NEWS
01/06/2017
PUBLICATIONS

Noninvasive Deep Brain Stimulation via Temporally Interfering Electric Fields

Nir Grossman, David Bono, Nina Dedic, Suhasa B. Kodandaramaiah, Andrii Rudenko, Ho-Jun Suk, Antonino M. Cassara, Esra Neufeld, Niels Kuster, Li-Huei Tsai, Alvaro Pascual-Leone, and Edward S. Boyden, CellVolume 169, Issue 6, pp. 1029–1041, online 1 June 2017, doi: 10.1016/j.cell.2017.05.024

The paper reports a noninvasive strategy for electrically stimulating neurons at depth. By delivering to the brain multiple electric fields at frequencies too high to recruit neural firing, but which differ by a frequency within the dynamic range of neural firing, it is possible to electrically stimulate neurons throughout a region where interference between the multiple fields results in a prominent electric field envelope modulated at the difference frequency. This temporal interference (TI) concept was validated via modeling and physics experiments, and it was verified that neurons in the living mouse brain could follow the electric field envelope. The utility of TI stimulation is demonstrated by stimulating neurons in the hippocampus of living mice without recruiting neurons of the overlying cortex. Finally, it is shown that by altering the currents delivered to a set of immobile electrodes, different motor patterns can be steerably evoked in living mice.

The scientific and technical impact of the study can be summarized as:

  • A new, noninvasive technique to stimulate deep brain structures has been developed and tested by using computational modeling and phantom measurements, as well as electrophysiological measurements in vivo;
  • TI stimulation sends interfering, low-frequency modulated, high frequency signals from multiple pairs of electrodes placed on the scalp through the brain, avoiding stimulation of other areas;
  • The results make TI stimulation a promising alternative to surgical electrical stimulation interventions such as deep brain stimulation (DBS) for e.g., Parkinson's disease patients.
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PUBLICATIONS

10/05/2006

Contact
nk@itis.ethz.ch

 

ROS Release and Hsp70 Expression after Exposure to 1,800 MHz Radiofrequency Electromagnetic Fields in Primary Human Monocytes and Lymphocytes

M. Lantow, M. Lupke, J. Frahm, M. O. Mattsson, N. Kuster and M. Simko, in Radiation and Environmental Biophysics, Volume 45, Number 1, pp. 55–62, May 2006

 

 
PUBLICATIONS

01/05/2006

Contact
nk@itis.ethz.ch

 

The Dependence of Electromagnetic Far-field Absorption on Body Tissue Composition in the Frequency Range from 300 MHz to 6 GHz

Andreas Christ, Anja Klingenböck, Theodoros Samaras, Cristian Goiceanu, and Niels Kuster, in IEEE Transactions on Microwave Theory and Techniques, Volume 54, Number 5, pp. 2188–2195, May 2006

 

 
ANNUAL REPORTS

15/04/2006

Contact
nk@itis.ethz.ch

 

IT'IS Annual Report 2005

The Annual Report 2005 features key figures for 2005 and overviews of selected projects:

  • Novel Semi-Implicit FDTD Solver
  • Time and Frequency Domain Field Sensor
  • New Challenges in Compliance Testing
  • New Thermo-Solver

 
PUBLICATIONS

04/04/2006

Contact
nk@itis.ethz.ch

 

Oesch (2006) Thesis

Walter Oesch, “Controlling software for EMF laboratory studies,” PhD Thesis, Swiss Federal Insititute of Technology, Thesis No. 16346, Zurich, 2006

 
PUBLICATIONS

04/04/2006

Contact
nk@itis.ethz.ch

 

Benkler (2006) Thesis

Stefan Benkler, “Robust Conformal Subcel l Modeling for Electromagnetic Simulations in Time Domain,” PhD Thesi, Swiss Federal Insititute of Technologys, Thesis No. 16969, Zurich, 2006

 
PRESS

01/03/2006

Contact
nk@itis.ethz.ch

 

Swiss Workshop Focused on Quality in EMF Research

Janet Lathrop, a journalist specializing in RF research, gives a broad and interesting review of the Monte Verità workshop on EMF Health Risk Research organized by the IT'IS Foundation November 2005.

 
Other News

01/03/2006

 

Mobile Phone Affects Cerebral Blood Flow in Humans

Sargo Aalto, Christian Haarala, Anna Brück, Hannu Sipilä, Heikki Hämäläinen, and Juha O Rinne, in Journal of Cerebral Blood Flow & Metabolism, Volume 26, Number 7, pp. 885–890, July 2006

 
Other News

01/03/2006

 

Cellular Phones, Cordless Phones, and the Risks of Glioma and Meningioma (Interphone Study Group, Germany)

Joachim Schüz, Eva Bohler, Gabriele Berg, Brigitte Schlehofer, Iris Hettinger, Klaus Schlaefer, Jürgen Wahrendorf, Katharina Kunna-Grass, and Maria Blettner, in American Journal of Epidemiology, Volume 163, Issue 6, pp. 512–520, March 2006

 
Other News

28/02/2006

 

Childhood Leukemia and Magnetic Fields in Japan: A Case-control Study of Childhood Leukemia and Residential Power-frequency Magnetic Fields in Japan

Michinori Kabuto, Hiroshi Nitta, Seiichiro Yamamoto, Naohito Yamaguchi, Suminori Akiba, Yasushi Honda, Jun Hagihara, Katsuo Isaka, Tomohiro Saito, Toshiyuki Ojima, Yosikazu Nakamura, Tetsuya Mizoue, Satoko Ito, Akira Eboshida, Shin Yamazaki, Shigeru Sokejima, Yoshika Kurokawa, and Osami Kubo, in International Journal of Cancer, Volume 119, Issue 3, Pages 643–650, August 2006

 
PUBLICATIONS

08/02/2006

Contact
nk@itis.ethz.ch

 

Effects of 900 MHz GSM Wireless Communication Signals on DMBA-Induced Mammary Tumors in Rats

Da Yu, Yonghao Shen, Niels Kuster, Yiti Fu, and Huai Chiang, in Radiation Research, Volume 165, Number 2, pp. 174–180, February 2006

 

 
PRESS

24/01/2006

Contact
nk@itis.ethz.ch

 

EMF Health Risk Research at Monte Verità, Switzerland

The conference summary as well as the presentations of the Monte Verità conference on EMF health risk research are now available on the Monte Verità website (under "results").

 
PUBLICATIONS

01/12/2005

Contact
nk@itis.ethz.ch

 

Nonuniform Grids, Nonorthogonal Grids, Unstructured Grids, and Subgrids, and Antennas

Nicolas Chavannes and others, in “Computational Electrodynamics: The Finite-Difference Time-Domain Method, Third Edition,” Allen Taflove and Susan C. Hagness, Artech House, Inc., Boston, 2005

 

 
MAJOR EVENTS

20/11/2005

Contact
nk@itis.ethz.ch

 

EMF Health Risk Research: Lessons Learned and Recommendations for the Future

A workshop to bring together the most experienced and independent researchers worldwide to develop a vision towards improving the quality of future research on EMF and health.

 
PUBLICATIONS

31/10/2005

Contact
nk@itis.ethz.ch

 

Response, Thermal Regulatory Threshold and Thermal Breakdown Threshold of Restrained RF-Exposed Mice at 905 MHz

Sven Ebert, Sang-Jin Eom, Jürgen Schuderer, U. Apostel, Thomas Tillmann, Clemens Dasenbrock and Niels Kuster, in Physics in Medicine & Biology, Volume 50, Number 21, pp. 5203–5215, October 2005

 

 
Other News

03/10/2005

Contact
nk@itis.ethz.ch

 

New Study on aging effects of the absorption of electromagnetic radiation in the head

A study investigating the electromagnetic energy absorption and possible induced thermal stress considering worst case conditions of age dependent tissue properties, anatomical changes and thermal regulation

 
PUBLICATIONS

01/10/2005

Contact
nk@itis.ethz.ch

 

Effects of 1-Week and 6-Week Exposure to GSM/DCS Radiofrequency Radiation on Micronucleus Formation in B6C3F1 Mice

Bernd-D. Görlitz, Meike Müller, Sven Ebert, Hartmut Hecker, Niels Kuster, and Clemens Dasenbrock, in Radiation Research, Volume 164, Number 4 pt 1, pp. 431–439, October 2005

 

 
Other News

30/08/2005

 

Mobile Phone Use and Risk of Acoustic Neuroma: Results of the Interphone Case-control Study in Five North European Countries

M J Schoemaker, A J Swerdlow, A Ahlbom, A Auvinen, K G Blaasaas, E Cardis, H Collatz Christensen, M Feychting, S J Hepworth, C Johansen, L Klæboe, S Lönn, P A McKinney, K Muir, J Raitanen, T Salminen, J Thomsen and T Tynes, in British Journal of Cancer, Volume 93, Number 7, 842–848, October 2005

 
PUBLICATIONS

30/08/2005

Contact
nk@itis.ethz.ch

 

Differences in RF Energy Absorption in the Heads of Adults and Children

Andreas Christ and Niels Kuster, in Bioelectromagnetics, Volume 26, Issue S7, pp. S31–S44, December 2005

 

 
PRESS

26/08/2005

 

IT'IS Site Selected for Advertisement Shooting

Our entrance door was selected by the biggest retailer in Switzerland as a background for shooting their latest advertisement. Curiously, they are promoting mobile phones!

 
Other News

26/08/2005

Contact
oberle@itis.ethz.ch

 

IT’IS new Associate Member of ITU-R Study Group 1 – Spectrum Management

The IT’IS Foundation has become a new Associate Member of the Radiocommunication Sector of the ITU, the International Telecommunication Union within the United Nations System

 
PUBLICATIONS

26/08/2005

Contact
nk@itis.ethz.ch

 

Electromagnetic Fields Affect Transcript Levels of Apoptosis-Related Genes in Embryonic Stem Cell-derived Neural Progenitor Cells

Teodora Nikolova, Jaroslaw Czyz, Alexandra Rolletschek, Przemyslaw Blyszczuk, Jörg Fuchs, Gabriele Jovtchev, Jürgen Schuderer, Niels Kuster, and Anna M. Wobus, in The FASEB Journal, Volume 19, Number 12, pp. 1686–1688, October 2005

 

 
PUBLICATIONS

06/07/2005

Contact
nk@itis.ethz.ch

 

Dosimetric Comparison of the Specific Anthropomorphic Mannequin (SAM) to 14 Anatomical Head Models Using a Novel Definition for the Mobile Phone Positioning

Wolfgang Kainz, Andreas Christ, Tocher Kellom, Seth Seidman, Neviana Nikoloski, Brian Beard and Niels Kuster, in Physics in Medicine and Biology, Volume 50, Number 14, pp. 3423–3445, July 2005

 

 
Other News

03/06/2005

Contact
nk@itis.ethz.ch

 

New study to develop anatomical high resolution models of adults and children

Within the framework of this study, four high resolution computer models of a woman, a man and two children will be developed

 
Other News

01/06/2005

 

Childhood Cancer in Relation to Distance From High Voltage Power Lines in England and Wales: a Case-control Study

Gerald Draper, Tim Vincent, Mary E Kroll, and John Swanson, in BMJ, Volume 330, p.1290, 4 June 2005

 
Other News

01/06/2005

 

Resonance Effects Indicate a Radical-Pair Mechanism for Avian Magnetic Compass

Thorsten Ritz, Peter Thalau, John B. Phillips, Roswitha Wiltschko and Wolfgang Wiltschko, Nature 429, pp. 177-180, May 2004

 
PUBLICATIONS

01/06/2005

Contact
nk@itis.ethz.ch

 

Whole-Body Exposure to 2.45 GHz Electromagnetic Fields Does Not Alter 12-arm Radial-Maze With Reduced Access to Spatial Cues in Rats

Brigitte Cosquer, Niels Kuster and Jean-Christophe Cassel, Behavioural Brain Research, Volume 161, Issue 2, pp. 331–334, June 2005

 

 
PUBLICATIONS

01/06/2005

Contact
nk@itis.ethz.ch

 

Blood–Brain Barrier and Electromagnetic Fields: Effects of Scopolamine Methylbromide on Working Memory After Whole-body Exposure to 2.45 GHz Microwaves in Rats

Brigitte Cosquer, Anne Pereira de Vasconcelos, Jürg Fröhlich and Jean-Christophe Cassel, Behavioural Brain Research, Volume 161, Issue 2, pp. 229–237, June 2005

 

 
Other News

20/05/2005

Contact
nk@itis.ethz.ch

 

Experimental Phase of the TNO Study Completed

The experimental phase of the TNO study was successfully completed

 
Other News

17/05/2005

 

Use of Cellular Telephones and Brain Tumour Risk in Urban and Rural Areas

Hardell's newest publication tested the hypothesis of an association between the use of cellular or cordless telephones and the risk for brain tumours in different geographical areas, urban and rural

 
PRESS

22/04/2005

Contact
nk@itis.ethz.ch

 

IT'IS Foundation at the ETH 150 Years Exhibition, Welcome Tomorrow

The IT'IS Foundation presented its research achievements as part of the 150 year anniversary exhibit of the ETH Zurich at the Zurich main train station.

 
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