NEWS
01/06/2017
PUBLICATIONS

Noninvasive Deep Brain Stimulation via Temporally Interfering Electric Fields

Nir Grossman, David Bono, Nina Dedic, Suhasa B. Kodandaramaiah, Andrii Rudenko, Ho-Jun Suk, Antonino M. Cassara, Esra Neufeld, Niels Kuster, Li-Huei Tsai, Alvaro Pascual-Leone, and Edward S. Boyden, CellVolume 169, Issue 6, pp. 1029–1041, online 1 June 2017, doi: 10.1016/j.cell.2017.05.024

The paper reports a noninvasive strategy for electrically stimulating neurons at depth. By delivering to the brain multiple electric fields at frequencies too high to recruit neural firing, but which differ by a frequency within the dynamic range of neural firing, it is possible to electrically stimulate neurons throughout a region where interference between the multiple fields results in a prominent electric field envelope modulated at the difference frequency. This temporal interference (TI) concept was validated via modeling and physics experiments, and it was verified that neurons in the living mouse brain could follow the electric field envelope. The utility of TI stimulation is demonstrated by stimulating neurons in the hippocampus of living mice without recruiting neurons of the overlying cortex. Finally, it is shown that by altering the currents delivered to a set of immobile electrodes, different motor patterns can be steerably evoked in living mice.

The scientific and technical impact of the study can be summarized as:

  • A new, noninvasive technique to stimulate deep brain structures has been developed and tested by using computational modeling and phantom measurements, as well as electrophysiological measurements in vivo;
  • TI stimulation sends interfering, low-frequency modulated, high frequency signals from multiple pairs of electrodes placed on the scalp through the brain, avoiding stimulation of other areas;
  • The results make TI stimulation a promising alternative to surgical electrical stimulation interventions such as deep brain stimulation (DBS) for e.g., Parkinson's disease patients.
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AWARDS

22/06/1999

 

Curtis Carl Johnson Memorial Award for First Place Poster (1999)

Katja Pokovic won the first place student award at the 1999 meeting of the Bioelectromagnetics Society (BEMS1999), in Long Beach, California, USA

 
PUBLICATIONS

04/04/1999

Contact
nk@itis.ethz.ch

 

Burkhardt (1999) Thesis

Michael Burkhardt, “Contributions toward Uncertainty Assessments and Error Minimization of FDTD Simulations Involving Complex Dielectric ,” PhD Thesis, Swiss Federal Insititute of Technology, Thesis No. 13176, Zurich, 1999

 

 
PUBLICATIONS

04/04/1999

Contact
nk@itis.ethz.ch

 

Pokovic (1999) Thesis

Katja Pokovic, “Advanced Electromagnetic Probes for ,” PhD Thesis, Swiss Federal Insititute of Technology, Thesis No. 13334, Zurich, 1999

 

 
PUBLICATIONS

01/12/1998

Contact
nk@itis.ethz.ch

 

Compliance Testing of Hand-held Mobile Communications Equipment

Niels Kuster, in Wireless Phones and Health, George L. Carlo, Ed., Kluwer Academic Publishers, Boston / Dordrecht / London, November 1998

 

 
PUBLICATIONS

30/11/1998

Contact
nk@itis.ethz.ch

 

Comparison Between Numerical and Experimental Near-field Evaluation of a DCS1800 Mobile Telephone

Achim Bahr, Ralf Käastle, Sheng-Gen Pan, Thomas Schmid, Thomas Becks, and Niels Kuster, Radio Science, Volume 33, Issue 6, pp. 1553–1563, November-December 1998

 

 
PUBLICATIONS

20/08/1998

Contact
nk@itis.ethz.ch

 

Miniature Dielectric-Loaded Personal Telephone Antennas with Low User Exposure

Oliver Leisten, Y. Vardaxoglou, Thomas Schmid, B. Rosenberger, E. Agboraw, Niels Kuster, and G. Nicolaidis, Electronics Letters (IEEE), Volume 34, Issue 17, pp. 1628–1629, August 1998

 

 
AWARDS

10/06/1998

 

BEMS 1998 First Place Platform – Curtis Carl Johnson Memorial Award

Michael Burkhardt won the first place student award at the 1999 meeting of the Bioelectromagnetics Society (BEMS1998), in St. Pete Beach, Florida, USA

 
PUBLICATIONS

01/06/1998

Contact
nk@itis.ethz.ch

 

Dipole Configurations with Strongly Improved Radiation Efficiency for Hand-held Transceivers

Roger Yew-Siow Tay, Quirino Balzano, and Niels Kuster, IEEE Transactions on Antennas and Propagation, Volume 46, Issue 6, pp. 798–806, June 1998

 

 
ANNUAL REPORTS

01/06/1998

Contact
nk@itis.ethz.ch

 

BIOEM Group Annual Progess Report 1997

The Annual Progress Report 1997 features key figures for 1997 and overviews of selected projects:

  • CAD Tool for Antenna Analysis and Optimization
  • Optimization of Industrial Microwave Ovens
  • New Generation of Isotropic Broadband E- and H-Field Probes
  • Broadband Calibration Procedures Providing Greatest Precision
  • Studies of Brain Cancer Promotion by Cellular Phone Exposure

 
PUBLICATIONS

04/04/1998

Contact
nk@itis.ethz.ch

 

Sundberg (1998) Thesis

Magnus Sundberg, “Analysis of Industrial Microwave Ovens,” PhD Thesis, Department of Microwave Technology, Chalmers University of Technology, 1998

 
PUBLICATIONS

15/02/1998

Contact
nk@itis.ethz.ch

 

Differences in Energy Absorption Between Heads of Adults and Children in the Near Field of Sources

Frank Schönborn, Michael Burkhardt, and Niels Kuster, Health Physics, Volume 74, Issue 2, pp. 160–168, February 1998

 

 
PUBLICATIONS

01/12/1997

Contact
nk@itis.ethz.ch

 

Dosimetric Needs for Laboratory and Epidemiological Research in Non-thermal Effects of RF Electromagnetic Fields

Niels Kuster, in Non-Thermal Effects of RF Electromagnetic Fields, Proceedings of the International Seminar on Biological Effects of Non-Thermal Pulsed and Amplitude Modulated RF Electromagnetic Fields and Related Health Risks, Munich, Germany, November 20–21, 1996, J.H. Bernhardt, R. Matthes, M. H. Repacholi (eds.) ICNIRP (International Commission on Non-Ionizing Radiation Protection) Publication, 3/97, pp. 27–34, 1997

 

 
PUBLICATIONS

01/11/1997

Contact
nk@itis.ethz.ch

 

The Dependence of Electromagnetic Energy Absorption Upon Human-head Modeling at 1800 MHz

Klaus Meier, Volker Hombach, Ralf Kästle, Roger Yew-Siow Tay and Niels Kuster, IEEE Transactions on Microwave Theory and Techniques, Volume 45, Issue 11, pp. 2058–2062, November 1997

 

 
PUBLICATIONS

01/11/1997

Contact
nk@itis.ethz.ch

 

Exposure Setup to Test Effects of Wireless Communications Systems on the CNS

Michael Burkhardt, Yuri Spinelli, and Niels Kuster, Health Physics, Volume 73, Issue 5, pp. 770–778, November 1997

 

 
PUBLICATIONS

01/09/1997

Contact
nk@itis.ethz.ch

 

Effect of Global System for Mobile Communication Microwave Exposure on the Genomic Response of the Rat Brain

K. Fritze, C. Wiessner, Niels Kuster, C. Sommer, P. Gass, D. M. Hermann, M. Kiessling, and K.-A. Hossmann, Neuroscience (IBRO), Volume 81, Issue 3, pp. 627–639, September 1997

 

 
ANNUAL REPORTS

01/06/1997

Contact
nk@itis.ethz.ch

 

BIOEM Group Annual Progess Report 1996

The Annual Progress Report 1996 features key figures for 1996 and overviews of selected projects:

  • Electromagnetic Simulation Platform for Microsystems and Wireless Technology
  • Antenna Optimization in Handheld MTE
  • Differences in Exposure Between Adults and Children
  • Generic Twin Phantom
  • Studies of CNS Effects Caused by Mobile Phone Exposure

 
PUBLICATIONS

31/05/1997

Contact
nk@itis.ethz.ch

 

Effects of Electromagnetic Field Exposure on the Genomic Response and Blood-Brain Barrier Permeability in the Rat CNS

C. Sommer, K. Fritze, C. Wiessner, Niels Kuster, D. Hermann, K.-A. Hossmann, and M. Kiessling, Clinical Neuropathology, Volume 16, p. 289, 1997

 

 
PUBLICATIONS

31/05/1997

Contact
nk@itis.ethz.ch

 

Acute Effects of GSM Electromagnetic Field Exposure on the Genomic Response of the rat CNS

C. Sommer, K. Fritze, C. Wiessner, Niels Kuster, D. Hermann, K.-A. Hossmann, and M. Kiessling, Journal of Cerebral Blood Flow and Metabolism, Volume 17, Suppl. 1, p. S486, 1997

 

 
PUBLICATIONS

01/05/1997

Contact
nk@itis.ethz.ch

 

Dosimetric Evaluation of Handheld Mobile Communications Equipment with Known Precision

Niels Kuster, Ralph Kästle, and Thomas Schmid, (invited paper), IEICE Transactions on Communications, Volume E80-B, no. 5, pp. 645–652, May 1997

 

 
PUBLICATIONS

04/04/1997

Contact
nk@itis.ethz.ch

 

Tay (1997) Thesis

Roger Yew-Siow Tay, “Contributions Towards the Optimization of Hand-held Mobile Telecommunication Equipment by Computational Electromagnetics,” PhD Thesis, Swiss Federal Insititute of Technology, Thesis No. 12311, Zurich, 1997

 

 
PUBLICATIONS

01/01/1997

Contact
nk@itis.ethz.ch

 

Experimental and Numerical Dosimetry

Niels Kuster and Quirino Balzano, pp. 13–64, in Niels Kuster, Quirino Balzano, and James C. Lin, Eds., “Mobile Communications Safety,” Chapman & Hall, London, 1996/7

 

 
PUBLICATIONS

15/12/1996

Contact
nk@itis.ethz.ch

 

Numerical and Experimental Dosimetry of Petri Dish Exposure Setups

Michael Burkhardt, Katja Pokovic, Marcel Gnos, Thomas Schmid, and Niels Kuster, Journal of the Bioelectromagnetic Society, Volume 17, Issue 6, 1996, pp. 483–493

 

 
PUBLICATIONS

15/10/1996

Contact
nk@itis.ethz.ch

 

The Dependence of EM Energy Absorption Upon Human Head Modeling at 900 MHz

Volker Hombach, Klaus Meier, Michael Burkhardt, Eberhard Kühn, and Niels Kuster, IEEE Transactions on Microwave Theory and Techniques, Volume 44, Issue 10, Part 2, pp. 1865–1873, October 1996

 

 
PUBLICATIONS

15/10/1996

Contact
nk@itis.ethz.ch

 

Broadband Calibration of E-field Probes in Lossy Media

Klaus Meier, Michael Burkhardt, Thomas Schmid, and Niels Kuster, IEEE Transactions on Microwave Theory and Techniques, Volume 44, Issue 10, pp. 1954–1962, October 1996

 

 
PUBLICATIONS

15/04/1996

Contact
nk@itis.ethz.ch

 

Effects of Low Energy Emission Therapy in Chronic Psychophysiological Insomnia

Boris Pasche, Milton Erman, Roza Hajdukovic, Merrill M. Mittler, Martin Reite, Lisa Higgs, Niels Kuster, Claude Rossel, Urania Dafni, David Amato, Alexandre Barbault, and Jean-Pierre Lebet, Sleep, Volume 19, Issue 4, pp. 327–337, April 1996

 

 
PUBLICATIONS

04/04/1996

Contact
nk@itis.ethz.ch

 

Meier (1996) PhD Thesis

Klaus Meier, "Scientific Bases for Dosimetric Assessments in Compliance Tests,” PhD Thesis, Swiss Federal Insititute of Technology, Thesis No. 11722, Zurich, 1996

 

 
PUBLICATIONS

15/01/1996

Contact
nk@itis.ethz.ch

 

Automated E-field Scanning System for Dosimetric Assessments

Thomas Schmid, Oliver Egger, and Niels Kuster, IEEE Transactions on Microwave Theory and Techniques, Volume 44, Issue 1, pp. 105–113, January 1996

 

 
PUBLICATIONS

15/12/1994

Contact
nk@itis.ethz.ch

 

Performance of the Generalized Multipole Technique (GMT/MMP) in Antenna Design and Optimization

Roger Yew Tay and Niels Kuster, in Special Issue on Generalized Multipole Technique (GMT), Applied Computational Electromagnetics Society (ACES) Journal, Volume 9, Issue 3, pp. 79–89, December 1994

 

 
PUBLICATIONS

15/05/1994

Contact
nk@itis.ethz.ch

 

A Block Iterative Technique to Expand MMP's Applicability to EM Problems of Higher Complexity

Niels Kuster and Lars H. Bomholt, IEEE Transactions on Microwave Theory and Techniques, Volume 42, Issue 5, pp. 875–883, May 1994

 

 
PUBLICATIONS

15/01/1994

Contact
nk@itis.ethz.ch

 

Sleep Inducing Effects of Low Energy Emission Therapy

Martin Reite, Lisa Higgs, Jean-Pierre Lebet, Niels Kuster, Urania Dafni, David Amato, and Boris Pasche, Journal of the Bioelectromagnetics Society, Volume 15, Issue 1, pp. 67–75, January 1994

 

 
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