NEWS
01/06/2017
PUBLICATIONS

Noninvasive Deep Brain Stimulation via Temporally Interfering Electric Fields

Nir Grossman, David Bono, Nina Dedic, Suhasa B. Kodandaramaiah, Andrii Rudenko, Ho-Jun Suk, Antonino M. Cassara, Esra Neufeld, Niels Kuster, Li-Huei Tsai, Alvaro Pascual-Leone, and Edward S. Boyden, CellVolume 169, Issue 6, pp. 1029–1041, online 1 June 2017, doi: 10.1016/j.cell.2017.05.024

The paper reports a noninvasive strategy for electrically stimulating neurons at depth. By delivering to the brain multiple electric fields at frequencies too high to recruit neural firing, but which differ by a frequency within the dynamic range of neural firing, it is possible to electrically stimulate neurons throughout a region where interference between the multiple fields results in a prominent electric field envelope modulated at the difference frequency. This temporal interference (TI) concept was validated via modeling and physics experiments, and it was verified that neurons in the living mouse brain could follow the electric field envelope. The utility of TI stimulation is demonstrated by stimulating neurons in the hippocampus of living mice without recruiting neurons of the overlying cortex. Finally, it is shown that by altering the currents delivered to a set of immobile electrodes, different motor patterns can be steerably evoked in living mice.

The scientific and technical impact of the study can be summarized as:

  • A new, noninvasive technique to stimulate deep brain structures has been developed and tested by using computational modeling and phantom measurements, as well as electrophysiological measurements in vivo;
  • TI stimulation sends interfering, low-frequency modulated, high frequency signals from multiple pairs of electrodes placed on the scalp through the brain, avoiding stimulation of other areas;
  • The results make TI stimulation a promising alternative to surgical electrical stimulation interventions such as deep brain stimulation (DBS) for e.g., Parkinson's disease patients.
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Other News

21/08/2014

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PUBLICATIONS

21/08/2014

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nk@itis.ethz.ch

 

Development of a New Generation of High-Resolution Anatomical Models for Medical Device Evaluation: The Virtual Population 3.0

Marie-Christine Gosselin, Esra Neufeld, Heidi Moser, Eveline Huber, Silvia Farcito, Livia Gerber, Maria Jedensjö, Isabel Hilber, Fabienne Di Gennaro, Bryn Lloyd, Emilio Cherubini, Dominik Szczerba, Wolfgang Kainz, and Niels Kuster, Physics in Medicine and Biology, Volume 59, Issue 18, pp. 5287–5303, online August 21, 2014

 
VIRTUAL POPULATION

21/08/2014

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nk@itis.ethz.ch

 

Development of a New Generation of High-Resolution Anatomical Models for Medical Device Evaluation: The Virtual Population 3.0

Marie-Christine Gosselin, Esra Neufeld, Heidi Moser, Eveline Huber, Silvia Farcito, Livia Gerber, Maria Jedensjö, Isabel Hilber, Fabienne Di Gennaro, Bryn Lloyd, Emilio Cherubini, Dominik Szczerba, Wolfgang Kainz, and Niels Kuster, Physics in Medicine and Biology, Volume 59, Issue 18, pp. 5287–5303, online August 21, 2014

 
VIRTUAL POPULATION

21/08/2014

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nk@itis.etzh.ch

 

 
Other News

16/08/2014

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nk@itis.etzh.ch

 

IT’IS Foundation has Strong Showing in Beijing at URSI GASS 2014

The 31st General Assembly of the International Union of Radio Science (URSI GASS 2014) was held August 16 – 23, 2014 at the Beijing Conference Center in downtown Beijing, China.

 
Other News

17/07/2014

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nk@itis.etzh.ch

 

2014 IEEE Biomedical Electronics EMC Workshop and IT'IS Partners Featured on Taiwanese TV

The Taiwanese television news and information program ‘100% Life’ covered the 2014 IEEE Biomedical Electronics EMC Workshop held on May 23, 2014 in Taipei.

 
PUBLICATIONS

03/07/2014

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nk@itis.ethz.ch

 

Influence of Non Ionizing Radiation of Base Stations on the Activity of Redox Proteins in Bovines

Michael Hässig, Marietta Wullschleger, Hanspeter Naegeli, Jaqueline Kupper, Bernhard Spiess, Niels Kuster, Myles Capstick, and Manuel Murbach, BMC Veterinary Research, Volume 10, Issue 136, online June 19, 2014

 
Other News

18/06/2014

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nk@itis.etzh.ch

 

IEEE Microwave Magazine Conference Report on IEEE MTT-S IMWS-Bio 2013

The current issue of IEEE Microwave Magazine (June 2014) features a report about the International Microwave Workshop Series on RF and Wireless Technologies for Biomedical and Healthcare Applications (IMWSBio 2013), held last year in Singapore during which Niels delivered a keynote presentation entitled “In Silico Effectiveness and Safety Evaluations of Active Implantable Neuro-Stimulating Devices: Still A Dream or Soon Reality”.

 
Other News

05/06/2014

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nk@itis.etzh.ch

 

IT’IS Participates in ICS14 at Technopark, Zurich

This year’s International Interdisciplinary Cerebrovascular Symposium and IntraCranial Stent meeting, organized by the SwissNeuroFoundation, featured several research areas of interest and relevance to IT’IS, including computational flow dynamics (CFD) and the use of simulation for regulatory procedures.

 
Other News

26/05/2014

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nk@itis.etzh.ch

 

IT'IS at IEEE Biomedical Electronics EMC Symposium in Taipei

Niels Kuster gave the keynote lectures at the IEEE Biomedical Electronics EMC Symposium in Taipei, Taiwan on May 23 about the “Future of Evaluating Effectiveness, Safety, and EMC/EMI of Body-Mounted and Implanted Systems.”

 
VIRTUAL POPULATION

23/05/2014

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vip@itis.ethz.ch

 

Release of the First Models of Virtual Population ViP V2.0 and V3.0!

Over the past two years our team has been working overtime to further improve the quality of our Virtual Population V1.0. IT’IS is proud to announce the release of the next generation of computational whole-body human anatomical models: the Virtual Population V2.0 and V3.0.

 

 
Other News

20/05/2014

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nk@itis.etzh.ch

 

 
Other News

29/04/2014

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nk@itis.etzh.ch

 

IT’IS and ZMT Zurich MedTech at MEET THE EXPERT - Implants Conference

Dr. Earl Zastrow of the IT’IS Foundation and Dr. Cabanes and Ms. Minana Maiques of ZMT Zurich MedTech attended a conference entitled MEET THE EXPERT - Implants that took place in Interlaken, Switzerland. The 2-day event (April 28 – 29) convened speakers and exhibitors with the aim to present new developments in area of passive and active medical implants and to trigger collaborations.

 
PUBLICATIONS

12/03/2014

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nk@itis.ethz.ch

 

Human Exposure to Close-Range Resonant Wireless Power Transfer Systems as a Function of Design Parameters

Xi Lin Chen, Aghuinyue Umenei, David Baarman, Nicolas Chavannes, Valerio De Santis, Juan Mosig, and Niels Kuster, IEEE Transactions on Electromagnetic Compatibility, Volume 56, Issue 5, pp. 1027-1034, online March 12, 2014

 
PUBLICATIONS

01/03/2014

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nk@itis.ethz.ch

 

Dosimetric Assessment of Two-Layer Cell Culture Configurations for Fertility Research at 1950 MHz

Yijian Gong, Manuel Murbach, Teruo Onishi, Myles Capstick, Toshio Nojima, and Niels Kuster, IEICE Transactions on Communications, Volume E97-B, Issue 3, pp. 631-637, online March 1, 2014

 
PUBLICATIONS

16/02/2014

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nk@itis.ethz.ch

 

Modeling of EEG Electrode Artifacts and Thermal Ripples in Human Radiofrequency Exposure Studies

Manuel Murbach, Esra Neufeld, Maria Christopoulou, Peter Achermann, and Niels Kuster, Bioelectromagnetics, Volume 35, Issue 4, pp. 273-283, online February 13, 2014

 

 
Other News

31/01/2014

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nk@itis.etzh.ch

 

IT’IS Review Article Makes the Cover of the International Journal of Hyperthermia

An image from the recent review article authored by Adamos Kyriakou, Esra Neufeld, Beat Werner, Margarethus Paulides, Gabor Szekely, and Niels Kuster, entitled “A Review of Numerical and Experimental Compensation Techniques for Skull-Induced Phase Aberrations in Transcranial Focused Ultrasound” (Int. J. Hyperthermia, 2014; 30: 36–46) has been featured on the cover of the journal issue.

 
Other News

22/01/2014

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nk@itis.etzh.ch

 

IT’IS to Provide Dosimetry Expertise in Newly Launched EU-Funded GERoNiMO Project

Myles Capstick represented IT’IS at the GERoNiMO (Generalised EMF Research using Novel Methods) project kickoff meeting, convened at the Centre for Research in Environmental Epidemiology (CREAL), an ISGlobal research center, in Barcelona, Spain, 16 – 17th January 2014.

 
Other News

15/01/2014

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nk@itis.etzh.ch

 

IT'IS/Speag/ZMT Retreat in Bergün on Winning and Failing Strategies and Mindsets

Twenty-two IT'IS, SPEAG, and ZMT co-workers retreated for two days, 13 – 14 January 2014, to the Kurhaus Bergün, a grand old Jugendstil-era hotel in the Albula region of canton Graubünden. Their mission: to learn about the strategies and mindsets that impact workplace productivity and success, as well as winning and failing strategies and mindsets implemented by leaders, empires, and industries.

 
Other News

19/12/2013

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nk@itis.etzh.ch

 

DISCIPULUS - Digital Patient Roadmap is Now Available Online

The latest version of the Digital Patient Roadmap was recently made available online (click here to download) at the website of the EU-funded DISCIPULUS project. Davnah Payne represented the IT’IS Foundation during the production of the patient roadmap, contributing as a writer and/or editor of chapters 2, 3, and 5.

 
PUBLICATIONS

10/12/2013

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nk@itis.ethz.ch

 

A Review of Numerical and Experimental Compensation Techniques for Skull-Induced Phase Aberrations in Transcranial Focused Ultrasound

Adamos Kyriakou, Esra Neufeld, Beat Werner, Margarethus Paulides, Gabor Szekely, and Niels Kuster, International Journal of Hyperthermia, Volume 30, Issue 1, pp. 36-46, February 2014, online December 10, 2013

 

 
PUBLICATIONS

26/11/2013

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nk@itis.ethz.ch

 

Experimental and Numerical Assessment of Low-Frequency Current Distributions from UMTS and GSM Mobile Phones

Marie-Christine Gosselin, Sven Kühn, and Niels Kuster, Physics in Medicine and Biology, Volume 58, Issue 23, pp. 8339–8357, December 2013, online November 11, 2013

 

 
Other News

14/11/2013

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nk@itis.etzh.ch

 

Robotics Research Rocks - 2013 National Future Day

Nine curious young people spent Thursday, November 14 visiting our team at the IT’IS, SPEAG, and ZMT laboratories for the 2013 National Future Day.

 
PUBLICATIONS

30/10/2013

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nk@itis.ethz.ch

 

Xi Lin (2013) Thesis

Chen Xi Lin, “Computational Analysis and Methods for Electromagnetic Exposure Limits, Antenna Optimization and Cell Phone Design”, PhD Thesis, Swiss Federal Insititute of Technology, Thesis No. 5984, Lausanne, 2013

 
PUBLICATIONS

25/10/2013

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nk@itis.ethz.ch

 

Murbach (2013) Thesis

Manuel Murbach, “EMF Risk Assessment: Exposure Assessment and Safety Considerations in MRI and other Environments”, PhD Thesis, Swiss Federal Insititute of Technology, Thesis No. 21514, Zurich, 2013

 
Other News

14/10/2013

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nk@itis.ethz.ch

 

ARIMMORA Project Progress Meeting in Salamanca

October 7-8, 2013: ARIMMORA Project Progress Meeting in Salamanca, Spain

 
Other News

06/09/2013

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nk@itis.ethz.ch

 

New SAR Measurement Standard Published

A new international standard for SAR measurements, IEEE 1528-2013, was published on 6 September, incorporating new procedures to improve testing efficiency while maintaining excellent measurement reproducibility and low uncertainty.

 

 
PUBLICATIONS

14/08/2013

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nk@itis.ethz.ch

 

A Novel Medical Image Data-Based Multi-Physics Simulation Platform for Computational Life Sciences

Esra Neufeld, Dominik Szczerba, Nicolas Chavannes, and Niels Kuster, Interface Focus, Volume 3, Issue 3, April 2013, online February 21, 2013 

 

 
ANNUAL REPORTS

01/08/2013

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nk@itis.ethz.ch

 

IT'IS Annual Report 2012

The Annual Report 2012 features key figures for 2012 and overviews of selected projects:

  • Evaluation of Wireless Network Devices (FP7-ENV Project SEAWIND)
  • Functionalized Head Model for EM-Neuron Interaction Modeling
  • Pushing the Envelope Toward Advanced RF MRI Safety Concepts
  • Reshaping the Future of Bioelectromagnetics on Monte Verità 2012

 
Other News

30/07/2013

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nk@itis.ethz.ch

 

Thank you Q

Prof. Dr. Quirino Balzano of the University of Maryland Department of Electrical and Computer Engineering and a member of the IT’IS Foundation Board completed his one-month sojourn at IT’IS on July 30.

 
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