NEWS
01/06/2017
PUBLICATIONS

Noninvasive Deep Brain Stimulation via Temporally Interfering Electric Fields

Nir Grossman, David Bono, Nina Dedic, Suhasa B. Kodandaramaiah, Andrii Rudenko, Ho-Jun Suk, Antonino M. Cassara, Esra Neufeld, Niels Kuster, Li-Huei Tsai, Alvaro Pascual-Leone, and Edward S. Boyden, CellVolume 169, Issue 6, pp. 1029–1041, online 1 June 2017, doi: 10.1016/j.cell.2017.05.024

The paper reports a noninvasive strategy for electrically stimulating neurons at depth. By delivering to the brain multiple electric fields at frequencies too high to recruit neural firing, but which differ by a frequency within the dynamic range of neural firing, it is possible to electrically stimulate neurons throughout a region where interference between the multiple fields results in a prominent electric field envelope modulated at the difference frequency. This temporal interference (TI) concept was validated via modeling and physics experiments, and it was verified that neurons in the living mouse brain could follow the electric field envelope. The utility of TI stimulation is demonstrated by stimulating neurons in the hippocampus of living mice without recruiting neurons of the overlying cortex. Finally, it is shown that by altering the currents delivered to a set of immobile electrodes, different motor patterns can be steerably evoked in living mice.

The scientific and technical impact of the study can be summarized as:

  • A new, noninvasive technique to stimulate deep brain structures has been developed and tested by using computational modeling and phantom measurements, as well as electrophysiological measurements in vivo;
  • TI stimulation sends interfering, low-frequency modulated, high frequency signals from multiple pairs of electrodes placed on the scalp through the brain, avoiding stimulation of other areas;
  • The results make TI stimulation a promising alternative to surgical electrical stimulation interventions such as deep brain stimulation (DBS) for e.g., Parkinson's disease patients.
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PUBLICATIONS

30/09/2015

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nk@itis.ethz.ch

 

Convex Optimization of MRI Exposure for Mitigation of RF-Heating from Active Medical Implants

Juan Córcoles, Earl Zastrow, and Niels Kuster, Physics in Medicine and Biology, Volume 60, Issue 18, pp. 7293–7308, September 2015, online September 8, 2015

 
PUBLICATIONS

24/09/2015

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nk@itis.ethz.ch

 

Virtual Population-Based Assessment of the Impact of 3 Tesla Radiofrequency Shimming and Thermoregulation on Safety and B1+ Uniformity

Manuel Murbach, Esra Neufeld, Eugenia Cabot, Earl Zastrow, Juan Córcoles, Wolfgang Kainz, and Niels Kuster, Magnetic Resonance in Medicine, Early View, September 2015, online September 24, 2015

 
AWARDS

03/09/2015

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nk@itis.ethz.ch

 

IT’IS Foundation and ZMT Zurich Medtech Sim4Life-CAPITALIS Project Nominated for CTI Swiss Medtech 2015 Award

The Commission for Technology and Innovation CTI has nominated the research project entitled “S4L-CAPITALIS – In Silico Analysis and Optimization of Neurovascular and Neurological Devices and Treatments in the Head”, submitted by the IT’IS Foundation together with partner ZMT Zurich Medtech AG, for the prestigious CTI Swiss Medtech 2015 Award

 
PUBLICATIONS

04/08/2015

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nk@itis.ethz.ch

 

Full-Wave Acoustic and Thermal Modeling of Transcranial Ultrasound Propagation and Investigation of Skull-Induced Aberration Correction Techniques: A Feasibility Study

Adamos Kyriakou, Esra Neufeld, Beat Werner, Gábor Székely, and Niels Kuster, Journal of Therapeutic Ultrasound, Volume 3, Issue 11, July 2015, online July 31, 2015

 
Other News

01/07/2015

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nk@itis.etzh.ch

 

BioEM2015 Technical Program Committee Co-Chaired by Prof. Niels Kuster of the IT’IS Foundation

BioEM2015, the annual joint meeting of the Bioelectromagnetics Society (BEMS) and the European BioElectromagnetics Association (EBEA), was held June 14 – 19, 2015 at the Asilomar Conference Center in Pacific Grove, California. Prof. Niels Kuster of the IT’IS Foundation and treasurer of the EBEA, represented the EBEA as co-chair of the BioEM2015 Technical Program Committee.

 
Other News

29/06/2015

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nk@itis.etzh.ch

 

ESHO2015 – the 30th Annual Meeting of the European Society for Hyperthermic Oncology, Co-organized by the IT'IS Foundation

The IT’IS Foundation for Research on Information Technologies in Society together with the Kantonsspital Aarau joined forces to organize the 30th annual meeting of the European Society for Hyperthermic OncologyESHO2015 – the flagship event of the thermal cancer therapy community, held June 24 – 26, 2015 in Aarau and Zurich.

 
AWARDS

31/05/2015

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nk@itis.ethz.ch

 

IT’IS/SPEAG win the Best Symposium Paper Award at the APEMC2015 Conference

Our paper “EMC/EMI Near-field Testbed for EM Phasor Measurements Using Active Optical Sensors,” featuring the latest research in near-field EMC/EMI scanning technologies implemented in SPEAG’s TDS and ICEy systems, was awarded the Best Symposium Paper Award at the 2015 Asia-Pacific International EMC Symposium in Taipei, Taiwan.

 
PUBLICATIONS

19/05/2015

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nk@itis.ethz.ch

 

Rapid Method for Thermal Dose-Based Safety Supervision During MR Scans

Esra Neufeld, Maximilian Fuetterer, Manuel Murbach, and Niels Kuster, Bioelectromagnetics, Volume 36, Issue 5, pp. 398–407, July 2015, online May 11, 2015

 
Other News

13/05/2015

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nk@itis.etzh.ch

 

 
PUBLICATIONS

22/04/2015

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nk@itis.ethz.ch

 

MIDA: A Multimodal Imaging-Based Detailed Anatomical Model of the Human Head and Neck

Maria Iacono, Esra Neufeld, Esther Akinnagbe, Kelsey Bower, Johanna Wolf, Ioannis Oikonomidis, Deepika Sharma, Bryn Lloyd, Bertram Wilm, Michael Wyss, Klaas Pruessmann, Andras Jakab, Nikos Makris, Ethan Cohen, Niels Kuster, Wolfgang Kainz, and Leonardo Angelone, PLoS ONE, Volume 10, Issue 4, online April 22, 2015

 
ANNUAL REPORTS

21/04/2015

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nk@itis.ethz.ch

 

IT'IS Annual Report 2014

The Annual Report 2014 features key figures for 2014 and overviews of selected projects:

  • Interference and Compatibility Evaluation System (ICEy)
  • Virtual Population 2.0 & 3.0 – High Resolution Anatomical Models for Medical Device Evaluation
  • Sim4Life: A Computable, Functionalized Anatomical Model-Centered Approach to Computational Life Scienes
  • Harnessing Technology to Create Advanced RF Hyperthermia Delivery Concepts

 
PUBLICATIONS

17/04/2015

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nk@itis.ethz.ch

 

Compliance Testing Methodology for Wireless Power Transfer Systems

Jagadish Nadakuduti, Mark Douglas, Lin Lu, Andreas Christ, Paul Guckian, and Niels Kuster, IEEE Transactions on Power Electronics, Volume 30, Issue 11, pp. 6264 – 6273; online February 19, 2015

 

 

 
Other News

17/03/2015

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nk@itis.etzh.ch

 

Wrapping up ARIMMORA – Risk Assessment Workshop and Final General Assembly Meeting at IARC in Lyon, March 9 – 13, 2015

The EU-funded consortium on Advanced Research on Interaction Mechanisms of electroMagnetic exposures with Organisms for Risk Assessment (ARIMMORA) convened for the final time March 9 – 13, 2015 at the International Agency for Research on Cancer (IARC) in Lyon for a risk assessment workshop and final General Assembly meeting.

 
Other News

16/03/2015

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nk@itis.etzh.ch

 

Two Great Research Organizations are Defining Next Generation Phantom Testing in the Emerging Market for Wearable Devices

Defining the road ahead for wearable devices is another challenge in the growth of IOT.

 
Other News

26/02/2015

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nk@itis.etzh.ch

 

IT’IS Attends Brain Simulation Workshop on Computer Modeling of Focused Ultrasound

The IT’IS Foundation was one of 17 organizations invited by the Focused Ultrasound Foundation to contribute to the Brain Workshop on Treatment Envelope & Simulation held February 2 – 3, 2015 in Charlottesville VA, USA.

 
PUBLICATIONS

19/02/2015

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nk@itis.ethz.ch

 

Inter-Individual and Intra-Individual Variation of the Effects of Pulsed RF EMF Exposure on the Human Sleep EEG

Caroline Lustenberger, Manuel Murbach, Laura Tüshaus, Flavia Wehrle, Niels Kuster, Peter Achermann, and Reto Huber, Bioelectromagnetics, Volume 36, Issue 3, pp. 169–177, April 2015, online February 17, 2015

 
PUBLICATIONS

16/02/2015

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nk@itis.ethz.ch

 

The Discrepancy between Maximum In Vitro Exposure Levels and Realistic Conservative Exposure Levels of Mobile Phones Operating at 900/1800 MHz

Gernot Schmid and Niels Kuster, Bioelectromagnetics, Volume 36, Issue 2, pp. 133–148, February 2015, online January 30, 2015

 
VIRTUAL POPULATION

20/01/2015

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nk@itis.etzh.ch

 

Award of 2014 Rotblat Medal to Virtual Family Developers Featured on medicalphysicsweb

The award of 2014 Rotblat Medal to Virtual Family developers, the paper, and the IT’IS Foundation’s ongoing contribution to computational life sciences were highlighted in a recent column at medicalphysicsweb

 
AWARDS

19/01/2015

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nk@itis.ethz.ch

 

Virtual Family Wins 2014 Physics in Medicine & Biology Citations Prize

The Physics in Medicine & Biology Citations Prize, the Rotblat Medal, for 2014 has been awarded to the IT’IS Foundation and colleagues for the paper “The Virtual Family–Development of surface-based anatomical models of two adults and two children for dosimetric simulations” by A. Christ et al.

 
MAJOR EVENTS

18/01/2015

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nk@itis.ethz.ch

 

Registration Open for ESHO2015

Registration Open for ESHO2015, the 30th Annual Meeting of the EUROPEAN SOCIETY for HYPERTHERMIC ONCOLOGY, Co-Hosted by the IT'IS Foundation

 
PUBLICATIONS

16/01/2015

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nk@itis.ethz.ch

 

Human Exposure from Pulsed Magnetic Field Therapy Mats: A Numerical Case Study with Three Commercial Products

Valerio De Santis, Mark Douglas, Jagadish Nadakuduti, Stefan Benkler, Xi Lin Chen, and Niels Kuster, Bioelectromagnetics, Volume 36, Issue 2, pp. 149–161, February 2015, online January 16, 2015

 
VIRTUAL POPULATION

13/01/2015

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nk@itis.etzh.ch

 

IT’IS Releases New Online Fluid Properties Database and Publishes References Used to Determine Database Values

The IT’IS Foundation announces the release of a new database of fluid properties to complement the existing material parameters database. The new database compiles values on temperature-dependent viscosity, density, heat capacity, and thermal conductivity values for specific fluids. Also newly available are tabulated lists of the references used to determine the values in both the material parameters and fluid properties databases. The new format of the reference list links each database entry to a pdf of the reference(s) used to generate the value.

 
PUBLICATIONS

11/12/2014

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nk@itis.ethz.ch

 

Genetic Analysis of Circadian Responses to Low Frequency Electromagnetic Fields in Drosophila melanogaster

Giorgio Fedele, Mathew Edwards, Supriya Bhutani, John Hares, Manuel Murbach, Edward Green, Stephane Dissel, Michael Hastings, Ezio Rosato, and Charalambos Kyriacou, PLoS Genetics, Volume 10, Issue 12, online December 4, 2014

 
PUBLICATIONS

05/12/2014

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nk@itis.ethz.ch

 

Kyriakou (2014) Thesis

Adamos Kyriakou, “Multi-Physics Computational Modeling of Focused Ultrasound Therapies”, PhD Thesis, Swiss Federal Insititute of Technology, Thesis No. 22413, Zurich, 2014

 
Other News

25/11/2014

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nk@itis.etzh.ch

 

SPEAG & IT'IS Night 2014: A Smashing Bash!

The red carpet was rolled out at the Volkshaus at Helvetiaplatz on the evening of Friday, November 21st to welcome attendees of the jubilee party to celebrate the 20th anniversary of SPEAG and the 15th anniversary of the IT’IS Foundation.

 
Other News

17/11/2014

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nk@itis.etzh.ch

 

Spectacular Applied Research (SAR) – 2014 National Future Day

Thursday, November 13 was 2014 Future Day at Z43, and eleven curious and enthousiastic young adults spent a day visiting our team at IT’IS, SPEAG, and ZMT laboratories.

 
PUBLICATIONS

03/11/2014

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nk@itis.ethz.ch

 

Quantification of RF-Exposure of the Fetus Using Anatomical CAD-Models in Three Different Gestational Stages

Eugenia Cabot, Andreas Christ, Barbara Bühlmann, Marcel Zefferer, Nicolas Chavannes, Jurriaan F. Bakker, Gerard C. van Rhoon, and Niels Kuster, Health Physics, Volume 107, Issue 5, pp. 369381, online November 2014

 
PRESS

30/09/2014

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nk@itis.ethz.ch

 

Medicalphysicsweb Column Highlights IT'IS Latest Paper on The Virtual Population 3.0

Medicalphysicsweb dedicates a column to IT'IS latest paper on The Virtual Population 3.0

 
VIRTUAL POPULATION

30/09/2014

Contact
nk@itis.ethz.ch

 

Medicalphysicsweb Column Highlights IT'IS Latest Paper on The Virtual Population 3.0

Medicalphysicsweb dedicates a column to IT'IS latest paper on The Virtual Population 3.0

 
PUBLICATIONS

29/09/2014

Contact
nk@itis.ethz.ch

 

Dosimetric Study of Fetal Exposure to Uniform Magnetic Fields at 50 Hz

Ilaria Liorni, Marta Parazzini, Serena Fiocchi, Mark Douglas, Myles Capstick, Marie-Christine Gosselin, Niels Kuster, and Paolo Ravazzani, Bioelectromagnetics, Volume 35, Issue 8, pp. 580597, online September 29, 2014

 
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