NEWS
01/06/2017
PUBLICATIONS

Noninvasive Deep Brain Stimulation via Temporally Interfering Electric Fields

Nir Grossman, David Bono, Nina Dedic, Suhasa B. Kodandaramaiah, Andrii Rudenko, Ho-Jun Suk, Antonino M. Cassara, Esra Neufeld, Niels Kuster, Li-Huei Tsai, Alvaro Pascual-Leone, and Edward S. Boyden, CellVolume 169, Issue 6, pp. 1029–1041, online 1 June 2017, doi: 10.1016/j.cell.2017.05.024

The paper reports a noninvasive strategy for electrically stimulating neurons at depth. By delivering to the brain multiple electric fields at frequencies too high to recruit neural firing, but which differ by a frequency within the dynamic range of neural firing, it is possible to electrically stimulate neurons throughout a region where interference between the multiple fields results in a prominent electric field envelope modulated at the difference frequency. This temporal interference (TI) concept was validated via modeling and physics experiments, and it was verified that neurons in the living mouse brain could follow the electric field envelope. The utility of TI stimulation is demonstrated by stimulating neurons in the hippocampus of living mice without recruiting neurons of the overlying cortex. Finally, it is shown that by altering the currents delivered to a set of immobile electrodes, different motor patterns can be steerably evoked in living mice.

The scientific and technical impact of the study can be summarized as:

  • A new, noninvasive technique to stimulate deep brain structures has been developed and tested by using computational modeling and phantom measurements, as well as electrophysiological measurements in vivo;
  • TI stimulation sends interfering, low-frequency modulated, high frequency signals from multiple pairs of electrodes placed on the scalp through the brain, avoiding stimulation of other areas;
  • The results make TI stimulation a promising alternative to surgical electrical stimulation interventions such as deep brain stimulation (DBS) for e.g., Parkinson's disease patients.
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ANNUAL REPORTS

15/04/2005

Contact
nk@itis.ethz.ch

 

IT'IS Annual Report 2004

The Annual Report 2004 features key figures for 2004 and overviews of selected projects:

  • Novel Conformal Meshes
  • Mobile Phone Exposure of Children vs Adults
  • Human Studies for Risk Assessment and Hyperthermia
  • Services

 
Other News

15/04/2005

Contact
oberle@itis.ethz.ch

 

Health Support Systems informational brochure

R&D Services in Medical Technology, the Health Support Systems informational brochure is now available as a PDF

 
Other News

12/04/2005

 

Cellular Telephones and Risk for Brain Tumors

H. Collatz Christensen, J. Schüz, M. Kosteljanetz, H. Skovgaard Poulsen, J. D. Boice, Jr, J. K. McLaughlin, and C. Johansen, Neurology, Volume 64, pp. 1189–1195, April 2005

 
PUBLICATIONS

01/04/2005

Contact
nk@itis.ethz.ch

 

Reevaluation and Improved Design of the TEM Cell In Vitro Exposure Unit for Replication Studies

Neviana Nikoloski, Jürg Fröhlich, Theodoros Samaras, Jürgen Schuderer and Niels Kuster, Bioelectromagnetics Vol. 26, Issue 3, pp. 215–224, April 2005

 

 
PUBLICATIONS

24/03/2005

Contact
nk@itis.ethz.ch

 

Exposure to Pulse-Modulated Radio Frequency Electromagnetic Fields Affects Regional Cerebral Blood Flow

R. Huber, V. Treyer, J. Schuderer, T. Berthold, A. Buck, N. Kuster, H. P. Landolt and P. Achermann, European Journal of Neuroscience, Vol. 21, Issue 4, pp. 1000–1006, February 2005

 

 
PUBLICATIONS

01/02/2005

Contact
nk@itis.ethz.ch

 

The Precautionary Principle in the Information Society: Effects of Pervasive Computing on Health and Enviroment

Lorenz Hilty, Siegfried Behrendt, Mathias Binswanger, Arend Bruinink, Lorenz Erdmann, Jürg Fröhlich, Andreas Köhler, Niels Kuster, Claudia Som, and Felix Würtenberger,
TA-Swiss (Center for Technology Assessment) TA46e/2005, 2003. Revised second edition, 2005

 

 
PUBLICATIONS

25/01/2005

Contact
nk@itis.ethz.ch

 

A Numerical and Experimental Comparison of Human Head Phantoms for Compliance Testing of Mobile Telephone Equipment

Andreas Christ, Nicolas Chavannes, Neviana Nikoloski, Hans-Ulrich Gerber, Katja Pokovic, and Niels Kuster, Bioelectromagnetics, Vol. 26, Issue 2, pp. 125–137, February 2005

 

 
PUBLICATIONS

25/01/2005

Contact
nk@itis.ethz.ch

 

Whole-Body Exposure to 2.45 GHz Electromagnetic Fields Does Not Alter Anxiety Responses in Rats: a Plus-Maze Study Including Test Validation

Brigitte Cosquer, Rodrigue Galani, Niels Kuster and Jean-Christophe Cassel, Behavioural Brain Research, Volume 156, Issue 1, pp. 65–74, January 2005

 

 
Other News

08/01/2005

 

Mobile Phones and Health 2004: Report by the Board of NRPB

The NRPB Board has published a review update (PDF, download 1.62 MB) of the 2000 report on Mobile Phones and Health

 
PUBLICATIONS

05/01/2005

Contact
nk@itis.ethz.ch

 

The Precautionary Principle in the Information Society. Effects of Pervasive Computing on Health and Enviroment

Niels Kuster in TA-Swiss: Center for Technology Assessment; TA46e/2005)
Pervasive Computing refers to visionary new ways of applying Information and Communication Technologies (ICT) to our daily lives

 
Other News

09/12/2004

 

WHO Releases Children's Research Agenda

The Working Group of the World Health Organization has just released its recommendations for studies relevant to the risk of adverse health effects in children from exposure to electromagnetic fields (EMFs)

 
PUBLICATIONS

01/12/2004

Contact
nk@itis.ethz.ch

 

In Vitro Exposure Apparatus for ELF Magnetic Fields

Jürgen Schuderer, Walter Oesch, Norbert Felber and Niels Kuster, Bioelectromagnetics, Volume 25, Issue 8, pp. 582–591, December 2004

 

 
PUBLICATIONS

29/11/2004

Contact
nk@itis.ethz.ch

 

Final Report on REFLEX and Project Summary Now Available

REFLEX (Risk Evaluation of Potential Environmental Hazards from Low Energy Electromagnetic Field (EMF) Exposure Using Sensitive in vitro Methods) was a 3-year joint research project within the 5th EU Framework Program

 
Other News

24/11/2004

Contact
nk@itis.ethz.ch

 

New replication study to investigate EMF induced DNA damage in human fibroblasts

Within the framework of this study, four high resolution computer models of a woman, a man and two children will be developed

 
PUBLICATIONS

01/11/2004

Contact
nk@itis.ethz.ch

 

Whole-Body Exposure to 2.45 GHz Electromagnetic Fields Does Not Alter Radial-Maze Performance in Rats

Jean-Christophe Cassel, Brigitte Cosquer, Rodrigue Galani and Niels Kuster, Behavioural Brain Research, Volume 155, Issue 1, pp. 37–43, November 2004

 

 
Other News

13/10/2004

 

Mobile Phone Use and the Risk of Acoustic Neuroma

Stefan Lönn, Anders Ahlbom, Per Hall and Maria Feychting was published in Epidemiology, Volume 15, Number 6, November 2004

 
PUBLICATIONS

04/10/2004

Contact
nk@itis.ethz.ch

 

Effects of Electromagnetic Fields on Congnitive Performance and Waking EEG

S. J. Regel, J. M. Gottselig, J. Schuderer, G. Hofer-Tinguely, N. Kuster, H.-P. Landolt, J. V. Rétey and P. Achermann in 17th CONGRESS OF THE EUROPEAN SLEEP RESEARCH SOCIETY, October 2004

 
PUBLICATIONS

04/10/2004

Contact
nk@itis.ethz.ch

 

Thermal Thresholds of Restrained RF Exposed Mice at 905 MHz

Sven Ebert, Clemens Dasenbrock, Thomas Tillmann and Niels Kuster in Proceedings of the 3rd International Workshop on Biological Effects of Electromagnetic Fields, Kos, Greece, 4-8 October 2004

 
PUBLICATIONS

01/10/2004

Contact
nk@itis.ethz.ch

 

Guidance for Exposure Design of Human Studies Addressing Health Risk Evaluations of Mobile Phones

Niels Kuster, Jürgen Schuderer, Andreas Christ, Peter Futter and Sven Ebert, Bioelectromagnetics, Volume 25, Issue 7 , pp. 524–529, October 2004

 
Other News

01/09/2004

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nk@itis.ethz.ch

 

Dutch study with UMTS exposure will be replicated in Switzerland

The Dutch TNO study investigating the effects of GSM- and UMTS-like electromagnetic fields on well being and cognitive functions in human subjects will be replicated within the Replication-TNO project

 
PUBLICATIONS

15/08/2004

Contact
nk@itis.ethz.ch

 

In Vitro Exposure Setups for RF Exposures at 900 MHz

Jürgen Schuderer, Denis Spät, Theodoros Samaras, Walter Oesch and Niels Kuster, IEEE Transactions in Microwave Theory and Techniques, Volume 52, Issue 8, pp. 2067–2075, August 2004

 

 
PUBLICATIONS

15/08/2004

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nk@itis.ethz.ch

 

High Peak SAR Exposure Unit with Tight Exposure and Environmental Control for In Vitro Experiments at 1800 MHz

Jürgen Schuderer, Theodoros Samaras, Walter Oesch, Denis Spät and Niels Kuster, IEEE Transactions in Microwave Theory and Techniques, Volume 52, Issue 8, pp. 2057–2066, August 2004

 

 
PUBLICATIONS

15/06/2004

Contact
nk@itis.ethz.ch

 

1800 MHz Radiofrequency (Mobile Phones, Different Global System for Mobile Communication Modulations) Does Not Affect Apoptosis and Heat Shock Protein 70 Level in Peripheral Blood Mononuclear Cells from Young and Old Donors

Miriam Capri, Elena Scarcella, Enrica Bianchi, Cristiana Fumelli, Pietro Mesirca, Chiara Agostini, D. Remondini, Jürgen Schuderer, Niels Kuster, Claudio Franceschi and Ferdinando Bersani, International Journal of Radiation Biology, Volume 80, Issue 6, pp. 389–397, June 2004

 

 
ANNUAL REPORTS

17/05/2004

Contact
nk@itis.ethz.ch

 

IT'IS Annual Report 2003

The Annual Report 2003 features key figures for 2003 and overviews of selected projects:

  • TRINITY
  • CSCIENCE
  • Health Risk Assessment
  • ULTRACOM

 
PUBLICATIONS

10/05/2004

Contact
nk@itis.ethz.ch

 

A Novel 3-D CPFDTD Scheme for Modeling Grid Non-conformally Aligned Transmitter Structures

Nicolas Chavannes and Niels Kuster, IEEE Transactions on Antennas and Propagation, Volume 52, Issue 5, pp. 1324–1334, May 2004

 

 
PUBLICATIONS

01/05/2004

Contact
nk@itis.ethz.ch

 

High Frequency Electromagnetic Fields (gsm Signals) Affect Gene Expression Levels in Tumor Suppressor p53-deficient Embryonic Stem Cells

Jaroslaw Czyz, Kaomei Guan, Qinghua Zeng, Teodora Nikolova, Armin Meister, Frank Schönborn, Jürgen Schuderer, Niels Kuster and Anna M. Wobus, Bioelectromagnetics, Volume 25, Issue 4, pp. 296–307, May 2004

 

 
PUBLICATIONS

01/05/2004

Contact
nk@itis.ethz.ch

 

Novel High Resolution Temperature Probe for Radiofrequency Dosimetry

Jürgen Schuderer, Thomas Schmid, Gerald Urban, Theodoros Samaras, and Niels Kuster, Physics in Medicine and Biology, Volume 49, Issue 6, pp. N83–N92, March 2004

 

 
PUBLICATIONS

04/04/2004

Contact
nk@itis.ethz.ch

 

Schuderer (2004) Thesis

Jürgen Schuderer, “EMF Risk Assessment: In Vitro Research and Sleep Studies,” PhD Thesis, Swiss Federal Insititute of Technology, Thesis No. 15347, Zurich, 2003

 
Other News

08/02/2004

Contact
murbach@itis.ethz.ch

 

New sleep study

Effects of GSM mobile phone exposure on human sleep, waking EEG, regional cerebral blood flow, performance and heart rate are investigated

 
PUBLICATIONS

15/01/2004

Contact
nk@itis.ethz.ch

 

Non-Thermal Effects of Power-Line Magnetic Fields (50 Hz) on Gene Expression Levels of Pluripotent Embryonic Stem Cells—The Role of Tumour Suppressor p53

Jaroslaw Czyz, Teodora Nikolova, Jürgen Schuderer, Niels Kuster, and Anna M. Wobus, Mutation Research/Genetic Toxicology and Environmental Mutagenesis, Volume 557, Issue 1, pp. 63–74, January 2004

 

 
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