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PUBLICATIONS

13/09/2017

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nk@itis.ethz.ch

 

Novel hyperthermia applicator system allows adaptive treatment planning: Preliminary clinical results in tumour-bearing animals

S. Dressel, M.-C. Gosselin, M. H. Capstick, E. Carrasco, M. S. Weyland, S. Scheidegger, E. Neufeld, N. Kuster, S. Bodis, and C. Rohrer Bley, Veterinary and Comparative Oncology, online 11 September, 2017, doi: 10.1111/vco.12340

 
PUBLICATIONS

20/07/2017

 

On the Use of Conformal Models and Methods in Dosimetry for Non-Uniform Field Exposure

Dragan Poljak, Mario Cvetković, Oriano Bottauscio, Akimasa Hirata, Ilkka Laakso, Esra Neufeld, Sylvain Reboux, Craig Warren, Antonis Giannopolous, and Fumie Costen, IEEE Transactions on Electromagnetic Compatibility, online 18 July, 2017, doi: 10.1109/TEMC.2017.2723459

 
PUBLICATIONS

17/07/2017

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nk@itis.ethz.ch

 

Effects of body habitus on internal radiation dose calculations using the 5-year-old anthropomorphic male models

Tianwu Xie, Niels Kuster, and Habib Zaidi, Physics in Medicine & Biology, Volume 62, Issue 15, pp. 6185–6206, online 13 July 2017, doi: 10.1088/1361-6560/aa75b4

 
Noninvasive Deep Brain Stimulation via Temporally Interfering Electric Fields
01/06/2017

Noninvasive Deep Brain Stimulation via Temporally Interfering Electric Fields

Nir Grossman, David Bono, Nina Dedic, Suhasa B. Kodandaramaiah, Andrii Rudenko, Ho-Jun Suk, Antonino M. Cassara, Esra Neufeld, Niels Kuster, Li-Huei Tsai, Alvaro Pascual-Leone, and Edward S. Boyden, CellVolume 169, Issue 6, pp. 1029–1041, online 1 June 2017, doi: 10.1016/j.cell.2017.05.024

The paper reports a noninvasive strategy for electrically stimulating neurons at depth. By delivering to the brain multiple electric fields at frequencies too high to recruit neural firing, but which differ by a frequency within the dynamic range of neural firing, it is possible to electrically stimulate neurons throughout a region where interference between the multiple fields results in a prominent electric field envelope modulated at the difference frequency. This temporal interference (TI) concept was validated via modeling and physics experiments, and it was verified that neurons in the living mouse brain could follow the electric field envelope. The utility of TI stimulation is demonstrated by stimulating neurons in the hippocampus of living mice without recruiting neurons of the overlying cortex. Finally, it is shown that by altering the currents delivered to a set of immobile electrodes, different motor patterns can be steerably evoked in living mice.

The scientific and technical impact of the study can be summarized as:

  • A new, noninvasive technique to stimulate deep brain structures has been developed and tested by using computational modeling and phantom measurements, as well as electrophysiological measurements in vivo;
  • TI stimulation sends interfering, low-frequency modulated, high frequency signals from multiple pairs of electrodes placed on the scalp through the brain, avoiding stimulation of other areas;
  • The results make TI stimulation a promising alternative to surgical electrical stimulation interventions such as deep brain stimulation (DBS) for e.g., Parkinson's disease patients.
PUBLICATIONS

05/04/2017

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nk@itis.ethz.ch

 

Life-Time Dosimetric Assessment for Mice and Rats Exposed in Reverberation Chambers for the Two-Year NTP Cancer Bioassay Study on Cell Phone Radiation

Yijian Gong, Myles H. Capstick, Sven Kuehn, Perry F. Wilson, John M. Ladbury, Galen Koepke, David L. McCormick, Ronald L. Melnick, and Niels Kuster, IEEE Transactions on Electromagnetic Compatibility, online 17 March 2017, doi: 10.1109/TEMC.2017.2665039

 
PUBLICATIONS

04/04/2017

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nk@itis.ethz.ch

 

A Radio Frequency Radiation Exposure System for Rodents Based on Reverberation Chambers

Myles H. Capstick, Sven Kuehn, Veronica Berdinas-Torres, Yijian Gong, Perry F. Wilson, John M. Ladbury, Galen Koepke, David L. McCormick, James Gauger, Ronald L. Melnick, and Niels Kuster, IEEE Transactions on Electromagnetic Compatibility, Volume 59, Issue 4, pp. 1041–1052. August 2017, online 17 March 2017, doi: 10.1109/TEMC.2017.2649885

 
PUBLICATIONS

28/03/2017

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nk@itis.ethz.ch

 

Computational hybrid anthropometric paediatric phantom library for internal radiation dosimetry

Tianwu Xie, Niels Kuster, and Habib Zaidi, Physics in Medicine and Biology, Volume 62, Issue 8, pp. 3263–3283. 21 April, 2017, online 28 March 2017, doi: 10.1088/1361-6560/aa63d0

 
PUBLICATIONS

13/03/2017

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nk@itis.ethz.ch

 

ELF‑MF exposure affects the robustness of epigenetic programming during granulopoiesis

Melissa Manser, Mohamad R. Abdul Sater, Christoph D. Schmid, Faiza Noreen, Manuel Murbach, Niels Kuster, David Schuermann, and Primo Schär, Scientific Reports 2017, Volume 7, Article number: 43345, online: 07 March 2017, DOI: 10.1038/srep43345. 

 
PUBLICATIONS

03/02/2017

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nk@itis.ethz.ch

 

Evaluation of the potential of mobile phone specific electromagnetic fields (UMTS) to produce micronuclei in human glioblastoma cell lines

Halh Al-Serori, Michael Kundi, Franziska Ferk, Miroslav Mišík, Armen Nersesyan, Manuel Murbach, Tamara T. Lah, and Siegfried Knasmüller, Toxicology In Vitro, Volume 40, pp. 264–271, April 2017, online 24 January 2017, DOI: 10.1016/j.tiv.2017.01.012.