96 96