NEWS
PUBLICATIONS

31/10/2016

Contact
nk@itis.ethz.ch

 

From Image-Based Modeling to the Modeling of Imaging with the Virtual Population

Esra Neufeld, Bryn Lloyd, and Niels Kuster, in Simulation and Synthesis in Medical Imaging, Proceedings of the First International Workshop, SASHIMI 2016, Held in Conjunction with MICCAI 2016, Athens, Greece, October 21, 2016, Volume 9968 of the series Lecture Notes in Computer Science, pp. 45–54, online October, 2016

 
PUBLICATIONS

14/10/2016

Contact
nk@itis.ethz.ch

 

Signaling by sulfur-containing molecules. Quantitative aspects.

Willem H. Koppenol and Patricia L. Bounds, Archives of Biochemistry and Biophysics, online September 23, 2016

 
PUBLICATIONS

12/10/2016

Contact
nk@itis.ethz.ch

 

Magnetic Nanoparticle-Induced Hyperthermia with Appropriate Payloads: Paul Ehrlich’s “Magic (Nano)bullet” for Cancer Theranostics?

Nilroy R. Datta, Sunil Krishnan, Daniel E. Speiser, Esra Neufeld, Niels Kuster, Stefan Bodis, and Heinrich Hofmann,
Cancer Treatment Reviews, Volume 50, pp. 217–227, online September 2016

 
Approach to Validate Simulation-Based Distribution Predictions Combining the Gamma-Method and Uncertainty Assessment: Application to Focused Ultrasound
10/10/2016

Approach to Validate Simulation-Based Distribution Predictions Combining the Gamma-Method and Uncertainty Assessment: Application to Focused Ultrasound

Esra Neufeld, Adamos Kyriacou, Wolfgang Kainz, and Niels Kuster, Journal of Verification, Validation and Uncertainty Quantification, Volume 1, Issue 3, 031006, online September 2016

This paper presents a novel approach for simulation validation by combining systematic, National Institute of Standards and Technology-guideline-based uncertainty assessment with the gamma dose distribution comparison method, and applies the approach to simulated and measured complicated pressure distributions in the field of focused ultrasound. Simulations require verification and validation to demonstrate that they correctly implement the underlying model and sufficiently capture the real-world behavior of the system of interest within the context-of-use. Uncertainty assessment is necessary to determine the quality (strength, success, and range) of the validation. The combined approach of systematic uncertainty evaluation and the gamma-method presented herein permits thorough validation with meaningful and reasonable tolerances, whereas point-wise comparison would have resulted in an unacceptably large uncertainty (>10 dB) due to the impact of distortion. The approach presented also provides a scalar agreement metric and a natural means of visualizing areas of disagreement. Verification is achieved by identifying the critical physical and numerical phenomena and ascertaining correct handling by means of analytical and numerical benchmarks. The generality of the verification and validation approach presented makes it applicable to a wide range of computational models, beyond the highlighted acoustic simulations.

The scientific and technical impact of the study can be summarized as: 

  • A novel approach for simulation validation that combines systematic uncertainty assessment with the gamma dose distribution comparison method is described
  • The approach was successfully tested by application to simulated and measured complicated pressure distributions in the field of focused ultrasound
  • The new approach provides an objective validation criterion, reasonably stringent tolerances, and intuitive visualization of the spatial distribution of agreement quality
  • Verification is performed by identification of the fundamental physical and numerical phenomena, with implementation ascertained with analytical and numerical reference solutions
PUBLICATIONS

23/09/2016

Contact
nk@itis.ethz.ch

 

Virtual Population-Based Assessment of the Impact of 3 Tesla Radiofrequency Shimming and Thermoregulation on Safety and B1+ Uniformity

Manuel Murbach, Esra Neufeld, Eugenia Cabot, Earl Zastrow, Juan Córcoles, Wolfgang Kainz, and Niels Kuster, Magnetic Resonance in Medicine, Volume 76, Issue 3, pp. 986–997, September 2016; Early View, September 2015, online September 24, 2015

 
PUBLICATIONS

15/08/2016

Contact
nk@itis.ethz.ch

 

Parallel smoothing pressure correction solver for biomedical flow problems: convergence criteria, preconditioning, scalability

Kathrin Burckhardt, Dominik Szczerba, Esra Neufeld, Krishnamurthy Muralidhar, and Niels Kuster, Progress in Computational Fluid Dynamics, Volume 16, Issue 4, pp. 201–215, online August 10, 2016

 
PUBLICATIONS

07/06/2016

Contact
nk@itis.ethz.ch

 

Investigation of assumptions underlying current safety guidelines on EM-induced nerve stimulation

Esra Neufeld, Ioannis Vogiatzis Oikonomidis, Maria Ida Iacono, Leonardo M. Angelone, Wolfgang Kainz, and Niels Kuster, Physics in Medicine and Biology, Volume 61, Issue 12, pp. 4466–4478, online May 2016

 
PUBLICATIONS

07/06/2016

Contact
nk@itis.ethz.ch

 

Functionalized anatomical models for EM-neuron interaction modeling

Esra Neufeld, Antonino M. Cassara, Hazael Montanaro, and Niels Kuster, Physics in Medicine and Biology, Volume 61, Issue 12, 4390–4401, online May 25, 2016

 
PUBLICATIONS

18/05/2016

Contact
nk@itis.ethz.ch

 

Comparative dosimetry for children and rodents exposed to extremely low-frequency magnetic fields

Yijian Gong, Myles Capstick, Clemens Dasenbrock, Maren Fedrowitz, Cesar Cobaleda, Isidro Sanchez-Garcia, and Niels Kuster, Bioelectromagnetics, Volume 37, Issue 5, pp. 310–322, July 2016, online May 13, 2016