NEWS
01/06/2017
PUBLICATIONS

Noninvasive Deep Brain Stimulation via Temporally Interfering Electric Fields

Nir Grossman, David Bono, Nina Dedic, Suhasa B. Kodandaramaiah, Andrii Rudenko, Ho-Jun Suk, Antonino M. Cassara, Esra Neufeld, Niels Kuster, Li-Huei Tsai, Alvaro Pascual-Leone, and Edward S. Boyden, CellVolume 169, Issue 6, pp. 1029–1041, online 1 June 2017, doi: 10.1016/j.cell.2017.05.024

The paper reports a noninvasive strategy for electrically stimulating neurons at depth. By delivering to the brain multiple electric fields at frequencies too high to recruit neural firing, but which differ by a frequency within the dynamic range of neural firing, it is possible to electrically stimulate neurons throughout a region where interference between the multiple fields results in a prominent electric field envelope modulated at the difference frequency. This temporal interference (TI) concept was validated via modeling and physics experiments, and it was verified that neurons in the living mouse brain could follow the electric field envelope. The utility of TI stimulation is demonstrated by stimulating neurons in the hippocampus of living mice without recruiting neurons of the overlying cortex. Finally, it is shown that by altering the currents delivered to a set of immobile electrodes, different motor patterns can be steerably evoked in living mice.

The scientific and technical impact of the study can be summarized as:

  • A new, noninvasive technique to stimulate deep brain structures has been developed and tested by using computational modeling and phantom measurements, as well as electrophysiological measurements in vivo;
  • TI stimulation sends interfering, low-frequency modulated, high frequency signals from multiple pairs of electrodes placed on the scalp through the brain, avoiding stimulation of other areas;
  • The results make TI stimulation a promising alternative to surgical electrical stimulation interventions such as deep brain stimulation (DBS) for e.g., Parkinson's disease patients.
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PUBLICATIONS

01/07/1993

Contact
nk@itis.ethz.ch

 

Multiple Multipole Method for Simulating EM Problems Involving Biological Studies

Niels Kuster, IEEE Transactions on Biomedical Engineering, Volume 40, Issue 7, pp. 611–620, July 1993

 

 
PUBLICATIONS

01/06/1992

Contact
nk@itis.ethz.ch

 

Multiple Multipole Method Applied to an Exposure Safety Study

Niels Kuster, in ACES Special Issue on Bioelectromagnetic Computations, A.H.J. Fleming and K.H.Joyner, Eds., Applied Computational Electromagnetics Society (ACES) Journal, Volume 7, Issue 2, pp. 43–60, 1992

 

 
PUBLICATIONS

04/04/1992

Contact
nk@itis.ethz.ch

 

Kuster (1992) PhD Thesis

Niels Kuster, “Dosimetric Assessment of EM Sources Near Biological Bodies by Computer Simulations,” PhD Thesis, Swiss Federal Insititute of Technology, Thesis No. 9697, Zurich, 1992

 

 
PUBLICATIONS

04/04/1992

Contact
nk@itis.ethz.ch

 

Bomholt (1992) PhD Thesis

Fin Bomholt, “Die Kopplung elektromagnetischer Wellen durch Öffnungen: Berechnung mit der MMP-Methode,” PhD Thesis, Swiss Federal Insititute of Technology, Thesis No. 9704, Zurich, 1992

 

 
PUBLICATIONS

01/02/1992

Contact
nk@itis.ethz.ch

 

Energy Absorption Mechanism by Biological Bodies in the Near Field of Dipole Antennas Above 300 Mhz

Niels Kuster and Quirino Balzano, IEEE Transactions on Vehicular Technology, Volume 41, Issue 1, pp. 17–23, February 1992

 

 
PUBLICATIONS

01/07/1991

Contact
nk@itis.ethz.ch

 

Computations of Electromagnetic Fields by the Multiple Multipole Method (Generalized Multipole Technique)

Hafner, C. and Niels Kuster, Radio Science, Volume 26, Issue 1, pp. 291–297, 1991

 

 
PUBLICATIONS

01/10/1990

Contact
nk@itis.ethz.ch

 

6 Types of Canonical Problems Based on One Geometrical Model

Niels Kuster, in The ACES Collection of Canonical Problems, Set 1, Harold A. Sabbagh, Ed., Applied Computational Electromagnetics Society (ACES) Journal, Volume 5, Issue 3, pp. 60–81, 1990

 

 
PUBLICATIONS

01/10/1990

Contact
nk@itis.ethz.ch

 

5:1 Dipole Benchmark Case

Art C. Ludwig, Niels Kuster, A. Glisson, and A. Tha, in The ACES Collection of Canonical Problems, Set 1, Harold A. Sabbagh, Ed., Applied Computational Electromagnetics Society (ACES) Journal, Volume 5, Issue 3, pp. 34–59, 1990

 

 
PUBLICATIONS

15/07/1989

Contact
nk@itis.ethz.ch

 

MMP Method Simulation of Antennae with Scattering Objects in the Closer Nearfield

Niels Kuster and R. Ballisti, IEEE Transactions on Magnetics , Volume 25, Issue 4, pp.2881–2883, July 1989

 

 
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