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PUBLICATIONS

10/05/2004

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nk@itis.ethz.ch

 

A Novel 3-D CPFDTD Scheme for Modeling Grid Non-conformally Aligned Transmitter Structures

Nicolas Chavannes and Niels Kuster, IEEE Transactions on Antennas and Propagation, Volume 52, Issue 5, pp. 1324–1334, May 2004

 

 
PUBLICATIONS

01/05/2004

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nk@itis.ethz.ch

 

High Frequency Electromagnetic Fields (gsm Signals) Affect Gene Expression Levels in Tumor Suppressor p53-deficient Embryonic Stem Cells

Jaroslaw Czyz, Kaomei Guan, Qinghua Zeng, Teodora Nikolova, Armin Meister, Frank Schönborn, Jürgen Schuderer, Niels Kuster and Anna M. Wobus, Bioelectromagnetics, Volume 25, Issue 4, pp. 296–307, May 2004

 

 
PUBLICATIONS

01/05/2004

Contact
nk@itis.ethz.ch

 

Novel High Resolution Temperature Probe for Radiofrequency Dosimetry

Jürgen Schuderer, Thomas Schmid, Gerald Urban, Theodoros Samaras, and Niels Kuster, Physics in Medicine and Biology, Volume 49, Issue 6, pp. N83–N92, March 2004

 

 
Non-Thermal Effects of Power-Line Magnetic Fields (50 Hz) on Gene Expression Levels of Pluripotent Embryonic Stem Cells—The Role of Tumour Suppressor p53
15/01/2004

Non-Thermal Effects of Power-Line Magnetic Fields (50 Hz) on Gene Expression Levels of Pluripotent Embryonic Stem Cells—The Role of Tumour Suppressor p53

Jaroslaw Czyz, Teodora Nikolova, Jürgen Schuderer, Niels Kuster, and Anna M. Wobus, Mutation Research/Genetic Toxicology and Environmental Mutagenesis, Volume 557, Issue 1, pp. 63–74, January 2004


The diffusion of extremely low-frequency (50 Hz) electromagnetic fields (ELF-EMF) in the human environment raises the question of the induction of biological effects of EMF on mammalian cells. We used the model of mouse pluripotent embryonic stem (ES) cells, which have the capacity to develop in vitro into cells of all lineages, to analyse non-thermal effects of ELF-EMF. Wild type (wt) and p53-deficient ES cells were exposed under controlled conditions to ELF-EMF signals simulating power-line (50 Hz) magnetic field (PL-MF) exposure. Different flux densities of 0.1 mT, 1.0 mT or 2.3 mT and intermittency schemes with various ON/OFF cycles were applied for 6 h or 48 h during the first stages of cell differentiation. Transcript levels of regulatory genes, such as egr-1, p21, c-jun, c-myc, hsp70 and bcl-2, were analysed by semi-quantitative RT-PCR immediately after exposure or after a recovery time of 18 h. Intermittent PL-MF exposure to 5 min ON/30 min OFF cycles at a flux density of 2.3 mT for 6 h resulted in a significant up-regulation of c-jun, p21 and egr-1 mRNA levels in p53-deficient, but not in wild-type cells. No significant effects were observed in both cell systems by PL-MF at lower flux densities, longer exposure time or after 18 h recovery time. Our data indicate that 5 min ON/30 min OFF intermittent PL-MF exposure is capable of evoking non-thermal responses in ES cells, dependent on the cellular p53 function. The nature of the biological responses triggered by PL-MF is discussed.

PUBLICATIONS

15/01/2004

Contact
nk@itis.ethz.ch

 

Dosimetric Analysis of the Carousel Setup for the Exposure of Rats at 1.62 GHz

Frank Schönborn, Katja Pokovic, Christian Brösamle, and Niels Kuster, Bioelectromagnetics, Volume 25, Issue 1, pp. 16–26, January 2004