NEWS
PUBLICATIONS

05/04/2017

Contact
nk@itis.ethz.ch

 

Life-Time Dosimetric Assessment for Mice and Rats Exposed in Reverberation Chambers for the Two-Year NTP Cancer Bioassay Study on Cell Phone Radiation

Yijian Gong, Myles H. Capstick, Sven Kuehn, Perry F. Wilson, John M. Ladbury, Galen Koepke, David L. McCormick, Ronald L. Melnick, and Niels Kuster, IEEE Transactions on Electromagnetic Compatibility, online 17 March 2017, doi: 10.1109/TEMC.2017.2665039

 
PUBLICATIONS

04/04/2017

Contact
nk@itis.ethz.ch

 

A Radio Frequency Radiation Exposure System for Rodents Based on Reverberation Chambers

Myles H. Capstick, Sven Kuehn, Veronica Berdinas-Torres, Yijian Gong, Perry F. Wilson, John M. Ladbury, Galen Koepke, David L. McCormick, James Gauger, Ronald L. Melnick, and Niels Kuster, IEEE Transactions on Electromagnetic Compatibility, Volume 59, Issue 4, pp. 1041–1052. August 2017, online 17 March 2017, doi: 10.1109/TEMC.2017.2649885

 
PUBLICATIONS

28/03/2017

Contact
nk@itis.ethz.ch

 

Computational hybrid anthropometric paediatric phantom library for internal radiation dosimetry

Tianwu Xie, Niels Kuster, and Habib Zaidi, Physics in Medicine and Biology, Volume 62, Issue 8, pp. 3263–3283. 21 April, 2017, online 28 March 2017, doi: 10.1088/1361-6560/aa63d0

 
ELF‑MF exposure affects the robustness of epigenetic programming during granulopoiesis
13/03/2017

ELF‑MF exposure affects the robustness of epigenetic programming during granulopoiesis

Melissa Manser, Mohamad R. Abdul Sater, Christoph D. Schmid, Faiza Noreen, Manuel Murbach, Niels Kuster, David Schuermann, and Primo Schär, Scientific Reports 2017, Volume 7, Article number: 43345, online: 07 March 2017, DOI: 10.1038/srep43345.

Extremely-low-frequency magnetic fields (ELF-MF) have been classified as “possibly carcinogenic” to humans on the grounds of an epidemiological association of ELF-MF exposure with an increased risk of childhood leukemia. Yet, underlying mechanisms have remained obscure. Genome instability seems an unlikely reason, as the energy transmitted by ELF-MF is too low to damage DNA and induce cancer-promoting mutations. ELF-MF, however, may perturb the epigenetic code of genomes, which is well-known to be sensitive to environmental conditions and generally disrupted in cancers, including leukemia. We examined the potential of ELF-MF to influence key epigenetic modifications in leukemic Jurkat cells and in human CD34+ hematopoietic stem cells undergoing in vitro differentiation into the neutrophilic lineage. During granulopoiesis, sensitive genome-wide profiling of multiple replicate experiments did not reveal any statistically significant, ELF-MF-dependent alterations in the patterns of active (H3K4me2) and repressive (H3K27me3) histone markers or in DNA methylation. However, ELF-MF exposure showed consistent effects on the reproducibility of these histone and DNA modification profiles, which appear to be of a stochastic nature but show preferences for the genomic context. The data indicate that ELF-MF exposure stabilizes active chromatin, particularly during the transition from a repressive to an active state during cell differentiation.

The scientific and technical impact of the study can be summarized as:

  • The double-blinded exposure protocols of the sXcELF system were used for the first genome-wide profiling of the epigenetic genome modifications in EMF-MF-exposed human leukemic and differentiating hematopoietic cells
  • No consistent effects of ELF-MF exposure on the patterning of key DNA and histone modifications (H3K4me2, H3K27me3, DNA cytosine methylation) in leukemic and differentiating hematopoietic cells were observed
  • Genomic context-dependent differences in the reproducibility of genomic modification patterns suggest an influence of ELF-MF exposure on epigenetic plasticity
PUBLICATIONS

03/02/2017

Contact
nk@itis.ethz.ch

 

Evaluation of the potential of mobile phone specific electromagnetic fields (UMTS) to produce micronuclei in human glioblastoma cell lines

Halh Al-Serori, Michael Kundi, Franziska Ferk, Miroslav Mišík, Armen Nersesyan, Manuel Murbach, Tamara T. Lah, and Siegfried Knasmüller, Toxicology In Vitro, Volume 40, pp. 264–271, April 2017, online 24 January 2017, DOI: 10.1016/j.tiv.2017.01.012.

 
PUBLICATIONS

02/02/2017

Contact
nk@itis.ethz.ch

 

Effects of personalised exposure on self-rated electromagnetic hypersensitivity and sensibility – A double-blind randomised controlled trial

 

Imke van Moorselaar, Pauline Slottje, Pia Heller, Rob van Strien, Hans Kromhout, Manuel Murbach, Niels Kuster, Roel Vermeulen, and Anke Huss, Environment International, Volume 99, pp. 255–262, February 2017, online 09 December 2016, doi: 10.1016/j.envint.2016.11.031.

 
CONTACT INFORMATION
 
+41 44 245 96 96