NEWS
01/06/2017
PUBLICATIONS

Noninvasive Deep Brain Stimulation via Temporally Interfering Electric Fields

Nir Grossman, David Bono, Nina Dedic, Suhasa B. Kodandaramaiah, Andrii Rudenko, Ho-Jun Suk, Antonino M. Cassara, Esra Neufeld, Niels Kuster, Li-Huei Tsai, Alvaro Pascual-Leone, and Edward S. Boyden, CellVolume 169, Issue 6, pp. 1029–1041, online 1 June 2017, doi: 10.1016/j.cell.2017.05.024

The paper reports a noninvasive strategy for electrically stimulating neurons at depth. By delivering to the brain multiple electric fields at frequencies too high to recruit neural firing, but which differ by a frequency within the dynamic range of neural firing, it is possible to electrically stimulate neurons throughout a region where interference between the multiple fields results in a prominent electric field envelope modulated at the difference frequency. This temporal interference (TI) concept was validated via modeling and physics experiments, and it was verified that neurons in the living mouse brain could follow the electric field envelope. The utility of TI stimulation is demonstrated by stimulating neurons in the hippocampus of living mice without recruiting neurons of the overlying cortex. Finally, it is shown that by altering the currents delivered to a set of immobile electrodes, different motor patterns can be steerably evoked in living mice.

The scientific and technical impact of the study can be summarized as:

  • A new, noninvasive technique to stimulate deep brain structures has been developed and tested by using computational modeling and phantom measurements, as well as electrophysiological measurements in vivo;
  • TI stimulation sends interfering, low-frequency modulated, high frequency signals from multiple pairs of electrodes placed on the scalp through the brain, avoiding stimulation of other areas;
  • The results make TI stimulation a promising alternative to surgical electrical stimulation interventions such as deep brain stimulation (DBS) for e.g., Parkinson's disease patients.
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PUBLICATIONS

15/05/2009

Contact
gosselin@itis.ethz.ch

 

Dependence of the Occupational Exposure to Mobile Phone Base Stations on the Properties of the Antenna and the Human Body

Marie-Christine Gosselin, Andreas Christ, Sven Kühn, and Niels Kuster, in IEEE Transactions on Electromagnetic Compatibility, Volume 51, Issue 2, pp. 227–235, May 2009

 

 
PUBLICATIONS

15/05/2009

Contact
nk@itis.ethz.ch

 

Absence of Genotoxic Potential of 902 MHz (GSM) and 1747 MHz (DCS) Wireless Communication Signals: In vivo Two-year Bioassay in B6C3F1 Mice

Christina Ziemann, Heidrun Brockmeyer, Siddharth B. Reddy, Vijayalaxmi, Thomas J. Prihoda, Niels Kuster, Thomas Tillmann and Clemens Dasenbrock, in International Journal of Radiation Biology, Volume 85, Issue 5, pp. 454–464, May 2009

 

 
PUBLICATIONS

15/05/2009

Contact
douglas@itis.ethz.ch

 

An Algorithm for Predicting the Change in SAR in a Human Phantom due to Deviations in its Complex Permittivity

Mark G. Douglas, Michael Y. Kanda, Wilson G. Luengas, Maurice Ballen, Tadeusz M. Babij, and Chung-Kwang Chou,  IEEE Transactions on Electromagnetic Compatibility, Volume 51, Issue 2, pp. 570–583, May 2009

 

 
PUBLICATIONS

14/04/2009

Contact
nk@itis.ethz.ch

 

Amplitude-modulated Electromagnetic Fields for the Treatment of Cancer: Discovery of Tumor-specific Frequencies and Assessment of a Novel Therapeutic Approach

Alexandre Barbault, Frederico P. Costa, Brad Bottger, Reginald F. Munden, Fin Bomholt, Niels Kuster, and Boris Pasche, in Journal of Experimental & Clinical Cancer Research, Volume 28, Issue 1, p51, April 2009

 

 
PRESS

23/03/2009

Contact
nk@itis.ethz.ch

 

Discussion on new technologies in KABA magazine

January 2009, Professor Niels Kuster, Director of the IT'IS Foundation participated in a discussion on current new technologies with Ulrich Wydler, Head of Access + Data Systems EMEA at the KABA group.

 
PUBLICATIONS

01/03/2009

Contact
capstick@itis.ethz.ch

 

A Novel Indirect Method to Determine the Radiation Impedance of a Handheld Antenna Structure

Myles H. Capstick, Jari O. Jekkonen, Andrew C. Marvin, Ian D. Flintoft, and Linda Dawson, in IEEE Transactions on Instrumentation and Measurement, Volume 58, Issue 3, pp. 578–585, March 2009

 

 
PUBLICATIONS

01/02/2009

Contact
kuehn@itis.ethz.ch

 

Assessment of Induced Radio-frequency Electromagnetic Fields in Various Anatomical Human Body Models

Sven Kühn, Wayne Jennings, Andreas Christ and Niels Kuster, Physics in Medicine and Biology, Volume 54, Issue 4, pp. 875–890, January 2009

 

 
PUBLICATIONS

15/01/2009

Contact
nk@itis.ethz.ch

 

Mobile Phone Exposure and Spatial Memory

Clairy Wiholm, Arne Lowden, Niels Kuster, Lena Hillert, Bengt B. Arnetz, Torbjörn Åkerstedt, and Scott D. Moffat, in Bioelectromagnetics, Volume 30, Issue 1, pp. 59–65, January 2009

 

 
PUBLICATIONS

05/01/2009

Contact
nk@itis.ethz.ch

 

Exploring Exposure to Mobile Phone Electromagnetic Fields and Psychophysiological and Self-rated Symptoms

Bengt B. Arnetz, Clairy Wiholm, Niels Kuster, Lena Hillert, and Scott D. Moffat, Psychosomatic Medicine, Volume 71, Issue 1, pp. 115. January 2009

 

 
PUBLICATIONS

30/12/2008

Contact
nk@itis.ethz.ch

 

An Investigation into Occupational Exposure to Electromagnetic Fields for Personnel Working With and Around Medical Magnetic Resonance Imaging Equipment

Myles Capstick, Donald McRobbie, Jeff Hand, Andreas Christ, Sven Kühn, Kjell Hansson Mild, Eugenia Cabot, Yan Li, Amir Melzer, Annie Papadak, Klaas Prüssmann, Rebecca Quest, Marc Rea, Salome Ryf, Michael Oberle, and Niels Kuster, EU COMMISSION Study on MRI (Project VT/2007/017), IT'IS Foundation & Imperial College, London

 

 
PUBLICATIONS

01/12/2008

Contact
nk@itis.ethz.ch

 

 
PUBLICATIONS

18/11/2008

 

On the Coupling Integrals Arising in the Method of Moments Formulation of Laterally Bounded Structures

Pedro Crespo-Valero, Ivica Stevanovic, Daniel Llorens del Rio, Juan R Mosig, IEEE Transactions on Microwave Theory and Techniques, Volume 56, Issue 12, Part 1, pp. 2885–2892, November 2008

 

 
Other News

16/10/2008

Contact
nk@itis.ethz.ch

 

BioEM 2009 Website Launched

A new website for the 2009 Bioelectromagnetics conference has been launched

 
PUBLICATIONS

15/10/2008

Contact
dominik@itis.ethz.ch

 

Exploring the Use of Proper Orthogonal Decomposition for Enhancing Blood Flow Images Via Computational Fluid Dynamics

Robert McGregor, Dominik Szczerba, Martin von Siebenthal, Krishnamurthy Muralidhar, and Gábor Székely, Lecture Notes in Computer Science: Medical Image Computing and Computer-Assisted Intervention 5242/2008, pp. 782–789, October 2008

 

 
PUBLICATIONS

01/10/2008

Contact
dominik@itis.ethz.ch

 

Modeling Intravasation of Liquid Distension Media in Surgical Simulators

Stefan Tuchschmid, Michael Bajka, Dominik Szczerba, Bryn A. Lloyd, Gabor Székely, and Matthias Harders, Medical Image Analysis, Volume 12, Issue 5, pp. 567–576, October 2008

 

 
PUBLICATIONS

01/09/2008

Contact
dominik@itis.ethz.ch

 

A Computational Framework for Modelling Solid Tumour Growth

Bryn A. Lloyd, Dominik Szczerba, Markus Rudin and Gábor Székely, Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, Volume 366, Issue 1879, pp. 3301–3318, September 2008

 

 
PUBLICATIONS

01/09/2008

Contact
nk@itis.ethz.ch

 

The Expression of PHOX2A, PHOX2B and of Their Target Gene dopamine-β-hydroxylase (DβH) is Not Modified by Exposure to Extremely-Low-Frequency Electromagnetic Field (ELF-EMF) in a Human Neuronal Model

Roberta Benfante, Ruth Adele Antonini, Niels Kuster, Juergen Schuderer, Christian Maercker, Franz Adlkofer, Francesco Clementi and Diego Fornasari, in Toxicology in Vitro, Volume 22, Issue 6, pp. 1489–1495, September 2008

 
Other News

28/08/2008

Contact
nk@itis.ethz.ch

 

IT'IS: Two New PhD Defenses

Esra Neufeld and Stefan Schild successfully defended their theses at the Swiss Federal Institute of Technology, Zurich (ETHZ)

 
PUBLICATIONS

01/08/2008

 

Effective EM Simulations with Micro-λ Resolution in Macro-λ Objects – Generalized Huygens Box Method

Nicolas Chavannes et al, Microwave Engineering Europe, July/August 2008

 

 
PUBLICATIONS

15/07/2008

Contact
dominik@itis.ethz.ch

 

Mechanism and Localization of Wall Failure During Abdominal Aortic Aneurysm Formation

Dominik Szczerba, Robert McGregor, Krishnamurthy Muralidhar, and Gábor Székely, Lecture Notes in Computer Science: Biomedical Simulation 5104/2008, pp. 119–126, July 2008

 

 
Other News

01/07/2008

Contact
chavanne@itis.ethz.ch

 

 
AWARDS

12/06/2008

 

BEMS 2008 Student Award

IT'IS PhD student Sven Kühn wins a student award at the 2008 meeting of the Bioelectromagnetics Society (BEMS2008), in San Diego, California, USA

 
Other News

11/06/2008

Contact
nk@itis.ethz.ch

 

Niels Kuster Appointed President of BEMS

IT'IS Foundation Director Prof. Niels Kuster began his term as President of the Bioelectromagnetics Society.

 
Other News

03/06/2008

 

Tumor Promotion by Chronic UMTS-Modulated Radiofrequency Exposure in Mice Prenatally Treated with ENU

Thomas Tillmann, Heinrich Ernst, Tina Reinhardt, Andreas Bitz, Joachim Streckert, Volkert Hansen, Ulrich Mohr and Clemens Dasenbrock, in Abstract Booklet, IMBA-FGF-Workshop/Omics for Assessing Unclear Risks, Berlin, Germany, May 26–28, 2008

 
Other News

24/05/2008

Contact
nk@itis.ethz.ch

 

Studies of Prof. Hugo Rüdiger's Group at the University of Vienna Were Not Blinded; Urged the Group to Withdraw the Papers

The RF studies of Prof. Hugo Rüdiger's group at the University of Vienna were apparently not blinded and therefore the University urged the group to withdraw its papers

 
VIRTUAL POPULATION

19/05/2008

Contact
nk@itis.ethz.ch

 

Enhanced Virtual Family Models: Ella, Duke, Billie, Thelonious

The enhanced models from the Virtual Family Project with unprecedented anatomical detail and accuracy are now available to the scientific community through the IT'IS Foundation.

 

 
ANNUAL REPORTS

30/04/2008

Contact
nk@itis.ethz.ch

 

IT'IS Annual Report 2007

The Annual Report 2007 features key figures for 2007 and overviews of selected projects:

  • Full-Wave Spice Based EM-Circuit Co-Simulator in Time Domain
  • Engineering and Medicine Meets Virtual Reality
  • EM Cancer Diagnostics and Therapeutics
  • NIEHS/NTP – RF Radiation Research Program In Vivo Exposure Facility

 
PUBLICATIONS

15/04/2008

Contact
chavanne@itis.ethz.ch

 

Mastering Conformal Meshing for Complex CAD-Based C-FDTD Simulations

Stefan Benkler, Nicolas Chavannes and Niels Kuster, in IEEE Antennas and Propagation Magazine, Volume 50, Issue 2, pp. 45–57, April 2008

 
PUBLICATIONS

15/04/2008

Contact
nk@itis.ethz.ch

 

The Effects of 884 MHz GSM Wireless Communication Signals on Headache and Other Symptoms: An Experimental Provocation Study

Lena Hillert, Torbjörn Åkerstedt, Arne Lowden, Clairy Wiholm, Niels Kuster, Sven Ebert, Clementine Boutry, Scott Douglas Moffat, Mats Berg, and Bengt Birger Arnetz, in Bioelectromagnetics, Volume 29, Issue 3, pp. 185–196, April 2008

 

 
PUBLICATIONS

04/04/2008

Contact
nk@itis.ethz.ch

 

Neufeld (2008) Thesis

Esra Neufeld, “High Resolution Hyperthermia Treatment Planning,” PhD Thesis, Swiss Federal Insititute of Technology, Thesis No. 17947, Zurich, 2008

 
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