Release of Tissue Database V4.0

IT’IS Tissue Database V4.0:  Now including tissue elemental composition values for x-ray and gamma radiation studies.


Major ViP Extension: Morphing of Virtual Population Models Broadens BMI Population Coverage

Major ViP Extension: Morphing of Virtual Population Models Broadens BMI Population Coverage

For nearly a decade, regulators and industry have called for additional types of computational models that are urgently needed to broaden population coverage with respect to the body mass index (BMI). Today, we are proud to announce a major breakthrough: a series of validated morphed models that extend our well-known Virtual Population (ViP) library and provide the long-awaited solution for better population coverage.

The new models “mViP” became possible thanks to our recent important achievements to extend non-linear large deformation constitutive equations with a tissue growth term, as well as a robust approach to adaptive unstructured mesh generation that allow to combine morphing with interactive posture editing running on a desktop computer. In the new morphed models, the subcutaneous adipose tissue (SAT) is morphed to simulate how an individual would gain (or lose) weight. The SAT volume expansion, analogous to thermal expansion, deforms surrounding tissue elastically while being constrained by rigid bones.

 1801 morphed ViP web

Three different morphed versions of Ella (22, 26, 30 kg/m²) and Fats (29, 33, 40 kg/m²) have been released at this point, closing major gaps in terms of BMI distribution across our Virtual Population. In addition, a modified model of Ella (Ella Breast Coil) that has been created for specific applications, such as breast coil design or safety assessments, is provided.

Additional morphed models that cover higher BMI values or that take other tissues (e.g., muscle tissue) into consideration will become available soon. Based on the new technology, we are able to provide customized models for specific applications on demand (

An overview of the new models can be found here. For more information, contact us at






IT’IS Receives 5-Year NIH Award to Build an Integrated Simulation Platform for the Neuroscience World

IT’IS is pleased to announce the award of the project o2S2PARC – Open Online Simulations for Stimulating Peripheral Activity to Relieve Conditions. The project is funded by NIH through the Common Fund’s SPARC program to establish a Modeling and Simulation (SIM-) Core within the SPARC Data and Resource Center.





Fats Domino, Namesake of ViP “Fats” Model, Dead at Age 89

Fats Domino, for whom the ViP obese male model “Fats” is named, died of natural causes at his home in Louisiana, USA on 24 October, 2017. The R&B legend was 89 years old.




Release of the First Verified and Validated MRIxViP V1.0 Libraries and IMAnalytics Module V1.0 for Instant, Comprehensive, and Traceable Evaluation of Implantable Medical Devices

MRIxVIP V1.0 and IMAnalytics V1.0: The first comprehensive solutions for fast, verified, validated, and traceable evaluations of implant safety during magnetic resonance imaging (MRI).




Successful NEUROMAN Project Start and Kickoff Meeting

Partners form Switzerland and Korea join forces to create first ever computational phantom with detailed neuronal networks.





Release of New Posable Virtual Population Models V3.1!

IT’IS proudly announces the release of the full range of ViP models, now upgraded for use with the new Poser method available in the multiphysics computational life sciences platform Sim4Life 2.2!