NEWS
01/06/2017
PUBLICATIONS

Noninvasive Deep Brain Stimulation via Temporally Interfering Electric Fields

Nir Grossman, David Bono, Nina Dedic, Suhasa B. Kodandaramaiah, Andrii Rudenko, Ho-Jun Suk, Antonino M. Cassara, Esra Neufeld, Niels Kuster, Li-Huei Tsai, Alvaro Pascual-Leone, and Edward S. Boyden, CellVolume 169, Issue 6, pp. 1029–1041, online 1 June 2017, doi: 10.1016/j.cell.2017.05.024

The paper reports a noninvasive strategy for electrically stimulating neurons at depth. By delivering to the brain multiple electric fields at frequencies too high to recruit neural firing, but which differ by a frequency within the dynamic range of neural firing, it is possible to electrically stimulate neurons throughout a region where interference between the multiple fields results in a prominent electric field envelope modulated at the difference frequency. This temporal interference (TI) concept was validated via modeling and physics experiments, and it was verified that neurons in the living mouse brain could follow the electric field envelope. The utility of TI stimulation is demonstrated by stimulating neurons in the hippocampus of living mice without recruiting neurons of the overlying cortex. Finally, it is shown that by altering the currents delivered to a set of immobile electrodes, different motor patterns can be steerably evoked in living mice.

The scientific and technical impact of the study can be summarized as:

  • A new, noninvasive technique to stimulate deep brain structures has been developed and tested by using computational modeling and phantom measurements, as well as electrophysiological measurements in vivo;
  • TI stimulation sends interfering, low-frequency modulated, high frequency signals from multiple pairs of electrodes placed on the scalp through the brain, avoiding stimulation of other areas;
  • The results make TI stimulation a promising alternative to surgical electrical stimulation interventions such as deep brain stimulation (DBS) for e.g., Parkinson's disease patients.
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PUBLICATIONS

15/08/2016

Contact
nk@itis.ethz.ch

 

Parallel smoothing pressure correction solver for biomedical flow problems: convergence criteria, preconditioning, scalability

Kathrin Burckhardt, Dominik Szczerba, Esra Neufeld, Krishnamurthy Muralidhar, and Niels Kuster, Progress in Computational Fluid Dynamics, Volume 16, Issue 4, pp. 201–215, online August 10, 2016

 
VIRTUAL POPULATION

13/07/2016

Contact
vip@itis.ethz.ch

 

Release of New Posable Virtual Population Models V3.1!

IT’IS proudly announces the release of the full range of ViP models, now upgraded for use with the new Poser method available in the multiphysics computational life sciences platform Sim4Life 2.2!

 

 
Other News

30/06/2016

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nk@itis.etzh.ch

 

Latsis Symposium 2016 ETH Zurich on Personalized Medicine, June 27–29, 2016

The IT'IS Foundation joined forces with the Competence Center Personalized Medicine UZH/ETH to host the Latsis Symposium 2016 on Personalized Medicine at the ETH Zurich, June 27 – 29, 2016. More than 250 attendees assembled to explore a wide range of topics on research and policy in precision medicine with leading experts from clinics, universities, regulatory agencies, and industry. The event closed with a well-attended German-language public event on Wednesday evening, June 29.

 
Other News

10/06/2016

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nk@itis.ethz.ch

 

NIEHS Press Release on NTP Study of Cell Phone RF Radiation and Carcinogensis in Rats

The National Toxicology Program (NTP) of NIEHS released a report entitled, “Report of Partial Findings From the National Toxicology Program Carcinogenesis Studies of Cell Phone Radiofrequency Radiation in Hsd: Sprague Dawley SD Rats (Whole Body Exposure).” This was a joint study with the IT'IS Foundation.

 
PUBLICATIONS

07/06/2016

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nk@itis.ethz.ch

 

Investigation of assumptions underlying current safety guidelines on EM-induced nerve stimulation

Esra Neufeld, Ioannis Vogiatzis Oikonomidis, Maria Ida Iacono, Leonardo M. Angelone, Wolfgang Kainz, and Niels Kuster, Physics in Medicine and Biology, Volume 61, Issue 12, pp. 4466–4478, online May 2016

 
PUBLICATIONS

07/06/2016

Contact
nk@itis.ethz.ch

 

Functionalized anatomical models for EM-neuron interaction modeling

Esra Neufeld, Antonino M. Cassara, Hazael Montanaro, and Niels Kuster, Physics in Medicine and Biology, Volume 61, Issue 12, 4390–4401, online May 25, 2016

 
AWARDS

23/05/2016

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nk@itis.ethz.ch

 

IT’IS Wins Award for Best Poster in Session at the 2016 Annual Meeting of the International Society for Magnetic Resonance in Medicine

The IT'IS Foundation won the best poster award in a joint session on High Field Systems & Applications and MR Safety at the 24th Annual Meeting of the International Society for Magnetic Resonance in Medicine (ISMRM) in Singapore, 7 – 13 May 2016. Earl Zastrow presented the poster entitled "Development of a Set of Generic Numerical Birdcages for Comprehensive Evaluations of Induced RF Fields for Implant Safety."

 
PUBLICATIONS

18/05/2016

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nk@itis.ethz.ch

 

Comparative dosimetry for children and rodents exposed to extremely low-frequency magnetic fields

Yijian Gong, Myles Capstick, Clemens Dasenbrock, Maren Fedrowitz, Cesar Cobaleda, Isidro Sanchez-Garcia, and Niels Kuster, Bioelectromagnetics, Volume 37, Issue 5, pp. 310–322, July 2016, online May 13, 2016

 
PUBLICATIONS

17/05/2016

Contact
nk@itis.ethz.ch

 

Pregnant women models analyzed for RF exposure and temperature increase in 3T RF shimmed birdcages

Manuel Murbach, Esra Neufeld, Theodoros Samaras, Juan Córcoles, Fraser J. Robb, Wolfgang Kainz, and Niels Kuster, Magnetic Resonance in Medicine, Early View, May 2016, online May 17, 2016

 
PUBLICATIONS

13/05/2016

Contact
nk@itis.ethz.ch

 

Dielectric Resonator Reflectarray as High-Efficiency Nonuniform Terahertz Metasurface

Daniel Headland, Eduardo Carrasco, Shruti Nirantar, Withawat Withayachumnankul, Philipp Gutruf, James Schwarz, Derek Abbott, Madhu Bhaskaran, Sharath Sriram, Julien Perruisseau-Carrier, and Christophe Fumeaux, ACS Photonics, online May 13, 2016, DOI: 10.1021/acsphotonics.6b00102

 
PUBLICATIONS

01/04/2016

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nk@itis.ethz.ch

 

An HF exposure system for mice with improved efficiency

Myles Capstick, Yijian Gong, Boris Pasche, and Niels Kuster, Bioelectromagnetics, Volume 37, Issue 4, pp. 223–233, May 2016, online March 31, 2016

 
PUBLICATIONS

17/03/2016

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nk@itis.ethz.ch

 

Extremely low-frequency magnetic fields and the risk of childhood leukemia: A risk assessment by the ARIMMORA consortium

Joachim Schüz, Clemens Dasenbrock, Paolo Ravazzani, Martin Röösli, Primo Schär, Patricia L. Bounds, Friederike Erdmann, Arndt Borkhardt, César Cobaleda, Maren Fedrowitz, Yngve Hamnerius, Isidro Sanchez-Garcia, Rony Seger, Kjeld Schmiegelow, Gunde Ziegelberger, Myles Capstick, Melissa Manser, Meike Müller, Christoph D. Schmid, David Schürmann, Benjamin Struchen, and Niels Kuster, Bioelectromagnetics, Volume 37, Issue 3, pp. 183–189, April 2016, online March 15, 2016

 
Other News

11/03/2016

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nk@itis.etzh.ch

 

IT’IS Foundation Research on Validation of Fast SAR Solutions Featured at MIC MRA Workshop in Tokyo

Prof. Niels Kuster presented the current status of the IT’IS Foundation’s effort to develop comprehensive validation concepts for vector probe systems and their implementation at the MIC MRA International Workshop hosted by the Japanese Ministry of Internal Affairs and Communications (MIC) March 2 – 3, 2016 in the U Thant International Conference Hall of Tokyo’s United Nations University.

 
Other News

04/02/2016

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nk@itis.etzh.ch

 

IT'IS/Speag/ZMT Retreat in Melchsee-Frutt on Mastering Sales/Funding, Spotting Trends and Shaping the Future

Twenty IT'IS, SPEAG, and ZMT co-workers convened for two-day retreat, 01 – 02 February 2016, held at the Hotel Frutt Lodge & SPA, in Melchsee-Frutt, Canton Obwalden. The goal of the retreat was to learn how to spot trends and become a trend setter, to master sales, to assess the current status of the organization, and to establish measures for improvement.

 
Other News

02/02/2016

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nk@itis.etzh.ch

 

Sim4Life Featured in the Nano World Cancer Day 2016

Esra Neufeld represented the IT'IS Foundation in this successful event, with a presentation and an interactive demonstration of Sim4Life, which was very well received as a promising tool for the care of cancer patients.

 
Other News

22/01/2016

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nk@itis.etzh.ch

 

Let’s Party! Festivities to Kick Start 2016!

This year’s party of Z43 (IT'IS Foundation, SPEAG, ZMT) was held at trendy Art Dock, located in the former freight terminal between Zurich’s Hardbrücke and Central train stations.

 
PUBLICATIONS

18/01/2016

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nk@itis.ethz.ch

 

Desktop exposure system and dosimetry for small scale in vivo radiofrequency exposure experiments

Yijian Gong, Myles Capstick, Thomas Tillmann, Clemens Dasenbrock, Theodoros Samaras, and Niels Kuster, Bioelectromagnetics, Volume 37, Issue 1, pp. 49–61, January 2016, online December 18, 2015

 
Other News

13/01/2016

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nk@itis.etzh.ch

 

Avicenna Roadmap on In Silico Clinical Trials Published

The research and technological development roadmap in support of in silico clinical trials produced by the Avicenna Action is now published online, click here to go to Research Gate for a download link. Davnah Payne represented the IT’IS Foundation as one of 525 experts in this initiative funded by the European Commission. 

 
PUBLICATIONS

17/12/2015

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nk@itis.ethz.ch

 

Novel Exposure Units for at-Home Personalized Testing of Electromagnetic Sensibility

Anke Huss, Manuel Murbach, Imke van Moorselaar, Niels Kuster, Rob van Strien, Hans Kromhout, Roel Vermeulen, and Pauline Slottje, Bioelectromagnetics, Volume 37, Issue 1, pp. 62–68, January 2016, online December 11, 2015

 
Other News

14/12/2015

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nk@itis.etzh.ch

 

Special Section on ESHO2015 in the International Journal of Hyperthermia

The 30th annual meeting of the European Society for Hyperthermic Oncology (ESHO 2015) hosted by IT'IS/ETH and the Kantonsspital Aarau on behalf of the ESHO, was held June 24th to 26th, 2015, in Arau and Zurich, Switzerland.

 
VIRTUAL POPULATION

14/12/2015

Contact
vip@itis.ethz.ch

 

Release of New Posable Duke V3.1!

IT’IS is now proud to announce the release of Duke cV3.1, the first of the ViP models to have been upgraded for use with the new posing method available in the multiphysics computational life sciences platform Sim4Life 2.2!

 

 
PUBLICATIONS

02/12/2015

Contact
nk@itis.ethz.ch

 

Computational Assessment of Pregnant Woman Models Exposed to Uniform ELF- Magnetic Fields: Compliance with the European Current Exposure Regulations for the General Public and Occupational Exposures at 50 Hz

Ilaria Liorni, Marta Parazzini, Serena Fiocchi, Mark Douglas, Myles Capstick, Niels Kuster, and Paolo Ravazzani, Radiation Protection Dosimetry, online ahead of print November 30, 2015

 
Other News

19/11/2015

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nk@itis.etzh.ch

 

 
PUBLICATIONS

16/11/2015

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nk@itis.ethz.ch

 

Heating and Safety Concerns of the Radio-Frequency Field in MRI

Manuel Murbach, Earl Zastrow, Esra Neufeld, Eugenia Cabot, Wolfgang Kainz, and Niels Kuster, Current Radiology Reports, Volume 3, Number 45, December 2015, online October 28, 2015

 
Other News

12/11/2015

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nk@itis.etzh.ch

 

National Future Day 2015 – Wireless Power Transfer with the Kids “Wonderful and Powerful Team”

Thursday, November 12 was 2015 Future Day at Z43, and six engaged and curious youngsters spent the day visiting our team at IT’IS, SPEAG, and ZMT laboratories.

 
VIRTUAL POPULATION

30/10/2015

Contact
vip@itis.ethz.ch

 

IT’IS Releases the Virtual Family V2.0 whole-body shells!

The Virtual Family 2.0 whole-body shells are now available for download!

 

 
VIRTUAL POPULATION

28/10/2015

Contact
vip@itis.ethz.ch

 

Virtual Family Cited by FDA Expert Witness during US Senate Committee Hearing

Jeffrey Shuren, MD, JD, Director of the Center for Devices and Radiological Health (CDRH) of the United States Food and Drug Administration (FDA), described the use of the Virtual Family (VF) models – developed in a international collaboration led by the IT’IS Foundation and the FDA – for electromagnetic, thermal, acoustic, and computational fluid dynamics simulations that could be used to supplement or even replace data from clinical investigations of new devices.

 

 
Other News

02/10/2015

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nk@itis.etzh.ch

 

New Online Release of IT'IS Database Features Acoustic Properties and T1/T2 Relaxation Times

The IT’IS Foundation announces a new release of its database of tissue properties, version 3.0 (DOI: 10.13099/VIP21000-03-0), which includes acoustic properties and T1 and T2 relaxation times.

 
PUBLICATIONS

02/10/2015

Contact
nk@itis.ethz.ch

 

Gong (2015) Thesis

Yijian Gong, “Extended Methods for Analysis of EM Exposure for Human, In Vivo and In Vitro”, PhD Thesis, Swiss Federal Institute of Technology, Thesis No. 22957, Zurich, 2015

 
PUBLICATIONS

01/10/2015

Contact
nk@itis.ethz.ch

 

Novel Sensor Model Calibration Method for Resistively Loaded Diode Detectors

Romain Meyer, Sven Kühn, Katja Pokovic, Fin Bomholt, and Niels Kuster, IEEE Transactions on Electromagnetic Compatibility, Volume 57, Early View, online July 24, 2015

 
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