NEWS
01/06/2017
PUBLICATIONS

Noninvasive Deep Brain Stimulation via Temporally Interfering Electric Fields

Nir Grossman, David Bono, Nina Dedic, Suhasa B. Kodandaramaiah, Andrii Rudenko, Ho-Jun Suk, Antonino M. Cassara, Esra Neufeld, Niels Kuster, Li-Huei Tsai, Alvaro Pascual-Leone, and Edward S. Boyden, CellVolume 169, Issue 6, pp. 1029–1041, online 1 June 2017, doi: 10.1016/j.cell.2017.05.024

The paper reports a noninvasive strategy for electrically stimulating neurons at depth. By delivering to the brain multiple electric fields at frequencies too high to recruit neural firing, but which differ by a frequency within the dynamic range of neural firing, it is possible to electrically stimulate neurons throughout a region where interference between the multiple fields results in a prominent electric field envelope modulated at the difference frequency. This temporal interference (TI) concept was validated via modeling and physics experiments, and it was verified that neurons in the living mouse brain could follow the electric field envelope. The utility of TI stimulation is demonstrated by stimulating neurons in the hippocampus of living mice without recruiting neurons of the overlying cortex. Finally, it is shown that by altering the currents delivered to a set of immobile electrodes, different motor patterns can be steerably evoked in living mice.

The scientific and technical impact of the study can be summarized as:

  • A new, noninvasive technique to stimulate deep brain structures has been developed and tested by using computational modeling and phantom measurements, as well as electrophysiological measurements in vivo;
  • TI stimulation sends interfering, low-frequency modulated, high frequency signals from multiple pairs of electrodes placed on the scalp through the brain, avoiding stimulation of other areas;
  • The results make TI stimulation a promising alternative to surgical electrical stimulation interventions such as deep brain stimulation (DBS) for e.g., Parkinson's disease patients.
Page 15 of 17
PUBLICATIONS

15/01/2004

Contact
nk@itis.ethz.ch

 

Dosimetric Analysis of the Carousel Setup for the Exposure of Rats at 1.62 GHz

Frank Schönborn, Katja Pokovic, Christian Brösamle, and Niels Kuster, Bioelectromagnetics, Volume 25, Issue 1, pp. 16–26, January 2004

 

 
PUBLICATIONS

01/12/2003

Contact
nk@itis.ethz.ch

 

Suitability of FDTD Based TCAD Tools for RF Design of Mobile Phones

Nicolas Chavannes, Roger Tay, Neviana Nikoloski and Niels Kuster, IEEE Antennas and Propagation Magazine, Volume 45, Issue 6, pp. 52–66, December 2003

 

 
PUBLICATIONS

01/07/2003

Contact
nk@itis.ethz.ch

 

Correction of the Numerical Reflection Coefficient of the Finite-Difference Time-Domain Method for Efficient Simulation of Vertical-Cavity Surface-Emitting Lasers

Andreas Christ, Matthias Streiff, Andreas Witzig, Niels Kuster, and Wolfgang Fichtner, Journal of the Optical Society of America B, 2003, Volume 20, Issue 7, pp. 1401–1408, July 2003

 

 
AWARDS

26/06/2003

 

BEMS 2003 Student Award

IT'IS PhD student Neviana Nikoloski received a student award at the 25th Annual Meeting of the Bioelectromagnetics Society (BEMS2003) at Maui, Hawaii, USA

 
PUBLICATIONS

01/05/2003

Contact
nk@itis.ethz.ch

 

Radio Frequency Electromagnetic Field Exposure in Humans: Estimation of SAR Distribution in the Brain, Effects on Sleep and Heart Rate

Reto Huber, Jürgen Schuderer, Thomas Graf, Kathrin Jütz, Alexander A. Borbély, Niels Kuster, and Peter Achermann, Bioelectromagnetics, Volume 24, Issue 4, pp. 262–276, May 2003

 

 
PUBLICATIONS

04/04/2003

Contact
nk@itis.ethz.ch

 

Christ (2003) Thesis

Andreas Christ, “Analysis and Improvement of the Numerical Properties of the FDTD Algorithm,” PhD Thesis, Swiss Federal Insititute of Technology, Thesis No. 15057, Zurich, 2003

 
PUBLICATIONS

01/02/2003

Contact
nk@itis.ethz.ch

 

Effect of the Meniscus at the Solid/Liquid Interface on the SAR Distribution in Petri Dishes and Flasks

Jürgen Schuderer and Niels Kuster, Bioelectromagnetics, Volume 24, Issue 2, pp. 103–108, February 2003

 

 
PUBLICATIONS

01/12/2002

Contact
nk@itis.ethz.ch

 

Correction of Numerical Phase Velocity Errors in Nonuniform FDTD Meshes

Andreas Christ, Jürg Fröhlich, and Niels Kuster, IEICE Transactions on Communications, Volume E85-B, Issue 12, pp. 2904–2915, December 2002

 

 
PUBLICATIONS

01/12/2002

Contact
nk@itis.ethz.ch

 

Towards Danger of Mobile Phones in Planes, Trains, Cars and Elevators

Axel Kramer, Jürg Fröhlich and Niels Kuster, Journal of the Physical Society of Japan, Volume 71, Issue 12, page 3100, December 2002

 

 
PUBLICATIONS

01/12/2002

Contact
nk@itis.ethz.ch

 

Electromagnetic Fields, Such as Those from Mobile Phones, Alter Regional Cerebral Blood Flow and Sleep and Waking EEG

R. Huber, V. Treyer, A.A. Borbély, J. Schuderer, J.M. Gottselig, H.-P. Landolt, E. Werth, T. Bertholod, N. Kuster, A. Buck, and P. Achermann, Journal of Sleep Research, Volume 11 Issue 4, pp. 289–295, December 2002

 

 
PUBLICATIONS

04/04/2002

Contact
nk@itis.ethz.ch

 

Chavannes (2002) Thesis

Nicolas P. Chavannes, “Local Mesh Refinement Algorithms for Enhanced Modeling Capabilities in the FDTD Method,” PhD Thesis, Swiss Federal Insititute of Technology, Thesis No. 14577, Zurich, 2002

 

 
PUBLICATIONS

03/12/2001

Contact
nk@itis.ethz.ch

 

Basis for Optimization of In Vitro Exposure Apparatus for Health Hazard Evaluations of mObile Communications

Frank Schönborn, Katja Pokovic, Michael Burkhardt, and Niels Kuster, Bioelectromagnetics, Volume 22, Issue 8, pp. 547–559, December 2001

 

 
PUBLICATIONS

01/12/2001

Contact
nk@itis.ethz.ch

 

Review of Dosimetry and Near-field Measurement Techniques for Human Exposure Evaluations and Bioexperiments

Niels Kuster, “Review of dosimetry and near-field measurement techniques for human exposure evaluations and bioexperiments,” in Communication Mobile-Effects Biologique, Claude Legris, CADAS, Acadèmie des Sciences, Paris, France, 2001

 

 
PUBLICATIONS

01/10/2001

Contact
nk@itis.ethz.ch

 

 
PUBLICATIONS

01/12/2000

Contact
nk@itis.ethz.ch

 

Experimental and Numerical Near-Field Evaluation of RF Transmitters

Katja Pokovic, Michael Burkhardt, and Niels Kuster, in Radio Frequency Radiation Dosimetry, Kluwer Academic Publishers, The Netherlands, 2000

 

 
PUBLICATIONS

01/11/2000

Contact
nk@itis.ethz.ch

 

Appropriate Modeling of the Ear for Compliance Testing of Handheld MTE with SAR Safety Limits at 900/1800 MHz

Michael Burkhardt and Niels Kuster, IEEE Transactions on Microwave Theory and Techniques, Volume 48, Issue 11 (Part 1), pp. 1927–1934, November 2000

 

 
PUBLICATIONS

01/11/2000

Contact
nk@itis.ethz.ch

 

The Dependence of Electromagnetic Energy Absorption upon Human Head Tissue Composition in the Frequency Range of 300–3000 MHz

Antonios Drossos, Veli Santomaa, and Niels Kuster, IEEE Transactions on Microwave Theory and Techniques, Volume 48, Issue 11 (Part 2), pp. 1988–1995, November 2000

 

 
PUBLICATIONS

01/10/2000

Contact
nk@itis.ethz.ch

 

Exposure to Pulsed High-frequency Electromagnetic Field During Waking Affects Human Sleep EEG

Reto Huber, Thomas Graf, Kimberly A. Cote, Lutz Wittmann, Eva Gallmann, Daniel Matter, Jürgen Schuderer, Niels Kuster, Alexander A. Borbély, and Peter Achermann, NeuroReport, Volume 11, Issue 15, pp. 3321–3325, October 2000

 

 
PUBLICATIONS

01/08/2000

Contact
nk@itis.ethz.ch

 

Millimeter-Resolution E-field Probe for Isotropic Measurement in Lossy Media Between 100 MHz and 20 GHz

Katja Pokovic, Thomas Schmid, and Niels Kuster, IEEE Transactions on Instrumentation and Measurement, Volume 49, Issue 4, pp. 873–878, August 2000

 

 
PUBLICATIONS

01/08/2000

Contact
nk@itis.ethz.ch

 

Electromagnetic and Heat Transfer Computations for Non-ionizing Radiation Dosimetry

Theodoros Samaras, Peter Regli, and Niels Kuster, Physics in Medicine and Biology, Volume 45, Issue 8, pp. 2233–2246, August 2000

 

 
PUBLICATIONS

01/07/2000

Contact
nk@itis.ethz.ch

 

Design, Optimization, Realization, and Analysis of an In Vitro System for the Exposure of Embryonic Stem Cells at 1.71 GHz

Frank Schönborn, Katja Pokovic, Anna M. Wobus, and Niels Kuster, Bioelectromagnetics, Volume 21, Issue 5, pp. 372–384, July 2000

 

 
PUBLICATIONS

01/06/2000

Contact
nk@itis.ethz.ch

 

Analysis of EEG Data from Weak-field Magnetic Stimulation of Mesial Temporal Lobe Epilepsy Patients

Jon Dobson, Timothy G. St. Pierre, Paola P. Schultheiss-Grassi, H. Gregor Wieser, and Niels Kuster, Brain Research, Volume 868, Issue 2, pp. 386–391, June 2000

 

 
PUBLICATIONS

01/05/2000

Contact
nk@itis.ethz.ch

 

 
PUBLICATIONS

01/05/2000

Contact
nk@itis.ethz.ch

 

Novel Probes and Evaluation Procedures to Assess Field Magnitude and Polarization

Katja Pokovic, Thomas Schmid, Jürg Fröhlich, and Niels Kuster, IEEE Transactions on Electromagnetic Compatibility, Volume 42, Issue 2, pp. 240–244, May 2000

 

 
PUBLICATIONS

13/04/2000

Contact
nk@itis.ethz.ch

 

Review of FDTD Time-Stepping Schemes for Efficient Simulation of Electric Conductive Media

Christian Schuster, Andreas Christ, and Wolfgang Fichtner, Microwave and Optical Technology Letters, Volume 25, Issue 1, pp. 16–21, April 2000

 

 
PUBLICATIONS

12/04/2000

Contact
nk@itis.ethz.ch

 

Spontaneous and Nitrosourea-Induced Primary Tumors of the Central Nervous System in Fischer 344 Rats Exposed to Frequency-modulated Microwave Fields

W. Ross Adey, Craig V. Buys, Robert J. Higgins, Robert A. Jones, Charles J. Kean, Niels Kuster, Anne MacMurray, Robert B. Stagg, and Grenith Zimmermann, Journal of Cancer Research, Volume 60, April 2000

 

 
PUBLICATIONS

04/04/2000

Contact
nk@itis.ethz.ch

 

Schönborn (2000) Thesis

Frank J. Schönborn, “Risk Assessment to EMF Exposure ,” PhD Thesis, Swiss Federal Insititute of Technology, Thesis No. 13839, Zurich, 2000

 

 
PUBLICATIONS

01/12/1999

Contact
nk@itis.ethz.ch

 

Review of Exposure Assessment for Handheld Mobile Communications, Devices and Antenna Studies for Optimized Performance

Michael Burkhardt and Niels Kuster, in Review of Radio Science 1996-1999, W.R. Stone, Ed., Oxford University Press, 1999

 

 
PUBLICATIONS

01/12/1999

Contact
nk@itis.ethz.ch

 

Antenna Near-field Evaluations and Compliance Tests with Safety Standards

Niels Kuster, in Mobile Antenna Systems Handbook, K. Fujimoto and J. R. James, Eds. Artech House Publisher, Boston / London, second edition, 1999

 

 
PUBLICATIONS

01/09/1999

Contact
nk@itis.ethz.ch

 

Spontaneous and Nitrosourea-Induced Primary Tumors of the Central Nervous System in Fischer 344 Rats Chronically Exposed to 836 MHz Modulated Microwaves

W. R. Adey, C. V. Buys, R. J. Higgins, R. A. Jones, C. J. Kean, N. Kuster, A. MacMurray, R. B. Stagg, G. Zimmermann, J. L. Phillips, and W. Haggren, Journal of Radiation Research, Volume 152, Issue 3, pp. 293–302, September 1999

 

 
Page 15 of 17
 
first page previous page 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 ALL next page last page
 
CONTACT INFORMATION
 
+41 44 245 96 96