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PUBLICATIONS

13/09/2017

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nk@itis.ethz.ch

 

Novel hyperthermia applicator system allows adaptive treatment planning: Preliminary clinical results in tumour-bearing animals

S. Dressel, M.-C. Gosselin, M. H. Capstick, E. Carrasco, M. S. Weyland, S. Scheidegger, E. Neufeld, N. Kuster, S. Bodis, and C. Rohrer Bley, Veterinary and Comparative Oncology, online 11 September, 2017, doi: 10.1111/vco.12340

 
PUBLICATIONS

20/07/2017

 

On the Use of Conformal Models and Methods in Dosimetry for Non-Uniform Field Exposure

Dragan Poljak, Mario Cvetkovi´c, Oriano Bottauscio, Akimasa Hirata, Ilkka Laakso, Esra Neufeld, Sylvain Reboux, Craig Warren, Antonis Giannopolous, and Fumie Costen, IEEE Transactions on Electromagnetic Compatibility, online 18 July, 2017, doi: 10.1109/TEMC.2017.2723459

 
Effects of body habitus on internal radiation dose calculations using the 5-year-old anthropomorphic male models
17/07/2017

Effects of body habitus on internal radiation dose calculations using the 5-year-old anthropomorphic male models

Tianwu Xie, Niels Kuster, and Habib Zaidi, Physics in Medicine & Biology, Volume 62, Issue 15, pp. 6185–6206, online 13 July 2017, doi: 10.1088/1361-6560/aa75b4

Computational phantoms are commonly used in internal radiation dosimetry to assess the amount and distribution pattern of energy deposited in various parts of the human body from different internal radiation sources. Radiation dose assessments are commonly performed on predetermined reference computational phantoms, although the argument for individualized patient-specific radiation dosimetry exists. The aim of this study is to evaluate the influence of body habitus on internal dosimetry and to quantify the uncertainties in dose estimation correlated with the use of fixed reference models. The 5-year-old IT'IS male phantom was modified to match target anthropometric parameters, including body weight, body height, and sitting/height stature ratio (SSR) determined from reference databases, thus enabling the creation of 125 5-year-old habitus-dependent male phantoms with 10th, 25th, 50th, 75th, and 90th percentile body morphometries. We evaluated the absorbed fractions and the mean absorbed dose to the target region per unit cumulative activity in the source region (S-values) of F-18 in 46 source regions for the 125 anthropomorphic 5-year-old hybrid male phantoms generated by means of the Monte Carlo N-Particle eXtended (MCNPX) general purpose Monte Carlo transport code and calculated the absorbed dose and effective dose of five 18F-labelled radiotracers for children of various habitus. For most organs, the S-value of F-18 presents stronger statistical correlations with body weight, standing height, and sitting height than with BMI and SSR. The self-absorbed fraction and self-absorbed S-values of F-18 and the absorbed dose and effective dose of 18F-labelled radiotracers present with the strongest statistical correlations with body weight. For 18F-amino acids, 18F-brain receptor substances, 18F-FDG, 18F-L-DOPA, and 18F-FBPA, the mean absolute effective dose differences between phantoms of different habitus and fixed reference models are 11.4%, 11.3, 10.8, 13.3, and 11.4%, respectively. Total body weight, standing height, and sitting height have considerable effects on human internal dosimetry. Radiation dose calculations for individual subjects based on the most closely matched habitus-dependent computational phantom should be considered as an alternative to improve the accuracy of the estimates.

The scientific and technical impact of the study can be summarized as:

  • The detailed analysis of habitus-dependent dosimetric results for the 5-year-old child supports arguments for the application of individual patient dose assessment.
  • Total body weight, standing height, sitting height, BMI, and SSR influence the calculation of absorbed fractions and S-values of F-18 and absorbed dose and effective dose of 18F-labelled radiotracers.
  • For most organs, the absorbed fractions of F-18 increase as a function of total body weight and BMI, while the self-absorbed S-values of F-18 as well as absorbed and effective doses of 18F-labelled radiotracers decrease with body weight and BMI.
  • Dose comparisons between habitus-dependent phantoms and predefined phantoms corresponding to ICRP reference data reveal that the use of the most closely matched habitus-dependent phantom is superior to the use of a predefined reference phantom for estimation of internal dose in an individual patient. 
PUBLICATIONS

01/06/2017

Contact
nk@itis.ethz.ch

 

Noninvasive Deep Brain Stimulation via Temporally Interfering Electric Fields

Nir Grossman, David Bono, Nina Dedic, Suhasa B. Kodandaramaiah, Andrii Rudenko, Ho-Jun Suk, Antonino M. Cassara, Esra Neufeld, Niels Kuster, Li-Huei Tsai, Alvaro Pascual-Leone, and Edward S. Boyden, Cell, Volume 169, Issue 6, pp. 1029–1041, online 1 June 2017, doi: 10.1016/j.cell.2017.05.024

 
PUBLICATIONS

05/04/2017

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nk@itis.ethz.ch

 

Life-Time Dosimetric Assessment for Mice and Rats Exposed in Reverberation Chambers for the Two-Year NTP Cancer Bioassay Study on Cell Phone Radiation

Yijian Gong, Myles H. Capstick, Sven Kuehn, Perry F. Wilson, John M. Ladbury, Galen Koepke, David L. McCormick, Ronald L. Melnick, and Niels Kuster, IEEE Transactions on Electromagnetic Compatibility, online 17 March 2017, doi: 10.1109/TEMC.2017.2665039

 
PUBLICATIONS

04/04/2017

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nk@itis.ethz.ch

 

A Radio Frequency Radiation Exposure System for Rodents Based on Reverberation Chambers

Myles H. Capstick, Sven Kuehn, Veronica Berdinas-Torres, Yijian Gong, Perry F. Wilson, John M. Ladbury, Galen Koepke, David L. McCormick, James Gauger, Ronald L. Melnick, and Niels Kuster, IEEE Transactions on Electromagnetic Compatibility, Volume 59, Issue 4, pp. 1041–1052. August 2017, online 17 March 2017, doi: 10.1109/TEMC.2017.2649885

 
PUBLICATIONS

28/03/2017

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nk@itis.ethz.ch

 

Computational hybrid anthropometric paediatric phantom library for internal radiation dosimetry

Tianwu Xie, Niels Kuster, and Habib Zaidi, Physics in Medicine and Biology, Volume 62, Issue 8, pp. 3263–3283. 21 April, 2017, online 28 March 2017, doi: 10.1088/1361-6560/aa63d0

 
PUBLICATIONS

13/03/2017

Contact
nk@itis.ethz.ch

 

ELF‑MF exposure affects the robustness of epigenetic programming during granulopoiesis

Melissa Manser, Mohamad R. Abdul Sater, Christoph D. Schmid, Faiza Noreen, Manuel Murbach, Niels Kuster, David Schuermann, and Primo Schär, Scientific Reports 2017, Volume 7, Article number: 43345, online: 07 March 2017, DOI: 10.1038/srep43345.