NEWS
PUBLICATIONS

15/01/2017

Contact
nk@itis.ethz.ch

 

Terahertz reflectarrays and nonuniform metasurfaces

Daniel Headland, Tiaoming Niu, Eduardo Carrasco, Derek Abbott, Shruti Nirantar, Sharath Sriram, Madhu Bhaskaran, Christophe Fumeaux, and Withawat Withayachumnankul, IEEE Journal of Selected Topics in Quantum Electronics, online 20 December 2016, DOI: 10.1109/JSTQE.2016.2640452

 
PUBLICATIONS

31/10/2016

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nk@itis.ethz.ch

 

From Image-Based Modeling to the Modeling of Imaging with the Virtual Population

Esra Neufeld, Bryn Lloyd, and Niels Kuster, in Simulation and Synthesis in Medical Imaging, Proceedings of the First International Workshop, SASHIMI 2016, Held in Conjunction with MICCAI 2016, Athens, Greece, October 21, 2016, Volume 9968 of the series Lecture Notes in Computer Science, pp. 45–54, online October, 2016

 
PUBLICATIONS

14/10/2016

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nk@itis.ethz.ch

 

Signaling by sulfur-containing molecules. Quantitative aspects.

Willem H. Koppenol and Patricia L. Bounds, Archives of Biochemistry and Biophysics, online September 23, 2016

 
Magnetic Nanoparticle-Induced Hyperthermia with Appropriate Payloads: Paul Ehrlich’s “Magic (Nano)bullet” for Cancer Theranostics?
12/10/2016

Magnetic Nanoparticle-Induced Hyperthermia with Appropriate Payloads: Paul Ehrlich’s “Magic (Nano)bullet” for Cancer Theranostics?

Nilroy R. Datta, Sunil Krishnan, Daniel E. Speiser, Esra Neufeld, Niels Kuster, Stefan Bodis, and Heinrich Hofmann, Cancer Treatment Reviews, Volume 50, pp. 217–227, online September 2016

Effective multimodal cancer management requires the optimal integration of diagnostic and therapeutic modalities. Radiation therapy, chemotherapy, and immunotherapy – alone or in combination – are integral parts of various cancer treatment protocols. Hyperthermia at 39 – 45°C is a potent radiosensitiser and has been shown to improve therapeutic outcomes in various tumours through its synergy with chemotherapy. Gene silencing approaches with small interfering RNAs and microRNAs are also being explored in clinical trials in oncology. The rapid developments in multifunctional nanoparticles provide ample opportunities to integrate both diagnostic and therapeutic modalities into a single effective cancer “theranostic” vector. Nanoparticles could be extravasated passively into the tumour tissues preferentially over adjacent normal tissues due to their enhanced permeability and retention effects. Tumour targeting might be further augmented by conjugating tumour-specific peptides and antibodies onto the surface of these nanoparticles or by activation through electromagnetic radiations, laser, or ultrasound. Magnetic nanoparticles can induce hyperthermia in the presence of an alternating magnetic field, thereby empowering multifunctional tumour-specific payloads based on radiotheranostics (for both imaging and radiotherapy), chemotherapeutic drug delivery, immunotherapy, and gene-silencing therapy. Such a (nano)bullet could realise the “magic bullet” conceived by Paul Ehrich more than a century ago. This review article discusses the various aspects of this “magic (nano)bullet” and the challenges that need to be addressed to usher in this new paradigm in modern cancer diagnostics and therapeutics.

The scientific and technical impact of the review paper can be summarized as:

  • Magnetic nanoparticles with appropriate payloads can be effective cancer theranostic agents
  • Critical payloads can be designed to offer personalized cancer diagnosis and therapy
  • Magnetic nanoparticles enable integration of thermochemoradio-, immuno-, and gene-silencing-therapies
  • Magnetic nanoparticle hyperthermis treatment planning for thermal dosimetry and optimization of treatment personalization is feasible
  • Image-based, multiphysics-multiscale simulation, and physiology modelling are key for such treatment planning
PUBLICATIONS

10/10/2016

Contact
nk@itis.ethz.ch

 

Approach to Validate Simulation-Based Distribution Predictions Combining the Gamma-Method and Uncertainty Assessment: Application to Focused Ultrasound

Esra Neufeld, Adamos Kyriacou, Wolfgang Kainz, and Niels Kuster, Journal of Verification, Validation and Uncertainty Quantification, Volume 1, Issue 3, 031006, online September 2016

 
PUBLICATIONS

23/09/2016

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nk@itis.ethz.ch

 

Virtual Population-Based Assessment of the Impact of 3 Tesla Radiofrequency Shimming and Thermoregulation on Safety and B1+ Uniformity

Manuel Murbach, Esra Neufeld, Eugenia Cabot, Earl Zastrow, Juan Córcoles, Wolfgang Kainz, and Niels Kuster, Magnetic Resonance in Medicine, Volume 76, Issue 3, pp. 986–997, September 2016; Early View, September 2015, online September 24, 2015

 
PUBLICATIONS

15/08/2016

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nk@itis.ethz.ch

 

Parallel smoothing pressure correction solver for biomedical flow problems: convergence criteria, preconditioning, scalability

Kathrin Burckhardt, Dominik Szczerba, Esra Neufeld, Krishnamurthy Muralidhar, and Niels Kuster, Progress in Computational Fluid Dynamics, Volume 16, Issue 4, pp. 201–215, online August 10, 2016

 
PUBLICATIONS

07/06/2016

Contact
nk@itis.ethz.ch

 

Investigation of assumptions underlying current safety guidelines on EM-induced nerve stimulation

Esra Neufeld, Ioannis Vogiatzis Oikonomidis, Maria Ida Iacono, Leonardo M. Angelone, Wolfgang Kainz, and Niels Kuster, Physics in Medicine and Biology, Volume 61, Issue 12, pp. 4466–4478, online May 2016

 
PUBLICATIONS

07/06/2016

Contact
nk@itis.ethz.ch

 

Functionalized anatomical models for EM-neuron interaction modeling

Esra Neufeld, Antonino M. Cassara, Hazael Montanaro, and Niels Kuster, Physics in Medicine and Biology, Volume 61, Issue 12, 4390–4401, online May 25, 2016