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PUBLICATIONS

18/10/2017

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nk@itis.ethz.ch

 

Activation of Signaling Cascades by Weak Extremely Low Frequency Electromagnetic Fields

Einat Kapri-Pardes, Tamar Hanoch, Galia Maik-Rachline, Manuel Murbach, Patricia L. Bounds, Niels Kuster, and Rony Seger Cellular Physiology and Biochemistry, Volume 43, pp. 1533–1546, online October 16, 2017, doi: 10.1159/000481977

 
Novel hyperthermia applicator system allows adaptive treatment planning: Preliminary clinical results in tumour-bearing animals
13/09/2017

Novel hyperthermia applicator system allows adaptive treatment planning: Preliminary clinical results in tumour-bearing animals

S. Dressel, M.-C. Gosselin, M. H. Capstick, E. Carrasco, M. S. Weyland, S. Scheidegger, E. Neufeld, N. Kuster, S. Bodis, and C. Rohrer Bley, Veterinary and Comparative Oncology, online 11 September, 2017, doi: 10.1111/vco.12340

Hyperthermia (HT) as an adjuvant to radiation therapy (RT) is a multimodality method used to enhance the therapeutic efficacy of the treatment of various tumors. High demands are placed on the hardware and treatment-planning software to guarantee that HT treatments are adequately planned and applied. The aim of this prospective study was to determine the effectiveness and safety of the novel HT system in tumor-bearing dogs and cats in terms of local response and toxicity as well as to compare the predicted response with the data actually achieved during heating. A novel applicator with a flexible number of elements and integrated closed-loop temperature-feedback control system, as well as a tool for patient-specific treatment planning, was used in a combined thermoradiotherapy protocol. There was good agreement between clinical outcomes and predicted outcomes based on planning in 7 of 8 cases. Effective HT treatments were planned and verified with the novel system and provided improved quality of life in all but 1 patient. This individualized treatment planning and controlled heat exposure allows adaptive, flexible, and safe HT treatment of palliatively treated animal patients. As the goal of the study was to test the applicability of the HT hardware and software – tumor response was not considered an endpoint (also due to the limited number of heterogeneous cases) – the findings provide proof-of-principle that effective, homogenous heating can be planned and verified. Future work should focus on image-based systems that allow treatment plans to be replanned and adapted shortly before each session, to take therapy-induced anatomical changes and current physiological conditions into consideration.

The scientific and technical impact of the study can be summarized as:

  • A novel HT system – with a patient specific treatment-planning tool and a closed-loop feedback control system to ensure that the applied treatment corresponds to predictions and that provides individually adaptive, flexible, and safe HT treatments – has been developed
  • There was good agreement between clinical outcomes and predictions from planning in 7 of 8 cases
  • All but 1 animal experienced improved quality of life in a palliative-intent treatment setting
  • The study provides proof-of-principle that planned and verified effective, homogenous heating can be used to enhance efficacy of treatment of different tumors

PUBLICATIONS

20/07/2017

 

On the Use of Conformal Models and Methods in Dosimetry for Non-Uniform Field Exposure

Dragan Poljak, Mario Cvetković, Oriano Bottauscio, Akimasa Hirata, Ilkka Laakso, Esra Neufeld, Sylvain Reboux, Craig Warren, Antonis Giannopolous, and Fumie Costen, IEEE Transactions on Electromagnetic Compatibility, online 18 July, 2017, doi: 10.1109/TEMC.2017.2723459

 
PUBLICATIONS

17/07/2017

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nk@itis.ethz.ch

 

Effects of body habitus on internal radiation dose calculations using the 5-year-old anthropomorphic male models

Tianwu Xie, Niels Kuster, and Habib Zaidi, Physics in Medicine & Biology, Volume 62, Issue 15, pp. 6185–6206, online 13 July 2017, doi: 10.1088/1361-6560/aa75b4

 
PUBLICATIONS

01/06/2017

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nk@itis.ethz.ch

 

Noninvasive Deep Brain Stimulation via Temporally Interfering Electric Fields

Nir Grossman, David Bono, Nina Dedic, Suhasa B. Kodandaramaiah, Andrii Rudenko, Ho-Jun Suk, Antonino M. Cassara, Esra Neufeld, Niels Kuster, Li-Huei Tsai, Alvaro Pascual-Leone, and Edward S. Boyden, Cell, Volume 169, Issue 6, pp. 1029–1041, online 1 June 2017, doi: 10.1016/j.cell.2017.05.024

 
PUBLICATIONS

05/04/2017

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nk@itis.ethz.ch

 

Life-Time Dosimetric Assessment for Mice and Rats Exposed in Reverberation Chambers for the Two-Year NTP Cancer Bioassay Study on Cell Phone Radiation

Yijian Gong, Myles H. Capstick, Sven Kuehn, Perry F. Wilson, John M. Ladbury, Galen Koepke, David L. McCormick, Ronald L. Melnick, and Niels Kuster, IEEE Transactions on Electromagnetic Compatibility, online 17 March 2017, doi: 10.1109/TEMC.2017.2665039

 
PUBLICATIONS

04/04/2017

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nk@itis.ethz.ch

 

A Radio Frequency Radiation Exposure System for Rodents Based on Reverberation Chambers

Myles H. Capstick, Sven Kuehn, Veronica Berdinas-Torres, Yijian Gong, Perry F. Wilson, John M. Ladbury, Galen Koepke, David L. McCormick, James Gauger, Ronald L. Melnick, and Niels Kuster, IEEE Transactions on Electromagnetic Compatibility, Volume 59, Issue 4, pp. 1041–1052. August 2017, online 17 March 2017, doi: 10.1109/TEMC.2017.2649885