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PUBLICATIONS

14/10/2016

Contact
nk@itis.ethz.ch

 

Signaling by sulfur-containing molecules. Quantitative aspects.

Willem H. Koppenol and Patricia L. Bounds, Archives of Biochemistry and Biophysics, online September 23, 2016

 
PUBLICATIONS

12/10/2016

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nk@itis.ethz.ch

 

Magnetic Nanoparticle-Induced Hyperthermia with Appropriate Payloads: Paul Ehrlich’s “Magic (Nano)bullet” for Cancer Theranostics?

Nilroy R. Datta, Sunil Krishnan, Daniel E. Speiser, Esra Neufeld, Niels Kuster, Stefan Bodis, and Heinrich Hofmann,
Cancer Treatment Reviews, Volume 50, pp. 217–227, online September 2016

 
PUBLICATIONS

10/10/2016

Contact
nk@itis.ethz.ch

 

Approach to Validate Simulation-Based Distribution Predictions Combining the Gamma-Method and Uncertainty Assessment: Application to Focused Ultrasound

Esra Neufeld, Adamos Kyriacou, Wolfgang Kainz, and Niels Kuster, Journal of Verification, Validation and Uncertainty Quantification, Volume 1, Issue 3, 031006, online September 2016

 
Virtual Population-Based Assessment of the Impact of 3 Tesla Radiofrequency Shimming and Thermoregulation on Safety and B1+ Uniformity
23/09/2016

Virtual Population-Based Assessment of the Impact of 3 Tesla Radiofrequency Shimming and Thermoregulation on Safety and B1+ Uniformity

Manuel Murbach, Esra Neufeld, Eugenia Cabot, Earl Zastrow, Juan Córcoles, Wolfgang Kainz, and Niels Kuster, Magnetic Resonance in Medicine, Volume 76, Issue 3, pp. 986–997, September 2016; Early View, September 2015, online September 24, 2015

Magnetic resonance imaging (MRI) has become a routine clinical diagnostic method. Due to the shorter wavelength at 3T, most MRI scanners implement two-port RF shimming to improve image quality. This may significantly alter the RF absorption pattern in patients. This study investigates the effect of RF shimming on local RF power deposition for a wide range of anatomical models, and subsequently estimates the induced temperature increase as a function of the thermoregulatory state of the patient. The newly proposed model for impaired thermoregulation allows conservative estimations for patient groups with limited physiological responses to heating. Worst-case induced peak temperature reach 42.5°C and 45.6°C in patients with normal and impaired thermoregulation, respectively. RF shimming can significantly increase image quality, and can be considered safe for a broad patient population with normal thermoregulation. Patients with impaired thermoregulation should not be scanned outside of the normal operating mode.

The scientific and technical impact of the study can be summarized as:

  • Broad evaluation of the implications of RF shimming on image quality and RF exposure at 3T
  • Newly proposed model for impaired thermoregulation for conservative temperature estimations
  • Identification of worst-case exposure scenarios
  • Comparison of SAR/temperature correlations to theoretically derived models
PUBLICATIONS

15/08/2016

Contact
nk@itis.ethz.ch

 

Parallel smoothing pressure correction solver for biomedical flow problems: convergence criteria, preconditioning, scalability

Kathrin Burckhardt, Dominik Szczerba, Esra Neufeld, Krishnamurthy Muralidhar, and Niels Kuster, Progress in Computational Fluid Dynamics, Volume 16, Issue 4, pp. 201–215, online August 10, 2016

 
PUBLICATIONS

07/06/2016

Contact
nk@itis.ethz.ch

 

Investigation of assumptions underlying current safety guidelines on EM-induced nerve stimulation

Esra Neufeld, Ioannis Vogiatzis Oikonomidis, Maria Ida Iacono, Leonardo M. Angelone, Wolfgang Kainz, and Niels Kuster, Physics in Medicine and Biology, Volume 61, Issue 12, pp. 4466–4478, online May 2016

 
PUBLICATIONS

07/06/2016

Contact
nk@itis.ethz.ch

 

Functionalized anatomical models for EM-neuron interaction modeling

Esra Neufeld, Antonino M. Cassara, Hazael Montanaro, and Niels Kuster, Physics in Medicine and Biology, Volume 61, Issue 12, 4390–4401, online May 25, 2016

 
PUBLICATIONS

18/05/2016

Contact
nk@itis.ethz.ch

 

Comparative dosimetry for children and rodents exposed to extremely low-frequency magnetic fields

Yijian Gong, Myles Capstick, Clemens Dasenbrock, Maren Fedrowitz, Cesar Cobaleda, Isidro Sanchez-Garcia, and Niels Kuster, Bioelectromagnetics, Volume 37, Issue 5, pp. 310–322, July 2016, online May 13, 2016

 
PUBLICATIONS

17/05/2016

Contact
nk@itis.ethz.ch

 

Pregnant women models analyzed for RF exposure and temperature increase in 3T RF shimmed birdcages

Manuel Murbach, Esra Neufeld, Theodoros Samaras, Juan Córcoles, Fraser J. Robb, Wolfgang Kainz, and Niels Kuster, Magnetic Resonance in Medicine, Early View, May 2016, online May 17, 2016