NEWS
01/06/2017
PUBLICATIONS

Noninvasive Deep Brain Stimulation via Temporally Interfering Electric Fields

Nir Grossman, David Bono, Nina Dedic, Suhasa B. Kodandaramaiah, Andrii Rudenko, Ho-Jun Suk, Antonino M. Cassara, Esra Neufeld, Niels Kuster, Li-Huei Tsai, Alvaro Pascual-Leone, and Edward S. Boyden, CellVolume 169, Issue 6, pp. 1029–1041, online 1 June 2017, doi: 10.1016/j.cell.2017.05.024

The paper reports a noninvasive strategy for electrically stimulating neurons at depth. By delivering to the brain multiple electric fields at frequencies too high to recruit neural firing, but which differ by a frequency within the dynamic range of neural firing, it is possible to electrically stimulate neurons throughout a region where interference between the multiple fields results in a prominent electric field envelope modulated at the difference frequency. This temporal interference (TI) concept was validated via modeling and physics experiments, and it was verified that neurons in the living mouse brain could follow the electric field envelope. The utility of TI stimulation is demonstrated by stimulating neurons in the hippocampus of living mice without recruiting neurons of the overlying cortex. Finally, it is shown that by altering the currents delivered to a set of immobile electrodes, different motor patterns can be steerably evoked in living mice.

The scientific and technical impact of the study can be summarized as:

  • A new, noninvasive technique to stimulate deep brain structures has been developed and tested by using computational modeling and phantom measurements, as well as electrophysiological measurements in vivo;
  • TI stimulation sends interfering, low-frequency modulated, high frequency signals from multiple pairs of electrodes placed on the scalp through the brain, avoiding stimulation of other areas;
  • The results make TI stimulation a promising alternative to surgical electrical stimulation interventions such as deep brain stimulation (DBS) for e.g., Parkinson's disease patients.
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PUBLICATIONS

30/04/2007

Contact
neufeld@itis.ethz.ch

 

A New Planning Tool for Hyperthermic Cancer Treatment

Esra Neufeld, in ERCIM News, Number 69, pp. 31–32, April 2007, invited

 
Other News

04/04/2007

 

Long-term use of cellular phones and brain tumours -- increased risk associated with use for > 10 years

Lennart O Hardell, Michael Carlberg, Fredrik Söderqvist, Kjell Hansson Mild and Lloyd L Morgan, in Occup. Environ. Med., published online 4 April 2007

 
PUBLICATIONS

04/04/2007

Contact
nk@itis.ethz.ch

 

Wegmüller (2007) Thesis

Marc Simon Wegmüller, “Intra-Body Communication for Biomedical Sensor Networks,” PhD Thesi, Swiss Federal Insititute of Technologys, Thesis No. 17323, Zurich, 2007

 
PUBLICATIONS

04/04/2007

Contact
nk@itis.ethz.ch

 

Berdiñas-Torres (2007) Thesis

Verónica Berdiñas-Torres, “Exposure Systems and Dosimetry of Large-Scale In Vivo Studies,” PhD Thesis, Swiss Federal Insititute of Technology, Thesis No. 17429, Zurich, 2007

 
Other News

02/04/2007

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chavanne@itis.ethz.ch

 

 
PUBLICATIONS

02/04/2007

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nk@itis.ethz.ch

 

Feasibility of Future Epidemiological Studies on Possible Health Effects of Mobile Phone Base Stations

Georg Neubauer, Maria Feychting, Yngve Hamnerius, Leeka Kheifets, Niels Kuster, Ignacio Ruiz, Joachim Schüz, Richard Überbacher, Joe Wiart, and Martin Röösli, in Bioelectromagnetics, Volume 28, Issue 3, pp. 224–230, April 2007, online 1 November 2006

 
PUBLICATIONS

02/04/2007

Contact
nk@itis.ethz.ch

 

Carcinogenicity Study of GSM / DCS Wireless Communication Signals in B6C3F1 Mice

Thomas Tillmann, Heinrich Ernst, Sven Ebert, Niels Kuster, Wolfgang Behnke, Susanne Rittinghausen, and Clemens Dasenbrock, in Bioelectromagnetics, Volume 28, Issue 3, pp. 173–187, April 2007, online 3 October 2006

 
PUBLICATIONS

30/03/2007

Contact
nk@itis.ethz.ch

 

Worst Case Temperature Rise in a One-dimensional Tissue Model Exposed to Radiofrequency Radiation

Theodoros Samaras, Andreas Christ, and Niels Kuster, in IEEE Transactions on Biomedical Engineering, Volume 54, Issue 3, pp. 492–496, March 2007

 
AWARDS

23/03/2007

 

iWAT'07 Best Student Presentation Award

IT'IS PhD student Stefan Schild was presented the best student presentation award at the 3rd IEEE International Workshop on Antenna Technologies (iWAT'07)

 
Other News

09/03/2007

 

Recent Research on EMF and Health Risks: Swedish Report

4th annual report from SSI's Independent Expert Group on Electromagnetic Fields, 2006, Swedish Radiation Production Authority

 
Other News

12/02/2007

 

Launch of the National Research Programme on risks related to electromagnetic radiation

A new website and information brochure introducing the National Research Programme NRP 57 on risks related to electromagnetic radiation have been published today (Feb 12, 2007)

 
Other News

17/01/2007

 

Mobile phone use and risk of glioma in 5 North European countries

Anna Lahkola, Anssi Auvinen, Jani Raitanen, Minouk J. Schoemaker, Helle C. Christensen, Maria Feychting, Christoffer Johansen, Lars Klæboe, Stefan Lönn, Anthony J. Swerdlow, Tore Tynes and Tiina Salminen, in International Journal of Cancer, Published Online: 17 Jan 2007

 
Other News

06/12/2006

 

Cellular Telephone Use and Cancer Risk: Update of a Nationwide Danish Cohort

Joachim Schüz, Rune Jacobsen, Jørgen H. Olsen, John D. Boice, Jr, Joseph K. McLaughlin, and Christoffer Johansen, in Journal of the National Cancer Institute, Volume 98, Issue 23, pp. 1707–1713, December 6 2006

 
PUBLICATIONS

27/09/2006

Contact
nk@itis.ethz.ch

 

Development of Novel Whole-Body Exposure Setups for Rats Providing High Efficiency, National Toxicology Program (NTP) Compatibility and Well-Characterized Exposure

Wolfgang Kainz, Neviana Nikoloski, Walter Oesch, Veronica Berdiñas-Torres, Jürg Fröhlich, Georg Neubauer, and Niels Kuster, in Physics in Medicine and Biology, Volume 51, Number 20, pp. 5211–5229, October 2006

 

 
PUBLICATIONS

18/09/2006

Contact
nk@itis.ethz.ch

 

Characterization of the Electromagnetic Near-field Absorption in Layered Biological Tissue in the Frequency Range from 30 MHz to 6000 MHz

Andreas Christ, Theodoros Samaras, Anja Klingenböck and Niels Kuster in Physics in Medicine and Biology, Volume 51, Number 19, pp. 4951-4966, October 2006

 

 
PUBLICATIONS

15/09/2006

 

Source of Funding and Results of Studies of Health Effects of Mobile Phone Use: Systematic Review of Experimental Studies

Anke Huss, Matthias Egger, Kerstin Hug, Karin Huwiler-Müntener and Martin Röösli in Environmental Health Physics, Volume 115, Number 1, pp. 1-4, January 2007, published online September 15

 
PUBLICATIONS

13/09/2006

Contact
nk@itis.ethz.ch

 

Gene Expression Changes in Human Cells After Exposure to Mobile Phone Microwaves

Daniel Remondini, Reetta Nylund, Jukka Reivinen, Florence Poulletier de Gannes, Bernard Veyret, Isabelle Lagroye, Emmanuelle Haro, M. Angeles Trillo, Miriam Capri, Claudio Franceschi, Kathrin Schlatterer, Richard Gminski, Rudolf Fitzner, Rudolf Tauber, Jurgen Schuderer, Niels Kuster, Dariusz Leszczynski, Ferdinando Bersani and Christian Maercker, in Proteomics, Published Online: 28 Jul 2006

 

 
PUBLICATIONS

01/09/2006

Contact
nk@itis.ethz.ch

 

Pulsed Radio-Frequency Electromagnetic Fields: Dose-Dependent Effects on Sleep, the Sleep EEG and Cognitive Performance

Sabine J. Regel, Gilberte Tinguely, Jürgen Schuderer, Martin Adam, Niels Kuster, Hans-Peter Landolt, and Peter Achermann, in Journal of Sleep Research, Volume 15, Issue s1, p. 171, September 2006

 

 
PUBLICATIONS

16/08/2006

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nk@itis.ethz.ch

 

UMTS Base Station-Like Exposure, Well Being and Cognitive Performance

Sabine J. Regel, Sonja Negovetic, Martin Röösli, Veronica Berdiñas, Jürgen Schuderer, Anke Huss, Urs Lott, Niels Kuster, and Peter Achermann, in Environmental Health Perspectives, Volume 114, Number 8, pp. 1270–1275, August 2006

 

 
PUBLICATIONS

26/07/2006

Contact
nk@itis.ethz.ch

 

Electro-Optic Fiber Sensor for Amplitude and Phase Detection of Radio Frequency Electromagnetic Fields

Axel Kramer, Peter Müller, Urs Lott, Niels Kuster, and Fin Bomholt in Optics Letters, Volume 31, Issue 16, pp. 2402–2404, July 2006

 

 
PUBLICATIONS

18/07/2006

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nk@itis.ethz.ch

 

Extremely Low-Frequency Electromagnetic Field (ELF-EMF) does not Affect the Expression of α3, α5 and α7 Nicotinic Receptor Subunit Genes in SH-SY5Y Neuroblastoma Cell Line

Ruth Adele Antonini, Roberta Benfante, Cecilia Gotti, Milena Moretti, Niels Kuster, Juergen Schuderer, Francesco Clementi and Diego Fornasari, in Toxicology Letters, Volume 164, Number 3, pp. 191–288, July 2006

 

 
PUBLICATIONS

15/07/2006

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nk@itis.ethz.ch

 

Methodology of Detailed Dosimetry and Treatment of Uncertainty and Variations for In Vivo Studies

Niels Kuster, Verónica Berdiñas Torres, Neviana Nikoloski, Michael Frauscher and Wolfgang Kainz, in Bioelectromagnetics, Volume 27, Issue 5, pp. 378–391, July 2006

 

 
PUBLICATIONS

28/06/2006

 

Do GSM 900MHz Signals Affect Cerebral Blood Circulation? A Near-infrared Spectrophotometry Study

Martin Wolf, Daniel Haensse, Geert Morren, and Juerg Froehlich, in Optics Express, Volume 14, Number 13, pp. 6128–6141, June 2006

 
AWARDS

16/06/2006

 

BEMS 2006 Student Awards

IT'IS PhD students Clementine Boutry-Viellard and Sven Kühn receive student awards at the 28th Annual Meeting of the Bioelectromagnetics Society (BEMS2006) in Cancun, Mexico

 
PUBLICATIONS

14/06/2006

Contact
nk@itis.ethz.ch

 

A New 3-D Conformal PEC FDTD Scheme with User-defined Geometric Precision and Derived Stability Criterion

Stefan Benkler, Nicolas Chavannes and Niels Kuster, in IEEE Transactions on Antennas and Propagation, Volume 54, Number 6, pp. 1843–1849, June 2006

 

 
AWARDS

07/06/2006

 

ESHO 2006 Student Award

IT'IS PhD student Esra Neufeld received a student award at the 3rd meeting of the European Society for Hyperthermic Oncology (ESHO2006) in Berlin, Germany

 
PUBLICATIONS

06/06/2006

Contact
nk@itis.ethz.ch

 

Effects of Geometry Discretization Aspects on the Numerical Solution of the Bioheat Transfer Equation with the FDTD Technique

Theodoros Samaras, Andreas Christ, and Niels Kuster, in Physics in Medicine and Biology, Volume 51, No. 11, pp. N221–N229, May 2006

 

 
Other News

01/06/2006

Contact
chavanne@itis.ethz.ch

 

Virtual Prototyping Considering Different Usage Patterns

Nicolas Chavannes, Microwave Engineering Europe, June 2006

 
PUBLICATIONS

15/05/2006

Contact
nk@itis.ethz.ch

 

Analysis of the Accuracy of the Numerical Reflection Coefficient of the Finite-Difference Time-Domain Method at Planar Material Interfaces

Andreas Christ, Stefan Benkler, Jürg Fröhlich and Niels Kuster, in IEEE Transactions on Electromagnetic Compatibility, Volume 48, Issue 2, pp. 264–272, May 2006

 

 
PUBLICATIONS

15/05/2006

Contact
nk@itis.ethz.ch

 

Comparisons of Computed Mobile Phone Induced SAR in the SAM Phantom to That in Anatomically Correct Models of the Human Head

Brian B. Beard, Wolfgang Kainz, Teruo Onishi, Takahiro Iyama, Soichi Watanabe, Osamu Fujiwara, Jianqing Wang, Giorgi Bit-Babik, Antonio Faraone, Joe Wiart, Andreas Christ, Niels Kuster, Ae-Kyoung Lee, Hugo Kroeze, Martin Siegbahn, Jafar Keshvari, Houman Abrishamkar, Winfried Simon, Dirk Manteuffel, and Neviana Nikoloski, in IEEE Transactions on Electromagnetic Compatibility, Volume 48, Issue 2, pp. 397–407, May 2006

 

 
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